Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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description Rank Gene Network Comparison Type Value Type green network_comparison Filtered red Interaction Map
Results: HTML CSV LaTeX Showing element 1 to 50 of 9634 in total
Network Comparison Type  : Divided
Value Type  : Ranked
description
Rank
green
network_comparison
Filtered
red
Interaction Map
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 18 245.247 1.32082 1 185.678 High confidence
242 13895.8 1.09822 0 15260.6
629 13590.3 1.02915 13205.3 Low confidence
4130 201.5 1.01062 1 199.383
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943] 1038 181.041 1.03148 186.741 High confidence
1328 194.038 1.02218 198.342 Low confidence
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120] 1032 180.943 1.03162 186.664 High confidence
1322 194.014 1.0222 198.322 Low confidence
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5] 588 185.859 1.03039 191.507
1048 182.308 1.031 187.96 High confidence
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7] 637 186.751 1.029 192.166 Low confidence
1043 182.137 1.03128 187.834 High confidence
1-aminocyclopropane-1-carboxylate synthase. [refseq;acc:nm_032592] 3423 196.707 1.01523 199.702 Low confidence
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147] 3126 0.00001 1 0.00001 High confidence
3585 199.628 1.01447 202.517 Low confidence
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984] 1963 213.703 1.00978 211.633 High confidence
2659 196.574 1.0177 200.053 Low confidence
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891] 1873 199.455 1.01985 203.414
2922 0.00001 1 0.00001 High confidence
130 kda leucine-rich protein (lrp 130) (gp130) (leucine-rich ppr-motif containing protein). [swissprot;acc:p42704] 4255 200.395 1.00954 202.306 Low confidence
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946] 2076 194.83 1.01928 198.587
2439 221.425 1.00337 220.681 High confidence
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655] 2864 197.043 1.01713 200.418 Low confidence
3088 0.00001 1 0.00001 High confidence
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312] 2108 194.902 1.01923 198.65 Low confidence
2396 221.51 1.00375 220.683 High confidence
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758] 1044 196.966 1.02415 201.723 Low confidence
2366 202.529 1.00407 203.353 High confidence
15 kda selenoprotein precursor. [swissprot;acc:o60613] 1948 212.432 1.00984 214.522
4465 201.104 1.00907 202.928 Low confidence
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428] 2855 0.00001 1 0.00001 High confidence
4126 195.778 1.01062 197.858 Low confidence
16.7kd protein. [refseq;acc:nm_016139] 3267 195.864 1.01575 198.949
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034] 1051 217.998 1.03097 211.449 High confidence
1803 195.655 1.02012 199.592 Low confidence
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829] 627 10050.9 1.02953 0 10347.7
2142 192.884 1.01915 1 196.577
2,4-dienoyl coa reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-coa reductase. [refseq;acc:nm_020664] 3846 198.422 1.01306 201.014
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor (ec 2.4.1.45) (udp-galactose-ceramide galactosyltransferase) (ceramide udp-galactosyltransferase) (cerebroside synthase). [swissprot;acc:q16880] 4455 205.097 1.00928 207
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83] 941 201.99 1.02493 207.026
2007 222.969 1.00919 225.019 High confidence
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218] 994 196.729 1.02457 201.562 Low confidence
1160 214.041 1.02633 208.55 High confidence
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694] 1484 202.726 1.0191 198.927
4541 201.202 1.00806 202.824 Low confidence
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953] 1389 213.875 1.02148 218.47 High confidence
1439 198.891 1.0217 203.206 Low confidence
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298] 183 198.011 1.153 228.306 High confidence
276 191.474 1.04421 199.939 Low confidence
25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811] 1085 199.188 1.02382 203.933

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/