Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Rank Gene Interaction Map description Filtered network_comparison green red Network Comparison Type
Results: HTML CSV LaTeX Showing element 601 to 650 of 38536 in total
Value Type  : Measured
Network Comparison Type  : Divided
Rank
Interaction Map
description
Filtered
network_comparison
green
red
151 High confidence sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] 1 1.29746 5939.91 4578.09
udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795] 0 1.28932 1729.7 2230.13
Low confidence cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2] 1 1.08628 7751.87 7136.14
williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645] 0 1.26808 323.685 410.457
152 High confidence melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 1 1.29736 18263 23693.7
udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310] 0 1.28932 1729.7 2230.13
Low confidence cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 1.26579 5898.71 4660.09
nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323] 1 1.08627 6016.13 5538.35
153 High confidence hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703] 1.29736 18263 23693.7
udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133] 0 1.28932 1729.7 2230.13
Low confidence candidate tumor suppressor protein. [refseq;acc:nm_020381] 1.26419 2821.67 2232
nipsnap1 protein. [swissprot;acc:q9bpw8] 1 1.08611 6022.42 5544.97
154 High confidence glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075] 0 1.28932 1729.7 2230.13
melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 1 1.29736 18263 23693.7
Low confidence monocarboxylate transporter 8 (mct 8) (x-linked pest-containing transporter) (mct 7). [swissprot;acc:p36021] 1.08517 11452.8 10553.9
supervillin isoform 1; membrane-associated f-actin binding protein p205; archvillin. [refseq;acc:nm_003174] 0 1.26419 2821.67 2232
155 High confidence melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] 1 1.29736 18263 23693.7
udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537] 0 1.28932 1729.7 2230.13
Low confidence cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] 1.26273 5341.81 4230.36
solute carrier family 16 (monocarboxylic acid transporters), member 10; t-type amino acid transporter 1. [refseq;acc:nm_018593] 1 1.08517 11452.6 10553.7
156 High confidence melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 1.29736 18263 23693.7
udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855] 0 1.28932 1729.7 2230.13
Low confidence protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 1.25858 2118.44 1683.2
tho complex 3. [refseq;acc:nm_032361] 1 1.08467 8028.16 7401.51
157 High confidence hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 1.29736 18263 23693.7
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 0 1.28908 336.584 261.105
Low confidence brca1 associated protein. [refseq;acc:nm_006768] 1.25567 1403.03 1117.36
vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754] 1 1.08462 8131.56 7497.17
158 High confidence guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388] 0 1.28508 1649.37 1283.48
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 1 1.29736 18263 23693.7
Low confidence mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749] 1.08416 6976.28 6434.71
rho guanine nucleotide exchange factor (gef) 12; leukemia-associated rho guanine nucleotide exchange factor. [refseq;acc:nm_015313] 0 1.25474 944.615 752.839
159 High confidence lipocalin-interacting membrane receptor. [refseq;acc:nm_018113] 1.27796 574.372 734.025
necdin. [swissprot;acc:q99608] 1 1.29736 18263 23693.7
Low confidence brain protein 44. [swissprot;acc:o95563] 1.08349 11259.7 10392.1
dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2] 0 1.25423 612.604 488.43
160 High confidence huntingtin interacting protein c. [refseq;acc:nm_012272] 1.27566 1296.38 1653.74
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 1 1.29736 18263 23693.7
Low confidence methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898] 1.08304 11320.8 10452.8
testican-3 precursor. [swissprot;acc:q9bq16] 0 1.25401 805.916 642.672
161 High confidence glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434] 1.27473 1152.06 903.767
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 1 1.29736 18263 23693.7
Low confidence monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375] 1.08298 11210.8 10351.8
protein c20orf142 precursor. [swissprot;acc:q8n6m3] 0 1.25 95 76
162 High confidence cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 1.26468 7252.02 5734.28
melanoma antigen, family b, 6. [refseq;acc:nm_173523] 1 1.29736 18263 23693.7
Low confidence cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247] 0 1.24887 1107 1382.5
cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] 1 1.08298 11472.3 12424.3
163 High confidence melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] 1.29736 18263 23693.7
myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] 0 1.26442 6193.07 7830.62

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/