Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Filtered Rank green Interaction Map network_comparison Value Type description red Network Comparison Type
Results: HTML CSV LaTeX Showing element 501 to 550 of 38536 in total
Filtered  : 0
Network Comparison Type  : Divided
Rank
green
Interaction Map
network_comparison
Value Type
description
red
63 75.6508 Low confidence 2.03842 Measured laminin beta-1 chain precursor (laminin b1 chain). [swissprot;acc:p07942] 154.208
173.307 3.92038 Squared synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] 44.2067
11453 High confidence 1.34428 Ranked oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977] 8519.83
15783.5 Low confidence 1.27551 60s ribosomal protein l37a. [swissprot;acc:p12751] 12374.3
64 15.2519 High confidence 3.33542 Squared tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677] 50.8715
18 1800000 Measured phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750] 0.00001
22.5496 1.43422 Rooted muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446] 15.7225
23.6984 Low confidence 2.03615 Measured dna helicase homolog (fragment). [sptrembl;acc:q9y645] 48.2534
66 1.44645 Rooted anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801] 45.6289
173.244 3.88974 Squared sedlin. [swissprot;acc:o14582] 44.5387
11356 1.2736 Ranked selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611] 14463
20387 High confidence 1.33563 similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517] 15264
65 0.00001 1800000 Measured rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372] 18
10.4958 Low confidence 1.43105 Rooted transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193] 7.33436
15.1833 High confidence 3.33538 Squared 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643] 50.642
29.2291 1.42072 Rooted 60s ribosomal protein l21. [swissprot;acc:p46778] 20.5734
47.3595 Low confidence 3.55848 Squared l-lactate dehydrogenase a chain (ec 1.1.1.27) (ldh-a) (ldh muscle subunit) (ldh-m). [swissprot;acc:p00338] 13.3089
923.065 1.98228 Measured bet5 homolog (multiple myeloma protein 2) (mum-2). [swissprot;acc:q9y5r8] 465.658
10406.3 High confidence 1.32502 Ranked e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409] 7853.67
12943.5 Low confidence 1.27245 alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7] 10172.1
66 21.9983 High confidence 1.40854 Rooted oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977] 30.9855
26.828 Low confidence 1.4185 elongation of very long chain fatty acids protein 2. [swissprot;acc:q9nxb9] 18.9129
127.516 3.47056 Squared nadh-ubiquinone oxidoreductase mlrq subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-mlrq) (ci-mlrq). [swissprot;acc:o00483] 36.7422
142.981 1.89874 Measured tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677] 271.484
385.626 High confidence 1.78524 soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825] 688.436
558.241 3.2204 Squared dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2] 1797.76
10030.4 Low confidence 1.26584 Ranked kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8] 7923.89
15180 High confidence 1.32449 heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174] 11461
67 12.9538 Low confidence 1.41698 Rooted alpha 2 globin. [refseq;acc:nm_000517] 18.3553
15.2519 3.33542 Squared tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677] 50.8715
15.3166 High confidence 1.39177 Rooted isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252] 11.0051
142.417 Low confidence 1.89769 Measured 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643] 270.264
190.865 High confidence 3.1865 Squared filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] 608.191
898 1.78508 Measured 1603
14291.5 1.32408 Ranked presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341] 10793.5
14697.6 Low confidence 1.26309 dynamin-like 120 kda protein, mitochondrial precursor (optic atrophy 1 gene protein). [swissprot;acc:o60313] 11636.2
68 0.00001 High confidence 3136000 Squared mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3] 31.36
8.63381 1.38766 Rooted alpha crystallin a chain. [swissprot;acc:p02489] 6.22183
12.9627 Low confidence 1.41651 hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096] 18.3618
15.1833 3.33538 Squared 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643] 50.642
351.772 High confidence 1.76802 Measured protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981] 198.964
734 Low confidence 1.86294 nadh-ubiquinone oxidoreductase mlrq subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-mlrq) (ci-mlrq). [swissprot;acc:o00483] 394
9824.6 1.25899 Ranked repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273] 7803.58
11823.3 High confidence 1.32362 purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [swissprot;acc:p00491] 8932.56
69 12.9659 Low confidence 1.41635 Rooted myoglobin. [swissprot;acc:p02144] 18.3642
13.5207 High confidence 1.38596 cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747] 18.7392
50.7408 3.12432 Squared protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981] 16.2406
70.5 Low confidence 1.82979 Measured tubulointerstitial nephritis antigen. [refseq;acc:nm_014464] 129
253.857 3.26573 Squared tolloid-like 1. [refseq;acc:nm_012464] 77.7335
2804 High confidence 1.7602 Measured dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0] 1593

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/