Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank Gene Value Type Network Comparison Type Filtered description Interaction Map green red network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 12912 in total

Network Comparison Type	Divided
Filtered	1
Interaction Map	High confidence

Rank	Value Type	description	green	red	network_comparison	
13	Squared	cytoplasmic polyadenylation element binding protein 3. [source:refseq;acc:nm_014912]	388.696	37.5863	10.3414	
13	Rooted	cytoplasmic polyadenylation element binding protein 3. [source:refseq;acc:nm_014912]	35.798	19.9625	1.79326	
14	Measured	ras gtpase-activating protein ngap (ras protein activator like 1). [source:swissprot;acc:q9ujf2]	1281.5	398.5	3.21581	
14	Ranked	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [source:refseq;acc:nm_052936]	75.3531	56.6768	1.32952	
14	Squared	ras gtpase-activating protein ngap (ras protein activator like 1). [source:swissprot;acc:q9ujf2]	388.696	37.5863	10.3414	
14	Rooted	ras gtpase-activating protein ngap (ras protein activator like 1). [source:swissprot;acc:q9ujf2]	35.798	19.9625	1.79326	
15	Measured	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [source:refseq;acc:nm_007266]	871	2671	3.06659	
15	Ranked	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [source:swissprot;acc:q9gzq8]	75.3948	56.7244	1.32914	
15	Squared	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [source:refseq;acc:nm_007266]	179.56	1688.58	9.40399	
15	Rooted	gbp protein isoform a. [source:refseq;acc:nm_017870]	42.4773	23.9771	1.77158	
16	Measured	protein x 0004. [source:refseq;acc:nm_016301]	871	2671	3.06659	
16	Ranked	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [source:swissprot;acc:q9h492]	75.3954	56.7252	1.32913	
16	Squared	protein x 0004. [source:refseq;acc:nm_016301]	179.56	1688.58	9.40399	
16	Rooted	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [source:refseq;acc:nm_007266]	29.5127	51.6817	1.75117	
17	Measured	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [source:swissprot;acc:q96df8]	1365	460	2.96739	
17	Ranked	cysteine endopeptidase aut-like isoform b. [source:refseq;acc:nm_178326]	75.447	56.7841	1.32866	
17	Squared	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [source:swissprot;acc:q96df8]	441	50.0828	8.80542	
17	Rooted	protein x 0004. [source:refseq;acc:nm_016301]	29.5127	51.6817	1.75117	
18	Measured	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [source:refseq;acc:nm_033256]	1865.5	677.5	2.75351	
18	Ranked	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [source:swissprot;acc:q04446]	245.247	185.678	1.32082	
18	Squared	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [source:refseq;acc:nm_033256]	823.69	108.641	7.58176	
18	Rooted	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [source:swissprot;acc:q96df8]	36.9459	21.4476	1.72261	
19	Measured	microfibril-associated glycoprotein 4 precursor. [source:swissprot;acc:p55083]	1865.5	677.5	2.75351	
19	Ranked	glycogen phosphorylase, brain form (ec 2.4.1.1). [source:swissprot;acc:p11216]	245.247	185.678	1.32082	
19	Squared	microfibril-associated glycoprotein 4 precursor. [source:swissprot;acc:p55083]	823.69	108.641	7.58176	
19	Rooted	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [source:refseq;acc:nm_003690]	43.561	25.6987	1.69507	
20	Measured	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [source:refseq;acc:nm_017726]	1865.5	677.5	2.75351	
20	Ranked	glycogen phosphorylase, liver form (ec 2.4.1.1). [source:swissprot;acc:p06737]	245.247	185.678	1.32082	
20	Squared	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [source:refseq;acc:nm_017726]	823.69	108.641	7.58176	
20	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [source:swissprot;acc:o60262]	24.2744	40.3337	1.66157	
21	Measured	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [source:swissprot;acc:q15485]	1865.5	677.5	2.75351	
21	Ranked	myosin xv (unconventional myosin-15). [source:swissprot;acc:q9ukn7]	245.247	185.678	1.32082	
21	Squared	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [source:swissprot;acc:q15485]	823.69	108.641	7.58176	
21	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [source:swissprot;acc:q9ubi6]	24.2744	40.3337	1.66157	
22	Measured	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [source:refseq;acc:nm_030949]	1865.5	677.5	2.75351	
22	Ranked	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [source:swissprot;acc:p11217]	245.247	185.678	1.32082	
22	Squared	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [source:refseq;acc:nm_030949]	823.69	108.641	7.58176	
22	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [source:swissprot;acc:p50150]	24.2915	40.3357	1.66049	
23	Measured	gbp protein isoform a. [source:refseq;acc:nm_017870]	1894.39	699.76	2.7072	
23	Ranked	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [source:swissprot;acc:q9y2r5]	44	58	1.31818	
23	Squared	neurogenic differentiation factor 2 (neurod2). [source:swissprot;acc:q15784]	457.521	143.692	3.18404	
23	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [source:swissprot;acc:p29798]	24.2919	40.3358	1.66046	
24	Measured	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [source:refseq;acc:nm_003690]	2108.52	950.561	2.21818	
24	Ranked	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [source:swissprot;acc:q8te04]	44	58	1.31818	
24	Squared	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [source:swissprot;acc:q12873]	457.521	143.692	3.18404	
24	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [source:swissprot;acc:q9uk08]	24.2941	40.336	1.66032	
25	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [source:swissprot;acc:o60262]	892.67	1833.01	2.0534	
25	Ranked	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [source:swissprot;acc:q9bz23]	44	58	1.31818	
25	Squared	doc-1 related protein (doc-1r). [source:swissprot;acc:o75956]	457.521	143.692	3.18404	
25	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [source:swissprot;acc:p30670]	24.295	40.3361	1.66026	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/