MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	description	Interaction Map	Gene	Value Type	green	Rank	red	network_comparison	Network Comparison Type

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Showing element 1 to 50 of 38536 in total

Filtered  : 0
Network Comparison Type  : Divided

description	Interaction Map	Value Type	green	Rank	red	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	High confidence	Measured	934.348	37	334.401	2.79409
		Ranked	13895.8	242	15260.6	1.09822
		Squared	1034.13	37	101.05	10.2338
		Rooted	18.0183	53	11.844	1.5213
	Low confidence	Measured	851.77	131	645.504	1.31954
		Ranked	13590.3	629	13205.3	1.02915
		Squared	1268.51	146	775.72	1.63527
		Rooted	17.0804	537	16.298	1.04801
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]		Measured	4869.42	778	4825.89	1.00902
		Ranked	10050.9	627	10347.7	1.02953
		Squared	40451	815	40270.8	1.00447
		Rooted	39.5126	768	39.0982	1.0106
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	High confidence	Measured	26.1599	19	305.45	11.6763
		Ranked	18499.2	47	12941.7	1.42943
		Squared	0.344399	26	44.3683	128.828
		Rooted	3.80565		13.7805	3.62106
	Low confidence	Measured	181.734	171	222.779	1.22585
		Ranked	14695.2	384	13533.1	1.08587
		Squared	296.481	697	307.765	1.03806
		Rooted	9.42485	131	11.365	1.20585
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	High confidence	Measured	2642.79	451	2683.61	1.01545
		Ranked	10806	379	11228.4	1.03909
		Squared	7355.46	316	8620.27	1.17196
		Rooted	32.0298	370	30.7424	1.04188
	Low confidence	Measured	1609.88	771	1593.68	1.01017
		Ranked	11854.2	825	11832.8	1.00181
		Squared	6490.54	763	6603.33	1.01738
		Rooted	23.2445	793	23.11	1.00582
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	High confidence	Measured	2263.85	474	2281.12	1.00763
		Ranked	11748.1	495	11725.2	1.00195
		Squared	5878.56	328	6747.71	1.14785
		Rooted	28.5146	458	28.0847	1.01531
	Low confidence	Measured	2331.31	785	2349.9	1.00797
		Ranked	11538	665	11801.6	1.02285
		Squared	14694	591	15800.9	1.07533
		Rooted	26.5693	728	26.1642	1.01548
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	High confidence	Measured	5046.33	492	5038.33	1.00159
		Ranked	11512.3	299	12338.7	1.07178
		Squared	17901.1	493	17901.1	1
		Rooted	44.9836	438	43.8864	1.025
	Low confidence	Measured	5046.33	822	5038.33	1.00159
		Ranked	11512.3	453	12338.7	1.07178
		Squared	17901.1	836	17901.1	1
		Rooted	44.9836	662	43.8864	1.025
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	High confidence	Measured	2853.65	438	2925.57	1.0252
		Ranked	10466.5	327	9897.29	1.05751
		Squared	18218.3	477	18353.1	1.0074
		Rooted	31.1453	376	32.3671	1.03923
	Low confidence	Measured	1932.95	581	2015.65	1.04278
		Ranked	11352.1	501	10721.7	1.0588

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.