Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Hugo Rank Network Comparison Type Gene network_comparison red Interaction Map description Filtered green
Results: HTML CSV LaTeX Showing element 1 to 50 of 3228 in total
Value Type  : Ranked
Hugo  : no value
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
network_comparison
red
description
green
2 1.86667 15 mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 28
30 1.29991 187.457 serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007] 243.678
41 1.27273 322 protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949] 253
43 1.2714 204.641 jun dimerization protein. [refseq;acc:nm_130469] 160.957
56 1.25998 266.856 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262] 336.233
63 1.25973 266.865 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] 336.178
85 1.24949 88.2482 melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 110.265
88 hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]
94 melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
99 melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]
147 1.2009 50.7983 nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] 42.3003
149 1.19718 142 atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915] 170
152 1.19565 55 myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] 46
168 1.18722 82.5916 gaba-a receptor-associated protein. [sptrembl;acc:q9by60] 98.0548
178 1.1652 226.887 formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892] 194.72
179 1.16476 226.884 huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404] 194.79
191 1.14179 226.582 filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] 198.444
215 1.125 112 myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533] 126
221 myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]
238 1.11785 227.357 rd protein. [swissprot;acc:p18615] 254.15
247 1.11719 237.302 rna-binding protein. [refseq;acc:nm_019027] 212.41
248 apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]
271 1.10763 241.373 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340] 267.352
277 1.10665 241.849 40s ribosomal protein s29. [swissprot;acc:p30054] 267.642
281 1.10557 241.808 60s ribosomal protein l17 (l23). [swissprot;acc:p18621] 267.335
288 1.10517 240.758 40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750] 266.078
289 1.10486 272.781 hpaii tiny fragments locus 9c. [refseq;acc:nm_022727] 246.892
293 1.10356 240.782 60s ribosomal protein l23 (l17). [swissprot;acc:p23131] 265.717
297 1.1029 235.727 60s ribosomal protein l7. [swissprot;acc:p18124] 259.984
304 1.1017 242.339 40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174] 266.986
306 1.10126 242.153 60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] 266.673
317 1.09998 224.445 splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393] 204.044
321 1.09949 241.892 c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02] 265.959
323 1.09947 241.884 60s ribosomal protein l23a. [swissprot;acc:p29316] 265.945
337 1.0983 243.583 60s ribosomal protein l12. [swissprot;acc:p30050] 267.527
338 60s ribosomal protein l12 like protein. [sptrembl;acc:o60886] 267.528
339 dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02] 267.527
341 1.09805 240.243 60s ribosomal protein l9. [swissprot;acc:p32969] 263.798
344 1.0973 241.625 40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880] 265.136
348 1.09728 242.14 adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144] 265.696
356 1.09684 243.24 60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025] 266.796
357 1.09683 243.12 60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635] 266.661
372 1.09447 186.52 ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464] 170.42
380 1.09368 242.109 suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169] 264.79
387 1.09029 242.238 40s ribosomal protein s18 (ke-3) (ke3). [swissprot;acc:p25232] 264.11
388 1.09015 227.575 small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578] 208.756
396 1.08945 240.801 putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642] 262.34
406 1.08731 265.634 transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186] 244.304
410 1.0864 233.376 tfiih basal transcription factor complex p44 subunit (basic transcription factor 2 44 kda subunit) (btf2-p44) (general transcription factor iih polypeptide 2). [swissprot;acc:q13888] 253.539
452 1.07784 224.161 ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36] 207.972

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/