Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank description Network Comparison Type Value Type Filtered green Interaction Map network_comparison red
Results: HTML CSV LaTeX Showing element 551 to 600 of 9634 in total
Network Comparison Type  : Divided
Value Type  : Ranked
Rank
description
Filtered
green
Interaction Map
network_comparison
red
138 transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802] 1 205.4 Low confidence 1.0631 218.36
zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782] 0 7516 1.16152 8730
139 alpha crystallin a chain. [swissprot;acc:p02489] 13972.2 High confidence 1.17178 16372.4
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410] 1 225.68 1.20415 271.752
glutathione s-transferase theta 2 (ec 2.5.1.18) (gst class-theta). [swissprot;acc:p30712] 0 10962.4 Low confidence 1.16001 12716.5
testican-1 precursor (spock protein). [swissprot;acc:q08629] 1 234.111 1.06291 220.254
140 mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 0 14027.1 High confidence 1.17001 16411.9
ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570] 1 49 1.20408 59
spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6] 0 7533.54 Low confidence 1.15539 6520.34
testican-2 precursor. [swissprot;acc:q92563] 1 234.047 1.06278 220.222
141 probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185] 0 8991.19 High confidence 1.1692 7690.02
ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157] 1 49 1.20408 59
rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155] 206.52 Low confidence 1.0621 219.344
transcription initiation factor iie, beta subunit (tfiie-beta). [swissprot;acc:p29084] 0 15652 1.15506 18079
142 endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ec 3.2.1.113) (er alpha-1,2-mannosidase) (mannosidase alpha class 1b member 1) (man9glcnac2-specific processing alpha-mannosidase). [swissprot;acc:q9ukm7] 1 198.732 1.06201 211.056
ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064] 49 High confidence 1.20408 59
voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02] 0 7026.41 1.16908 8214.41
zinc finger protein 183-like 1. [refseq;acc:nm_178861] 12382.9 Low confidence 1.15505 10720.7
143 anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685] 1 49 High confidence 1.20408 59
dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743] 0 16782.2 Low confidence 1.15502 14529.8
dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959] 13005.3 High confidence 1.16904 11124.8
presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810] 1 198.732 Low confidence 1.06201 211.056
144 dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325] 0 13000.1 High confidence 1.16872 11123.4
f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315] 1 198.732 Low confidence 1.06201 211.056
kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] 319.651 High confidence 1.20312 265.686
l-lactate dehydrogenase a chain (ec 1.1.1.27) (ldh-a) (ldh muscle subunit) (ldh-m). [swissprot;acc:p00338] 0 16094.8 Low confidence 1.1548 18586.3
145 metaxin 1. [swissprot;acc:q13505] 12622.6 1.15433 10935
potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] 1 319.546 High confidence 1.20293 265.639
presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768] 198.732 Low confidence 1.06201 211.056
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] 0 6817.49 High confidence 1.16694 7955.61
146 coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606] 14662.1 1.16571 12577.8
kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] 1 319.531 1.20291 265.632
macrophage mannose receptor precursor (mmr) (cd206 antigen). [swissprot;acc:p22897] 0 9167.67 Low confidence 1.15085 7966.03
nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181] 1 213.661 1.06193 226.892
147 60s ribosomal protein l7. [swissprot;acc:p18124] 0 9505.89 High confidence 1.16562 11080.3
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] 1 42.3003 1.2009 50.7983
pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278] 0 9133.64 Low confidence 1.14991 7942.9
rho guanine nucleotide exchange factor 6 (pak-interacting exchange factor alpha) (alpha-pix) (cool-2). [swissprot;acc:q15052] 1 206.507 1.06182 219.273
148 dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6] 0 9368.39 1.14979 10771.7
sad1/unc-84 protein-like 1. [swissprot;acc:o94901] 1 247.559 High confidence 1.19841 296.677
sentrin-specific protease 8 (ec 3.4.22.-) (sentrin/sumo-specific protease senp8) (cysteine protease fksg8). [swissprot;acc:q96ld8] 198.33 Low confidence 1.06176 210.579
spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6] 0 7863.63 High confidence 1.164 6755.71
149 atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] 1 170 1.19718 142
block 23. [sptrembl;acc:q8nhw5] 0 13334.8 1.16265 11469.3
sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772] 8262.77 Low confidence 1.1491 7190.64
ubiquitin-like protein nedd8. [swissprot;acc:q15843] 1 198.33 1.06176 210.579
150 myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0] 46 High confidence 1.19565 55
serine/threonine-protein kinase plk (ec 2.7.1.-) (plk-1) (serine- threonine protein kinase 13) (stpk13). [swissprot;acc:p53350] 194.554 Low confidence 1.06148 206.516
synaptosomal-associated protein 23 (snap-23) (vesicle-membrane fusion protein snap-23). [swissprot;acc:o00161] 0 12769.9 1.14781 11125.4
zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782] 7516 High confidence 1.16152 8730

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/