Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Filtered Gene Value Type network_comparison Rank green description Interaction Map Network Comparison Type red
Results: HTML CSV LaTeX Showing element 501 to 550 of 29840 in total
Filtered  : 0
Value Type  : Measured
Interaction Map  : High confidence
network_comparison
Rank
green
description
Network Comparison Type
red
3.04255 34 47 glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] Divided 143
3.072 466 796.85 sprouty homolog 4 (spry-4). [swissprot;acc:q9c004] Subtracted 793.778
3.15402 33 39.8063 lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] Divided 12.6208
3.25 32 184 cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336] 598
3.82335 30 111.739 dystrophin. [swissprot;acc:p11532] 427.217
3.901 465 151.122 alpha-nac protein. [sptrembl;acc:q9h009] Subtracted 147.221
3.90833 29 434.911 potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] Divided 111.278
4 464 19 adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559] Subtracted 23
4.087 463 150.709 nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594] 146.622
4.10072 27 139 phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] Divided 570
28 beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]
4.3268 26 662 fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] 153
4.687 462 701.071 survival motor neuron protein (component of gems 1) (gemin1). [swissprot;acc:q16637] Subtracted 705.758
5.015 461 604.911 transcription initiation factor tfiid 20/15 kda subunits (tafii- 20/tafii-15) (tafii20/tafii15). [swissprot;acc:q16514] 599.896
5.22297 25 773 potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110] Divided 148
5.26667 24 158 ptd016 protein. [refseq;acc:nm_016125] 30
5.3334 460 14.3333 4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404] Subtracted 19.6667
5.5 459 206.5 testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562] 201
6.73106 21 17.6611 syntaxin 10 (syn10). [swissprot;acc:o60499] Divided 118.878
7.7 458 1310.67 adenylosuccinate synthase-like 1. [refseq;acc:nm_152328] Subtracted 1318.37
8 457 5046.33 3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8] 5038.33
8.1 456 226.81 glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410] 218.71
8.112 455 227.143 glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409] 219.031
8.118 454 227.308 glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189] 219.19
8.821 453 533.236 protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237] 524.415
9.32 452 219.891 60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] 229.211
9.76 451 1372.31 dead/h (asp-glu-ala-asp/his) box polypeptide 11; dead/h box-11 (chl1-related helicase gene-1); yeast chl1 homolog. [refseq;acc:nm_030655] 1362.55
11.6763 18 26.1599 60s ribosomal protein l37a. [swissprot;acc:p12751] Divided 305.45
19 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]
12 450 43 methyltransferase like 2. [refseq;acc:nm_018396] Subtracted 31
13.333 449 546 protein c20orf45 (cgi-107). [swissprot;acc:q9y3b1] 532.667
13.498 448 156.3 syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623] 142.802
13.501 447 485.852 tbp-associated factor 9l; neuronal cell death-related protein; taf9-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 31 kd; neuronal cell death-related gene in neuron-7; transcription associated factor tafii31l; transcription initiation factor iid, 31kd subunit. [refseq;acc:nm_015975] 472.351
13.8767 446 37.4843 suppressor of actin 1. [refseq;acc:nm_014016] 23.6076
14 442 56 maspin precursor (protease inhibitor 5). [swissprot;acc:p36952] 42
443 15 protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992] 1
444 56 serpin b11. [swissprot;acc:q96p15] 42
445 cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
14.077 440 149.371 forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488] 135.294
441 interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]
14.51 439 1248.14 dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374] 1262.65
14.553 438 161.091 dead (asp-glu-ala-asp) box polypeptide 47; hqp0256 protein. [refseq;acc:nm_016355] 175.644
14.8103 17 58 mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849] Divided 859
15 16 15 protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992] 1
15.287 437 476.639 importin 4. [refseq;acc:nm_024658] Subtracted 491.926
15.6 15 156 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521] Divided 10
15.88 436 1483.62 ischemia/reperfusion inducible protein. [refseq;acc:nm_024640] Subtracted 1467.74
16.74 435 2335.98 alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652] 2319.24
17.27 434 2263.85 26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232] 2281.12
17.465 433 359.98 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] 377.445

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/