Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Rank Value Type Network Comparison Type Filtered description green Interaction Map red network_comparison
Results: HTML CSV LaTeX Showing element 3180 to 3229 of 16578 in total
Value Type  : Ranked
Filtered  : 1
Rank
Network Comparison Type
description
green
Interaction Map
red
network_comparison
795 Subtracted ubiquitin-conjugating enzyme e2-32 kda complementing (ec 6.3.2.19) (ubiquitin-protein ligase) (ubiquitin carrier protein) (e2-cdc34). [swissprot;acc:p49427] 194.573 Low confidence 199.792 5.219
796 Divided grancalcin. [swissprot;acc:p28676] 197.308 202.524 1.02644
placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237] 234.511 High confidence 224.244 1.04578
Subtracted beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115] 221.785 212.386 9.399
rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640] 197.536 Low confidence 202.755 5.219
797 Divided asc-1 complex subunit p100. [refseq;acc:nm_032204] 206.184 211.636 1.02644
cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452] 234.511 High confidence 224.244 1.04578
Subtracted calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632] 197.308 Low confidence 202.525 5.217
syntaxin 16 (syn16). [swissprot;acc:o14662] 221.785 High confidence 212.386 9.399
798 Divided leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740] 234.511 224.244 1.04578
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] 197.308 Low confidence 202.524 1.02644
Subtracted 27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653] 221.785 High confidence 212.386 9.399
grancalcin. [swissprot;acc:p28676] 197.308 Low confidence 202.524 5.216
799 Divided amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] 196.11 201.294 1.02643
sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900] 212.404 High confidence 221.965 1.04501
Subtracted 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643] 201.027 Low confidence 206.243 5.216
syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623] 221.785 High confidence 212.386 9.399
800 Divided nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307] 212.404 221.965 1.04501
rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640] 197.536 Low confidence 202.755 1.02642
Subtracted alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920] 221.785 High confidence 212.386 9.399
dopachrome tautomerase precursor (ec 5.3.3.12) (dt) (dct) (dopachrome delta-isomerase) (tyrosinase-related protein 2) (trp-2) (trp2). [swissprot;acc:p40126] 201.028 Low confidence 206.244 5.216
801 Divided beta-catenin (pro2286). [swissprot;acc:p35222] 214.894 High confidence 224.445 1.04445
programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340] 197.311 Low confidence 202.522 1.02641
Subtracted adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9] 221.785 High confidence 212.386 9.399
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] 197.308 Low confidence 202.524 5.216
802 Divided dc12 protein. [refseq;acc:nm_020187] 198.117 203.345 1.02639
testis-specific protein tex28. [swissprot;acc:o15482] 221.785 High confidence 212.386 1.04425
Subtracted synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721] 9.399
xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7] 196.126 Low confidence 201.338 5.212
803 Divided dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kda subunit precursor (ec 2.4.1.119) (ribophorin i) (rpn-i). [swissprot;acc:p04843] 194.441 199.573 1.02639
similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61] 221.785 High confidence 212.386 1.04425
Subtracted olf-1/ebf associated zinc finger protein; smad- and olf-interacting zinc finger protein. [refseq;acc:nm_015069] 199.711 Low confidence 204.922 5.211
syntaxin 1b. [swissprot;acc:q15531] 221.785 High confidence 212.386 9.399
804 Divided a kindred of iglon. [refseq;acc:nm_173808] 1.04425
elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897] 199.267 Low confidence 204.519 1.02636
Subtracted melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084] 221.785 High confidence 212.386 9.399
programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340] 197.311 Low confidence 202.522 5.211
805 Divided ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1] 221.785 High confidence 212.386 1.04425
synaptojanin 1 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1). [swissprot;acc:o43426] 193.399 Low confidence 198.496 1.02635
Subtracted dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593] 221.785 High confidence 212.386 9.399
early hematopoietic zinc finger. [refseq;acc:nm_015461] 199.706 Low confidence 204.914 5.208
806 Divided inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370] 221.785 High confidence 212.386 1.04425
vacuolar atp synthase subunit c (ec 3.6.3.14) (v-atpase c subunit) (vacuolar proton pump c subunit). [swissprot;acc:p21283] 197.173 Low confidence 202.369 1.02635
Subtracted maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708] 276.773 High confidence 267.447 9.326
mosaic protein lgn. [swissprot;acc:p81274] 202.355 Low confidence 207.56 5.205
807 Divided myofibrillogenesis regulator 1; trans-activated by hepatitis c virus core protein 2; likely ortholog of mouse brain protein 17. [refseq;acc:nm_022572] 195.631 200.782 1.02633
palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897] 221.785 High confidence 212.386 1.04425
Subtracted nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208] 198.706 Low confidence 203.907 5.201
trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102] 227.796 High confidence 218.521 9.275
808 Divided beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115] 221.785 212.386 1.04425

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/