Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Rank Gene description Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1608 to 1657 of 29840 in total
Value Type  : Measured
Interaction Map  : High confidence
Rank
description
Network Comparison Type
Filtered
red
green
network_comparison
402 myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882] Divided 0 548.5 527.5 1.03981
403 fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322] 1 5201.41 4479.76 1.16109
maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708] Subtracted 0 2290.09 2264.37 25.72
myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3] Divided 548.5 527.5 1.03981
ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385] Subtracted 1 6259.3 7190.91 931.61
404 importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060] 7802.31 8731.82 929.51
leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71] Divided 5201.41 4479.76 1.16109
spir-2 protein (fragment). [sptrembl;acc:q8wwl2] Subtracted 0 31.1429 56.278 25.1351
thymidylate kinase (ec 2.7.4.9) (dtmp kinase). [swissprot;acc:p23919] Divided 1229.57 1278.36 1.03968
405 guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992] Subtracted 1 1836.71 907.546 929.164
integral membrane protein cii-3b. [sptrembl;acc:o75609] Divided 0 2218.63 2304.22 1.03858
laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047] 1 5201.41 4479.76 1.16109
similar to cg7020 gene product (fragment). [sptrembl;acc:q96ib4] Subtracted 0 2806.38 2782.56 23.82
406 dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0] 1915.69 1892.44 23.25
guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148] 1 1836.71 907.564 929.146
thymic stromal co-transporter. [refseq;acc:nm_033051] Divided 5201.41 4479.76 1.16109
u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695] 0 2363.32 2454.04 1.03839
407 guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086] Subtracted 1 1836.76 907.741 929.019
hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712] Divided 0 3614.24 3481.87 1.03802
transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884] Subtracted 44 21 23
wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516] Divided 1 6603.41 7664.65 1.16071
408 dok-like protein. [refseq;acc:nm_024872] 6102.59 7081.46 1.1604
glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409] 0 219.031 227.143 1.03704
guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488] Subtracted 1 1836.76 907.763 928.997
zinc finger protein 232. [swissprot;acc:q9uny5] 0 721.814 699.215 22.599
409 docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496] Divided 1 6102.59 7081.46 1.1604
glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189] 0 219.19 227.308 1.03704
guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087] Subtracted 1 1836.76 907.774 928.986
zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028] 0 721.888 699.297 22.591
410 autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0] 1 6744.05 5815.13 928.92
docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704] Divided 6102.59 7081.46 1.1604
glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410] 0 218.71 226.81 1.03704
zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58] Subtracted 721.913 699.324 22.589
411 guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899] 1 1836.8 907.903 928.897
transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). [swissprot;acc:o00268] Divided 0 31122 30022.4 1.03663
tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685] 1 6102.59 7081.46 1.1604
zinc finger imprinted 2. [swissprot;acc:q9nzv7] Subtracted 0 722.144 699.577 22.567
412 60s ribosomal protein l39. [swissprot;acc:p02404] Divided 3024.78 2923.92 1.03449
alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298] Subtracted 1527.36 1504.85 22.51
guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898] 1 1836.81 907.978 928.832
mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390] Divided 3594.31 4169.95 1.16015
413 guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754] Subtracted 1836.81 907.978 928.832
lifeguard; kiaa0950 protein. [refseq;acc:nm_012306] Divided 0 613.385 634.192 1.03392
proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931] Subtracted 39.7924 62.2106 22.4182
vav proto-oncogene. [swissprot;acc:p15498] Divided 1 6644.99 7707.8 1.15994
414 autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0] 6744.05 5815.13 1.15974
pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669] Subtracted 5051.16 5975.51 924.35
ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921] Divided 0 7520.78 7276.12 1.03363
transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193] Subtracted 125.5 103.5 22
415 j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330] 1 7725.1 8647.74 922.64

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/