MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Value Type	green	Rank	Filtered	Network Comparison Type	description	network_comparison	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 3180 to 3229 of 38536 in total

Value Type  : Measured
Filtered  : 1
Network Comparison Type  : Divided
Interaction Map  : High confidence

green	Rank	description	network_comparison	red
6215.42	674	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	1.12006	5549.2
	675	sprouty homolog 3 (spry-3). [swissprot;acc:o43610]
	676	sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609]
	677	sprouty homolog 2 (spry-2). [swissprot;acc:o43597]
6217.2	1196	kappa b-ras 1. [refseq;acc:nm_020345]	1.0867	5721.19
	1197	i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]
	1198	snare associated protein snapin. [refseq;acc:nm_012437]
6217.59	682	syntaxin 12. [refseq;acc:nm_177424]	1.1197	5552.92
6218.11	1773	dystrobrevin beta (beta-dystrobrevin) (dtn-b). [swissprot;acc:o60941]	1.06666	5829.51
6218.27	1764	beta-1-syntrophin (59 kda dystrophin-associated protein a1, basic component 1) (dapa1b) (tax interaction protein 43) (tip-43) (syntrophin 2) (bsyn2). [swissprot;acc:q13884]	1.06667	5829.61
	1765	beta-2-syntrophin (59 kda dystrophin-associated protein a1, basic component 2) (syntrophin 3) (snt3) (syntrophin-like) (sntl). [swissprot;acc:q13425]
	1766	nitrilase 1. [refseq;acc:nm_005600]
	1767	utrophin (dystrophin-related protein 1) (drp1) (drp). [swissprot;acc:p46939]
	1768	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (ec 2.3.1.-) (e2) (dihydrolipoamide branched chain transacylase) (bckad e2 subunit). [swissprot;acc:p11182]
	1769	dystrophin. [swissprot;acc:p11532]
	1770	angiomotin. [refseq;acc:nm_133265]
	1771	angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]
	1772	alpha-1-syntrophin (59 kda dystrophin-associated protein a1, acidic component 1) (pro-tgf-alpha cytoplasmic domain-interacting protein 1) (tacip1) (syntrophin 1). [swissprot;acc:q13424]
6218.45	1763	dystrobrevin alpha (dystrobrevin-alpha). [swissprot;acc:q9y4j8]	1.06668	5829.73
6218.77	834	atp synthase alpha chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p25705]	1.10592	5623.18
	835	28s ribosomal protein s18a, mitochondrial precursor (mrp-s18-a) (mrps18a) (mrp-s18-3). [swissprot;acc:q9nvs2]
6220.45	999	triacylglycerol lipase, gastric precursor (ec 3.1.1.3) (gastric lipase) (gl). [swissprot;acc:p07098]	1.095	5680.76
	1000	ba304i5.1 (novel lipase) (fragment). [sptrembl;acc:q96lg2]
	1001	lysosomal acid lipase/cholesteryl ester hydrolase precursor (ec 3.1.1.13) (lal) (acid cholesteryl ester hydrolase) (sterol esterase) (lipase a) (cholesteryl esterase). [swissprot;acc:p38571]
	1002	seryl-trna synthetase, mitochondrial precursor (ec 6.1.1.11) (serine--trna ligase) (serrsmt). [swissprot;acc:q9np81]
	1003	seryl-trna synthetase (ec 6.1.1.11) (serine--trna ligase) (serrs). [swissprot;acc:p49591]
6221.72	1479	hepatocyte nuclear factor 3-alpha (hnf-3a) (forkhead box protein a1). [swissprot;acc:p55317]	1.07511	5787.03
6222.04	560	cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520]	1.13536	5480.24
	561	transforming protein rhoc (h9). [swissprot;acc:p08134]
	562	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]
	563	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]
	564	transforming protein rhoa (h12). [swissprot;acc:p06749]
6223.23	876	peroxisomal carnitine octanoyltransferase (ec 2.3.1.-) (cot). [swissprot;acc:q9ukg9]	1.10249	5644.68
6226.13	1220	cyclin m3; ancient conserved domain protein 3. [refseq;acc:nm_017623]	1.08551	5735.65
6226.23	1222	cyclin m1; ancient conserved domain protein 1. [refseq;acc:nm_020348]		5735.74
6226.46	1219	tcd37 homolog; prune. [refseq;acc:nm_021222]	1.08552	5735.95
6226.52	1218	cyclin m4; ancient conserved domain protein 4. [refseq;acc:nm_020184]		5736
6226.88	1221	cyclin m2; ancient conserved domain protein 2. [refseq;acc:nm_017649]	1.08551	5736.34
6227.33	1789	serine/threonine protein kinase 12 (ec 2.7.1.37) (aurora- and ipl1- like midbody-associated protein 1) (aim-1) (aurora/ipl1-related kinase 2) (aurora-related kinase 2) (stk-1) (aurora-b). [swissprot;acc:q96gd4]	1.06637	5839.72
	1790	kinesin-like protein kif23 (mitotic kinesin-like protein-1) (kinesin- like protein 5). [swissprot;acc:q02241]
	1791	serine/threonine protein kinase 13 (ec 2.7.1.37) (aurora/ipl1/eg2 protein 2) (aurora/ipl1-related kinase 3) (aurora-c). [swissprot;acc:q9uqb9]
	1792	serine/threonine kinase 6 (ec 2.7.1.37) (serine/threonine kinase 15) (aurora/ipl1-related kinase 1) (aurora-related kinase 1) (hark1) (aurora-a) (breast-tumor-amplified kinase). [swissprot;acc:o14965]
	1793	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247]
6230.55	1499	hepatocyte nuclear factor 3-beta (hnf-3b) (forkhead box protein a2). [swissprot;acc:q9y261]	1.07455	5798.31
6232.83	1260	rad54-like protein; rad54 homolog. [refseq;acc:nm_003579]	1.08306	5754.84
6233.12	397	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]	1.16137	5367.04
6233.52	721	syntaxin 7. [swissprot;acc:o15400]	1.11692	5580.97
6236.53	1731	lamin b2. [swissprot;acc:q03252]	1.06776	5840.77
6237.19	2452	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	1.03224	6042.36
6239.55	1569	traf and tnf receptor-associated protein; ets1-associated protein 2. [refseq;acc:nm_016614]	1.0722	5819.37

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.