MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	Value Type	Gene	Network Comparison Type	green	network_comparison	red	Interaction Map	Rank	description

Results: HTML CSV LaTeX

Showing element 501 to 550 of 77072 in total

Filtered  : 0
Value Type  : Measured
Network Comparison Type  : Divided

green	network_comparison	red	Interaction Map	Rank	description
958.726	1.05539	1011.83	Low confidence	524	keratin associated protein 1.5. [refseq;acc:nm_031957]
				525	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]
958.728				522	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]
				526	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]
958.732	1.05538			527	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]
958.745	1.05537			531	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]
				532	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]
958.748	1.05538	1011.84		528	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]
958.749				529	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]
958.753	1.05537			530	similar to peptidylprolyl isomerase a (cyclophilin a); cyclophilin-lc; cyclophilin homolog overexpressed in liver cancer; chromosome 1 amplified sequence 2. [refseq;acc:nm_178230]
959.463	1.05484	1012.08		536	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]
961.098	1.00278	958.429	High confidence	484	scribble. [refseq;acc:nm_015356]
965.202	1.2878	749.494	Low confidence	144	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]
969.022	1.00304	966.085		810	elongation factor 1-alpha 1 (ef-1-alpha-1) (elongation factor 1 a-1) (eef1a-1) (elongation factor tu) (ef-tu). [swissprot;acc:p04720]
971.37	1.00552	976.734		794	dystrophin. [swissprot;acc:p11532]
975	1.5625	624		90	rna transcribed from l1 repetitive element (shr4) (fragment). [sptrembl;acc:q9y443]
				91	putative p150. [sptrembl;acc:o00370]
				92	lamin-like protein in hindiii repetitive element derived dna, 3' end (fragment). [sptrembl;acc:q14755]
				93	line-1 reverse transcriptase (fragment). [sptrembl;acc:o00172]
975.647	1.12024	870.93	High confidence	277	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]
			Low confidence	367
977	1.47595	1442	High confidence	101	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]
				102	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]
988.882	1.06044	1048.65		369	dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325]
989.438	1.06041	1049.21		370	dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959]
991.072	1.11025	1100.34	Low confidence	391	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]
992.083	1.73441	572	High confidence	72	60s ribosomal protein l21. [swissprot;acc:p46778]
994.275	1.02465	1018.78	Low confidence	662	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]
1005.42	1.09699	916.527		411	mitochondrial ribosomal protein l38. [refseq;acc:nm_032478]
1006.57	1.00558	1012.19		792	dj850e9.1 (novel c2h2 type zinc finger protein similar to drosophila scratch (scrt), slug and xenopus snail) (fragment). [sptrembl;acc:q9nq03]
1010.2	1.06023	952.812		498	solute carrier family 4, sodium bicarbonate cotransporter, member 8. [refseq;acc:nm_004858]
1011.49	1.01291	1024.55		745	tera protein. [refseq;acc:nm_021238]
1011.67	1.37602	1392.08		112	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]
1015.49	1.00479	1020.35		798	scratch; scratch 1. [refseq;acc:nm_031309]
1020.78	1.16449	876.587		315	dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959]
1020.84	1.16456			314	dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325]
1023.76	1.22025	1249.24	High confidence	189	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]
1026.18	1.19915	1230.54		199	glutamine synthetase (ec 6.3.1.2) (glutamate--ammonia ligase). [swissprot;acc:p15104]
1035.81	1.03681	1073.94	Low confidence	599	60s ribosomal protein l15. [swissprot;acc:p39030]
1036.1	1.10804	1148.04		393	dynamin-like 120 kda protein, mitochondrial precursor (optic atrophy 1 gene protein). [swissprot;acc:o60313]
1049.11	1.36592	768.061		114	calponin h2, smooth muscle (neutral calponin). [swissprot;acc:q99439]
1060	1.05047	1113.5		558	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]
				559	histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]
				560	histone h2a; h2a histone family, member r. [refseq;acc:nm_170745]
				561	h2a histone family, member j isoform 1. [refseq;acc:nm_018267]
1061.23	1.04494	1108.92		576	solute carrier family 12 (potassium/chloride transporters), member 9; cation-chloride cotransporter-interacting protein. [refseq;acc:nm_020246]
1063.6	1.2107	1287.7		183	regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]
1066.67	1.03569	1104.74		602	alpha 2 globin. [refseq;acc:nm_000517]
1067.65	1.03559	1105.65		604	hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096]
1068	1.75947	607	High confidence	70	importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [swissprot;acc:p52292]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.