MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	Value Type	Network Comparison Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 201 to 250 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	Network Comparison Type	description	network_comparison	red	green
26	Measured	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	2.0534	1833.01	892.67
		Subtracted	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	5430.7	23693.7	18263
	Ranked	Divided	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	1.31818	58	44
		Subtracted	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	69	322	253
	Squared	Divided	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	3.18404	143.692	457.521
		Subtracted	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	89286	219048	129762
	Rooted	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	1.66024	40.3362	24.2954
		Subtracted	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	20.106	146.94	167.046
27	Measured	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	2.04922	1834.33	895.134
		Subtracted	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	5430.7	23693.7	18263
	Ranked	Divided	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	1.31818	58	44
		Subtracted	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	68.941	267.136	336.077
	Squared	Divided	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	3.18404	143.692	457.521
		Subtracted	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	89286	219048	129762
	Rooted	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	1.66015	40.3364	24.2968
		Subtracted	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	20.106	146.94	167.046
28	Measured	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	2.04912	1834.36	895.194
		Subtracted	necdin. [swissprot;acc:q99608]	5430.7	23693.7	18263
	Ranked	Divided	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	1.31416	201.949	153.671
		Subtracted	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	68.941	267.136	336.077
	Squared	Divided	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	3.18404	143.692	457.521
		Subtracted	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	89286	219048	129762
	Rooted	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	1.65967	40.3372	24.3043
		Subtracted	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	19.466	149.165	129.699
29	Measured	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	2.04858	1834.52	895.507
		Subtracted	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	5430.7	23693.7	18263
	Ranked	Divided	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	1.29991	187.458	243.678
		Subtracted	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	68.936	267.139	336.075
	Squared	Divided	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	3.18404	143.692	457.521
		Subtracted	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	89286	219048	129762
	Rooted	Divided	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	1.65937	26.0288	43.1914
		Subtracted	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	18.763	210.928	192.165
30	Measured	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	2.04837	1834.59	895.633
		Subtracted	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	5430.7	23693.7	18263
	Ranked	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	1.29991	187.457	243.678
		Subtracted	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	68.935	267.14	336.075
	Squared	Divided	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	3.18404	143.692	457.521
		Subtracted	trophinin. [swissprot;acc:q12816]	89286	219048	129762
	Rooted	Divided	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	1.65937	26.0288	43.1914
		Subtracted	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	18.7077	60.8022	79.5099
31	Measured	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	2.04827	1834.63	895.697
		Subtracted	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	5430.7	23693.7	18263
	Ranked	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	1.2999	187.458	243.677
		Subtracted	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	68.935	267.14	336.075
	Squared	Divided	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	2.53372	9924.76	25146.6
		Subtracted	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	85915	106226	192141
	Rooted	Divided	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	1.65937	26.0288	43.1914
		Subtracted	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	18.7028	40.0958	58.7986
32	Measured	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	2.04793	1834.73	895.893
		Subtracted	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	5430.7	23693.7	18263

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.