MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	description	Network Comparison Type	Rank	Interaction Map	Value Type	red	green	network_comparison	Filtered

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	red	green	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Divided	18	Ranked	185.678	245.247	1.32082
		60	Measured	4489.19	2765.82	1.6231
		64	Rooted	63.8686	47.2654	1.35128
		245	Squared	8875.01	6768.05	1.31131
	Subtracted	54	Ranked	185.678	245.247	59.569
		67	Rooted	63.8686	47.2654	16.6032
		164	Measured	4489.19	2765.82	1723.37
		1962	Squared	8875.01	6768.05	2106.96
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Divided	295		30807.7	39351.7	1.27733
		509	Measured	7551.8	8630.06	1.14278
		805	Rooted	74.3557	79.1513	1.0645
		1038	Ranked	186.741	181.041	1.03148
	Subtracted	274	Squared	30807.7	39351.7	8544
		310	Measured	7551.8	8630.06	1078.26
		610	Rooted	74.3557	79.1513	4.7956
		1120	Ranked	186.741	181.041	5.7
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Divided	294	Squared	30826.5	39383.9	1.2776
		508	Measured	7556.75	8636.87	1.14293
		804	Rooted	74.3877	79.1931	1.0646
		1032	Ranked	186.664	180.943	1.03162
	Subtracted	273	Squared	30826.5	39383.9	8557.4
		307	Measured	7556.75	8636.87	1080.12
		609	Rooted	74.3877	79.1931	4.8054
		1115	Ranked	186.664	180.943	5.721
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Divided	311	Squared	30566.4	38866.5	1.27154
		514	Measured	7477	8532.02	1.1411
		822	Rooted	73.8577	78.5795	1.06393
		1048	Ranked	187.96	182.308	1.031
	Subtracted	280	Squared	30566.4	38866.5	8300.1
		319	Measured	7477	8532.02	1055.02
		631	Rooted	73.8577	78.5795	4.7218
		1128	Ranked	187.96	182.308	5.652
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Divided	308	Squared	30596.2	38919.9	1.27205
		513	Measured	7485.08	8543.66	1.14143
		811	Rooted	73.9102	78.6514	1.06415
		1043	Ranked	187.834	182.137	1.03128
	Subtracted	279	Squared	30596.2	38919.9	8323.7
		318	Measured	7485.08	8543.66	1058.58
		616	Rooted	73.9102	78.6514	4.7412
		1121	Ranked	187.834	182.137	5.697
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Divided	3126	Measured	0.00001	0.00001	1
			Ranked
			Squared
			Rooted
	Subtracted		Measured	0	0	0
			Ranked
			Squared
			Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	Divided	588	Squared	23526.4	27879.3	1.18502
		1136	Measured	5790.65	6303.92	1.08864

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.