Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Rank description Value Type Network Comparison Type Interaction Map Filtered green red network_comparison
Results: HTML CSV LaTeX Showing element 1930 to 1979 of 3228 in total 
Value Type	Ranked
Network Comparison Type	Divided
Interaction Map	High confidence
Filtered	1

Rank	description	green	red	network_comparison	
1930	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [source:swissprot;acc:p18577]	198.935	196.964	1.01001	
1931	eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [source:swissprot;acc:o15371]	217.574	219.753	1.01001	
1932	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [source:swissprot;acc:p18577]	198.936	196.965	1.01001	
1933	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [source:swissprot;acc:p00480]	217.82	215.667	1.00998	
1934	gamma adducin (adducin-like protein 70). [source:swissprot;acc:q9uey8]	222.055	224.264	1.00995	
1935	abhydrolase domain containing protein 2 (protein phps1-2). [source:swissprot;acc:p08910]	216.279	218.43	1.00995	
1936	creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [source:swissprot;acc:p17540]	196.347	198.3	1.00995	
1937	quaking isoform 6. [source:sptrembl;acc:q9p0x9]	216.279	218.43	1.00995	
1938	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [source:swissprot;acc:p12532]	196.341	198.293	1.00994	
1939	peptidyl prolyl isomerase h; cyclophilin h. [source:refseq;acc:nm_006347]	196.319	198.258	1.00988	
1940	creatine kinase, b chain (ec 2.7.3.2) (b-ck). [source:swissprot;acc:p12277]	196.252	198.19	1.00988	
1941	prp18 pre-mrna processing factor 18 homolog. [source:refseq;acc:nm_003675]	196.319	198.258	1.00988	
1942	j domain protein c21orf55. [source:swissprot;acc:q9nx36]	196.319	198.257	1.00987	
1943	megf11 protein. [source:refseq;acc:nm_032445]	222.147	224.34	1.00987	
1944	megf10 protein. [source:refseq;acc:nm_032446]	222.148	224.341	1.00987	
1945	beta adducin (erythrocyte adducin beta subunit). [source:swissprot;acc:p35612]	222.151	224.343	1.00987	
1946	nuclear factor, interleukin 3 regulated. [source:refseq;acc:nm_005384]	212.142	214.234	1.00986	
1947	protein phosphatase inhibitor 2 (ipp-2). [source:swissprot;acc:p41236]	127.083	125.845	1.00984	
1948	15 kda selenoprotein precursor. [source:swissprot;acc:o60613]	212.432	214.522	1.00984	
1949	rna-binding protein with multiple splicing (rbp-ms). [source:swissprot;acc:q93062]	216.663	218.794	1.00984	
1950	vacuolar protein sorting 18 (hvps18). [source:swissprot;acc:q9p253]	213.747	215.847	1.00982	
1951	trna isopentenylpyrophosphate transferase. [source:refseq;acc:nm_017646]	203.873	205.876	1.00982	
1952	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [source:swissprot;acc:p52294]	213.724	211.647	1.00981	
1953	type 1 protein phosphatase inhibitor. [source:refseq;acc:nm_025210]	127.146	125.912	1.0098	
1954	voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [source:swissprot;acc:o43448]	213.703	211.632	1.00979	
1955	yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [source:refseq;acc:nm_020470]	213.703	211.633	1.00978	
1956	voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [source:swissprot;acc:q14722]	213.703	211.633	1.00978	
1957	similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [source:refseq;acc:nm_033557]	213.703	211.633	1.00978	
1958	aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [source:swissprot;acc:o95154]	213.703	211.633	1.00978	
1959	alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [source:refseq;acc:nm_138340]	213.703	211.633	1.00978	
1960	golgi membrane protein sb140; smooth muscle cell associated protein 5. [source:refseq;acc:nm_030799]	213.703	211.633	1.00978	
1961	alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [source:refseq;acc:nm_152870]	213.703	211.633	1.00978	
1962	methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [source:swissprot;acc:q02252]	213.702	211.632	1.00978	
1963	10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [source:swissprot;acc:q04984]	213.703	211.633	1.00978	
1964	rab acceptor 1 (prenylated); prenylated rab acceptor 1. [source:refseq;acc:nm_006423]	213.703	211.633	1.00978	
1965	alpha adducin (erythrocyte adducin alpha subunit). [source:swissprot;acc:p35611]	222.258	224.432	1.00978	
1966	oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [source:swissprot;acc:q9y3b8]	213.703	211.633	1.00978	
1967	choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [source:swissprot;acc:p28329]	213.702	211.632	1.00978	
1968	voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [source:swissprot;acc:q13303]	213.703	211.633	1.00978	
1969	aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [source:swissprot;acc:o43488]	213.703	211.633	1.00978	
1970	importin alpha-6 subunit (karyopherin alpha-5 subunit). [source:swissprot;acc:o15131]	213.683	211.62	1.00975	
1971	creatine kinase, m chain (ec 2.7.3.2) (m-ck). [source:swissprot;acc:p06732]	196.346	198.258	1.00974	
1972	regucalcin gene promotor region related protein; rgpr-p117. [source:refseq;acc:nm_033127]	217.659	219.777	1.00973	
1973	wiskott-aldrich syndrome protein family member 2 (wasp-family protein member 2) (verprolin homology domain-containing protein 2). [source:swissprot;acc:q9y6w5]	212.546	214.611	1.00972	
1974	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [source:swissprot;acc:q9upy6]	212.546	214.611	1.00972	
1975	wiskott-aldrich syndrome protein family member 1 (wasp-family protein member 1) (verprolin homology domain-containing protein 1). [source:swissprot;acc:q92558]	212.546	214.611	1.00972	
1976	rest corepressor. [source:refseq;acc:nm_015156]	212.546	214.611	1.00972	
1977	homolog of yeast maf1. [source:refseq;acc:nm_032272]	207.529	209.539	1.00969	
1978	tumor differentially expressed protein 2. [source:refseq;acc:nm_178865]	207.529	209.539	1.00969	
1979	tumor differentially expressed protein 1 (transmembrane protein sbbi99). [source:swissprot;acc:q13530]	207.529	209.539	1.00969	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/