MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	description	Rank	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 601 to 650 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Rank	red	green	network_comparison
clll6 protein. [refseq;acc:nm_020456]	3028	0.00001	0.00001	1
coactosin-like protein. [swissprot;acc:q14019]	1219	211.959	217.258	1.025
coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]	1093	177.432	182.647	1.02939
coatomer beta subunit (beta-coat protein) (beta-cop). [swissprot;acc:p53618]	1036	171.341	176.746	1.03155
coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]	1074	174.387	179.697	1.03045
coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]	1077
coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	1174	187.964	192.849	1.02599
coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]	1075	174.387	179.697	1.03045
coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]	1076
coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]	1079
cofilin, muscle isoform (cofilin 2). [swissprot;acc:q9y281]	2227	217.955	219.336	1.00634
cofilin, non-muscle isoform (18 kda phosphoprotein) (p18). [swissprot;acc:p23528]	2226
collagen alpha 3(iv) chain precursor (goodpasture antigen). [swissprot;acc:q01955]	1989	219.261	217.195	1.00951
collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]	1990	219.26	217.194
collectin sub-family member 12 isoform i; scavenger receptor with c-type lectin; collectin placenta 1; scavenger receptor class a, member 4. [refseq;acc:nm_130386]	2881	0.00001	0.00001	1
colorectal mutant cancer protein (mcc protein). [swissprot;acc:p23508]	1402	209.682	205.329	1.0212
complement component 1, q subcomponent binding protein, mitochondrial precursor (glycoprotein gc1qbp) (gc1q-r protein) (hyaluronan-binding protein 1) (p32) (p33). [swissprot;acc:q07021]	2730	212.922	212.985	1.0003
complement component c6 precursor. [swissprot;acc:p13671]	3199	0.00001	0.00001	1
complement component c7 precursor. [swissprot;acc:p10643]	3064
complement component c8 alpha chain precursor. [swissprot;acc:p07357]	2886
complement component c8 beta chain precursor. [swissprot;acc:p07358]	3207
complement component c9 precursor. [swissprot;acc:p02748]	3057
cone-rod homeobox protein. [swissprot;acc:o43186]	1519	244.331	240.061	1.01779
connective tissue growth factor precursor (hypertrophic chondrocyte- specific protein 24). [swissprot;acc:p29279]	3040	0.00001	0.00001	1
connective tissue growth factor-like protein precursor (ctgf-l) (wnt1 inducible signaling pathway protein 2) (wisp-2) (connective tissue growth factor-related protein 58). [swissprot;acc:o76076]	3188
conserved oligomeric golgi complex component 1. [swissprot;acc:q8wtw3]	2836
conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]	1213	214.364	219.759	1.02517
conserved oligomeric golgi complex component 3 (vesicle docking protein sec34 homolog) (p94). [swissprot;acc:q96jb2]	2627	224.891	225.195	1.00135
conserved oligomeric golgi complex component 6. [swissprot;acc:q9y2v7]	2110	211.099	209.607	1.00712
conserved oligomeric golgi complex component 7. [swissprot;acc:p83436]	2750	190.522	190.496	1.00014
conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	493	220.172	235.98	1.0718
cop-coated vesicle membrane protein p24 precursor (p24a). [swissprot;acc:q15363]	3168	0.00001	0.00001	1
cop9 complex subunit 4; likely ortholog of mouse cop9 (constitutive photomorphogenic), subunit 4 (arabidopsis); cop9 (constitutive photomorphogenic, arabidopsis, homolog) subunit 4. [refseq;acc:nm_016129]	1500	213.398	209.52	1.01851
cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	175	199.949	234.187	1.17123
cop9 constitutive photomorphogenic homolog subunit 5; jun activation domain-binding protein. [refseq;acc:nm_006837]	2380	212.724	213.574	1.004
cop9 signalosome complex subunit 1 (g protein pathway suppressor 1) (gps1 protein) (mfh protein). [swissprot;acc:q13098]	2827	0.00001	0.00001	1
cop9 signalosome complex subunit 2 (signalosome subunit 2) (sgn2) (thyroid receptor interacting protein 15) (trip15). [swissprot;acc:q15647]	2841
cop9 subunit 6 (mov34 homolog, 34 kd). [refseq;acc:nm_006833]	2374	212.724	213.574	1.004
copper-transporting atpase 1 (ec 3.6.3.4) (copper pump 1) (menkes disease-associated protein). [swissprot;acc:q04656]	2352	215.088	214.155	1.00436
copper-transporting atpase 2 (ec 3.6.3.4) (copper pump 2) (wilson disease-associated protein). [swissprot;acc:p35670]	2354	215.078	214.148	1.00434
coproporphyrinogen iii oxidase, mitochondrial precursor (ec 1.3.3.3) (coproporphyrinogenase) (coprogen oxidase) (cox). [swissprot;acc:p36551]	2617	202.821	202.54	1.00139
core-binding factor, beta subunit (cbf-beta) (polyomavirus enhancer binding protein 2 beta subunit) (pebp2-beta) (pea2-beta) (sl3-3 enhancer factor 1 beta subunit) (sl3/akv core-binding factor beta subunit). [swissprot;acc:q13951]	3183	0.00001	0.00001	1
cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]	1513	213.268	209.509	1.01794
cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	1168	219.399	213.784	1.02626
cpz gene product. [refseq;acc:nm_003652]	716	223.121	211.685	1.05402
creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277]	1940	198.19	196.252	1.00988
creatine kinase, m chain (ec 2.7.3.2) (m-ck). [swissprot;acc:p06732]	1971	198.258	196.346	1.00974
creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540]	1936	198.3	196.347	1.00995
creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	1938	198.293	196.341	1.00994
crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	284	224.657	203.235	1.10541

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.