MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Network Comparison Type	Rank	red	description	Value Type	Interaction Map	Filtered	network_comparison	green

Results: HTML CSV LaTeX

Showing element 501 to 550 of 25824 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	red	description	Value Type	network_comparison	green
126	60.9342	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Rooted	1.23311	75.1387
	94	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Ranked	1.21277	114
	24250	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Measured	1.33499	18164.9
	189976	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	Squared	1.52616	124480
127	60.9353	high-mobility group 20a. [refseq;acc:nm_018200]	Rooted	1.23236	75.094
	94	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Ranked	1.21277	114
	5638.2	transcription factor jun-d. [swissprot;acc:p17535]	Measured	1.33436	7523.39
	88432.6	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]	Squared	1.51365	58423.3
128	48.0515	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	Rooted	1.23069	39.0445
	94	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Ranked	1.21277	114
	4355.61	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Measured	1.3341	5810.82
	87787.3	pnas-18. [sptrembl;acc:q9bzu3]	Squared	1.50952	58155.8
129	54.2343	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	Rooted	1.23044	66.7323
	94	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	Ranked	1.21277	114
	4358.13	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Measured	1.33348	5811.49
	178263	pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	Squared	1.50257	118639
130	55.1026	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Rooted	1.22626	67.5701
	94	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	Ranked	1.21277	114
	2234.68	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Measured	1.33287	2978.53
	148058	44050 protein. [refseq;acc:nm_178832]	Squared	1.4861	99628.4
131	55.1113	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Rooted	1.22577	67.5537
	294.053	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Ranked	1.21228	242.562
	2234.73	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Measured	1.33285	2978.57
	148058	nuclear inhibitor of protein phosphatase-1 (nipp-1) (protein phosphatase 1, regulatory inhibitor subunit 8) [includes: activator of rna decay (ec 3.1.4.-) (ard-1)]. [swissprot;acc:q12972]	Squared	1.4861	99628.4
132	44.963	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Rooted	1.22451	55.0576
	350	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Ranked	1.2069	290
	2236.61	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Measured	1.33253	2980.35
	36359.2	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	Squared	1.48606	24466.8
133	45.4558	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Rooted	1.22316	55.5995
	350	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Ranked	1.2069	290
	1182.25	gbp protein isoform a. [refseq;acc:nm_017870]	Squared	1.46039	1726.55
	23421.5	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Measured	1.33225	17580.4
134	44.849	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	Rooted	1.2218	54.7964
	350	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Ranked	1.2069	290
	21785.2	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Measured	1.32626	16426.1
	81888.8	p66 alpha. [refseq;acc:nm_017660]	Squared	1.45434	56306.5
135	54.935	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	Rooted	1.21253	66.6101
	350	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Ranked	1.2069	290
	21785.2	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Measured	1.32626	16426.1
	81888.8	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	Squared	1.45434	56306.5
136	41.8357	adiponectin receptor 2. [refseq;acc:nm_024551]	Rooted	1.21061	50.6469
	350	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Ranked	1.2069	290
	3620.77	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	Measured	1.31556	4763.34
	81888.8	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	Squared	1.45434	56306.5
137	54.9787	musashi 2 isoform a. [refseq;acc:nm_138962]	Rooted	1.20486	66.2416
	350	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Ranked	1.2069	290
	3620.77	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Measured	1.31556	4763.34
	81606.8	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	Squared	1.45167	56215.8
138	54.9787	musashi 1. [refseq;acc:nm_002442]	Rooted	1.20486	66.2416
	194.372	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Ranked	1.20493	234.204

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.