MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	Network Comparison Type	Value Type	Interaction Map	green	description	network_comparison	red	Filtered

Results: HTML CSV LaTeX

Showing element 1513 to 1562 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	green	description	network_comparison	red
1513	209.509	cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]	1.01794	213.268
1514		protoheme ix farnesyltransferase, mitochondrial precursor (ec 2.5.1.-) (heme o synthase). [swissprot;acc:q12887]
1515	209.511	dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]	1.01793	213.267
1516		dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]
1517		seprase (ec 3.4.21.-) (fibroblast activation protein alpha) (integral membrane serine protease) (170-kda melanoma membrane-bound gelatinase). [swissprot;acc:q12884]
1518	209.524	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (ec 2.7.1.115) (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase). [swissprot;acc:o14874]	1.01783	213.259
1519	240.061	cone-rod homeobox protein. [swissprot;acc:o43186]	1.01779	244.331
1520	240.098	homeobox protein otx1. [swissprot;acc:p32242]	1.01778	244.367
1521	240.212	homeobox protein otx2. [swissprot;acc:p32243]	1.01776	244.478
1522	223.179	mannose-6-phosphate isomerase (ec 5.3.1.8) (phosphomannose isomerase) (pmi) (phosphohexomutase). [swissprot;acc:p34949]	1.01766	219.306
1523		putative ankyrin-repeat containing protein. [refseq;acc:nm_025185]
1524		mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]
1525		protocadherin fat 2 precursor (hfat2) (multiple epidermal growth factor-like domains 1). [swissprot;acc:q9nyq8]
1526		cadherin-related tumor suppressor homolog precursor (fat protein homolog). [swissprot;acc:q14517]
1527		mln64 n-terminal domain homolog (stard3 n-terminal like protein). [swissprot;acc:o95772]
1528	214.021	hepatocyte nuclear factor 3-gamma (hnf-3g) (forkhead box protein a3) (fork head-related protein fkh h3). [swissprot;acc:p55318]	1.01759	217.785
1529	213.031	actin, cytoplasmic 2 (gamma-actin). [swissprot;acc:p02571]	1.01751	216.762
1530	214.98	af-6 protein. [swissprot;acc:p55196]	1.01746	218.733
1531	213.304	cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]	1.01744	217.025
1532	232.376	rna-binding protein 10 (rna binding motif protein 10) (dxs8237e). [swissprot;acc:p98175]	1.01732	228.419
1533		cytochrome c. [swissprot;acc:p00001]
1534		heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]
1535		heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]
1536		fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]
1537		ww domain binding protein 11; npw38-binding protein npwbp; sh3 domain-binding protein snp70. [refseq;acc:nm_016312]
1538		elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]
1539		rna-binding protein 5 (rna binding motif protein 5) (putative tumor suppressor luca15) (g15 protein). [swissprot;acc:p52756]
1540	236.015	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	1.01721	240.077
1541	218.92	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	1.01714	222.672
1542	209.965	trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6]	1.01706	213.546
1543		gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]
1544	216.081	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	1.01704	219.762
1545	216.083	orphan nuclear receptor tr2. [swissprot;acc:p13056]	1.01702	219.76
1546	221.474	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]	1.01701	217.769
1547	218.823	myb-related protein b (b-myb). [swissprot;acc:p10244]	1.01699	222.541
1548	218.802	myb-related protein a (a-myb). [swissprot;acc:p10243]	1.01696	222.512
1549	221.424	dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]	1.01687	225.159
1550		adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]
1551		adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]
1552		adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]
1553	211.833	adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]	1.01679	215.389
1554	193.018	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	1.01656	196.215
1555	192.996	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]		196.192
1556		b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]
1557		zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]
1558	192.977	c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]	1.01655	196.171
1559	192.996	b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]		196.191
1560	170.455	p66 alpha. [refseq;acc:nm_017660]	1.01651	167.687
1561		transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]
1562		tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.