MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Filtered	description	Interaction Map	Rank	Value Type	green	red	network_comparison	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 1 to 50 of 38536 in total

Filtered  : 0
Network Comparison Type  : Divided

description	Interaction Map	Rank	Value Type	green	red	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	High confidence	37	Measured	934.348	334.401	2.79409
			Squared	1034.13	101.05	10.2338
		53	Rooted	18.0183	11.844	1.5213
		242	Ranked	13895.8	15260.6	1.09822
	Low confidence	131	Measured	851.77	645.504	1.31954
		146	Squared	1268.51	775.72	1.63527
		537	Rooted	17.0804	16.298	1.04801
		629	Ranked	13590.3	13205.3	1.02915
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]		627		10050.9	10347.7	1.02953
		768	Rooted	39.5126	39.0982	1.0106
		778	Measured	4869.42	4825.89	1.00902
		815	Squared	40451	40270.8	1.00447
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	High confidence	19	Measured	26.1599	305.45	11.6763
		26	Squared	0.344399	44.3683	128.828
			Rooted	3.80565	13.7805	3.62106
		47	Ranked	18499.2	12941.7	1.42943
	Low confidence	131	Rooted	9.42485	11.365	1.20585
		171	Measured	181.734	222.779	1.22585
		384	Ranked	14695.2	13533.1	1.08587
		697	Squared	296.481	307.765	1.03806
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	High confidence	316		7355.46	8620.27	1.17196
		370	Rooted	32.0298	30.7424	1.04188
		379	Ranked	10806	11228.4	1.03909
		451	Measured	2642.79	2683.61	1.01545
	Low confidence	763	Squared	6490.54	6603.33	1.01738
		771	Measured	1609.88	1593.68	1.01017
		793	Rooted	23.2445	23.11	1.00582
		825	Ranked	11854.2	11832.8	1.00181
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	High confidence	328	Squared	5878.56	6747.71	1.14785
		458	Rooted	28.5146	28.0847	1.01531
		474	Measured	2263.85	2281.12	1.00763
		495	Ranked	11748.1	11725.2	1.00195
	Low confidence	591	Squared	14694	15800.9	1.07533
		665	Ranked	11538	11801.6	1.02285
		728	Rooted	26.5693	26.1642	1.01548
		785	Measured	2331.31	2349.9	1.00797
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	High confidence	299	Ranked	11512.3	12338.7	1.07178
		438	Rooted	44.9836	43.8864	1.025
		492	Measured	5046.33	5038.33	1.00159
		493	Squared	17901.1	17901.1	1
	Low confidence	453	Ranked	11512.3	12338.7	1.07178
		662	Rooted	44.9836	43.8864	1.025
		822	Measured	5046.33	5038.33	1.00159
		836	Squared	17901.1	17901.1	1
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	High confidence	327	Ranked	10466.5	9897.29	1.05751
		376	Rooted	31.1453	32.3671	1.03923
		438	Measured	2853.65	2925.57	1.0252
		477	Squared	18218.3	18353.1	1.0074
	Low confidence	442	Rooted	25.4539	27.2263	1.06963
		501	Ranked	11352.1	10721.7	1.0588

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.