MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	description	Network Comparison Type	Rank	Interaction Map	red	Value Type	green	network_comparison	Filtered

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	red	Value Type	green	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Divided	18	185.678	Ranked	245.247	1.32082
		60	4489.19	Measured	2765.82	1.6231
		64	63.8686	Rooted	47.2654	1.35128
		245	8875.01	Squared	6768.05	1.31131
	Subtracted	54	185.678	Ranked	245.247	59.569
		67	63.8686	Rooted	47.2654	16.6032
		164	4489.19	Measured	2765.82	1723.37
		1962	8875.01	Squared	6768.05	2106.96
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Divided	295	30807.7		39351.7	1.27733
		509	7551.8	Measured	8630.06	1.14278
		805	74.3557	Rooted	79.1513	1.0645
		1038	186.741	Ranked	181.041	1.03148
	Subtracted	274	30807.7	Squared	39351.7	8544
		310	7551.8	Measured	8630.06	1078.26
		610	74.3557	Rooted	79.1513	4.7956
		1120	186.741	Ranked	181.041	5.7
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Divided	294	30826.5	Squared	39383.9	1.2776
		508	7556.75	Measured	8636.87	1.14293
		804	74.3877	Rooted	79.1931	1.0646
		1032	186.664	Ranked	180.943	1.03162
	Subtracted	273	30826.5	Squared	39383.9	8557.4
		307	7556.75	Measured	8636.87	1080.12
		609	74.3877	Rooted	79.1931	4.8054
		1115	186.664	Ranked	180.943	5.721
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Divided	311	30566.4	Squared	38866.5	1.27154
		514	7477	Measured	8532.02	1.1411
		822	73.8577	Rooted	78.5795	1.06393
		1048	187.96	Ranked	182.308	1.031
	Subtracted	280	30566.4	Squared	38866.5	8300.1
		319	7477	Measured	8532.02	1055.02
		631	73.8577	Rooted	78.5795	4.7218
		1128	187.96	Ranked	182.308	5.652
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Divided	308	30596.2	Squared	38919.9	1.27205
		513	7485.08	Measured	8543.66	1.14143
		811	73.9102	Rooted	78.6514	1.06415
		1043	187.834	Ranked	182.137	1.03128
	Subtracted	279	30596.2	Squared	38919.9	8323.7
		318	7485.08	Measured	8543.66	1058.58
		616	73.9102	Rooted	78.6514	4.7412
		1121	187.834	Ranked	182.137	5.697
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Divided	3126	0.00001	Measured	0.00001	1
				Ranked
				Squared
				Rooted
	Subtracted		0	Measured	0	0
				Ranked
				Squared
				Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	Divided	588	23526.4	Squared	27879.3	1.18502
		1136	5790.65	Measured	6303.92	1.08864

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.