MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Network Comparison Type	Gene	description	Rank	Filtered	Interaction Map	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 268 to 317 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

description	Rank	red	network_comparison	green
aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	1420	203.979	1.02084	208.229
aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763]	2064	207.655	1.00833	205.939
aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [swissprot;acc:p48728]	2544	212.67	1.00192	212.262
ammecr1 protein. [refseq;acc:nm_015365]	1577	222.585	1.01645	218.982
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	52	133	1.26667	105
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	139	271.752	1.20415	225.68
amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	2490	194.527	1.00284	195.08
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	3191	0.00001	1	0.00001
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	2636	195.635	1.00128	195.384
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	2663	204.768	1.00107	204.549
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	2679	190.142	1.00096	189.959
androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	240	227.357	1.11785	254.15
angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]	2586	213.422	1.00154	213.75
angiomotin. [refseq;acc:nm_133265]	2585
anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	143	59	1.20408	49
ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [swissprot;acc:q01484]	2519	215.835	1.00234	216.341
ankyrin 3 (ank-3) (ankyrin g). [swissprot;acc:q12955]	2518
ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	805	212.386	1.04425	221.785
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	1088	219.673	1.0295	213.378
annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	1094	219.655	1.02938	213.385
antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]	2418	218.2	1.00359	218.984
apg3p; pc3-96 protein. [refseq;acc:nm_022488]	169	82.5916	1.18722	98.0548
apical-like protein (apxl protein). [swissprot;acc:q13796]	362	231.492	1.09641	211.136
apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	248	237.302	1.11719	212.41
apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	1606	207.916	1.0159	204.662
apolipoprotein b-100 precursor (apo b-100) [contains: apolipoprotein b-48 (apo b-48)]. [swissprot;acc:p04114]	2151	217.871	1.00686	219.366
apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	1293	233.942	1.024	228.46
apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	1014	243.045	1.03238	235.422
apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	1132	218.484	1.02731	212.675
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	1111	217.99	1.02766	212.123
apoptosis-inducing factor (aif)-homologous mitochondrion-associated inducer of death; p53-responsive gene 3. [refseq;acc:nm_032797]	2421	210.205	1.00359	209.454
apurinic/apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; apex nuclease-like 2. [refseq;acc:nm_014481]	2531	216.264	1.00221	215.787
aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	2690	188.191	1.00077	188.046
aquaporin 5. [swissprot;acc:p55064]	2692	188.192		188.048
aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	2691	188.193
aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972]	2694	188.223	1.00075	188.081
arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	1184	216.729	1.02586	222.334
arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	1110	216.78	1.02769	222.782
arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	947	212.51	1.03567	205.191
arginase 1 (ec 3.5.3.1) (liver-type arginase). [swissprot;acc:p05089]	1885	204.44	1.01064	206.615
arginase ii, mitochondrial precursor (ec 3.5.3.1) (non-hepatic arginase) (kidney-type arginase). [swissprot;acc:p78540]	1886	204.512	1.01061	206.682
arginine-glutamic acid dipeptide (re) repeats; atrophin 1-like; arginine glutamic acid dipeptide re repeats. [refseq;acc:nm_012102]	1379	218.47	1.02148	213.875
arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]	1478	215.122	1.01922	211.066
argininosuccinate lyase (ec 4.3.2.1) (arginosuccinase) (asal). [swissprot;acc:p04424]	2108	216.36	1.00726	217.93
argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]	1546	217.769	1.01701	221.474
arginyl-trna synthetase-like; arginine-trna ligase. [refseq;acc:nm_020320]	2235	200.95	1.0062	199.711
ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	2798	0.00001	1	0.00001
armet protein precursor (arginine-rich protein). [swissprot;acc:p55145]	1714	206.549	1.01327	203.844
arp2/3 complex 16 kda subunit (p16-arc) (actin-related protein 2/3 complex subunit 5). [swissprot;acc:o15511]	2602	224.875	1.00141	225.192
arp2/3 complex 21 kda subunit (p21-arc) (actin-related protein 2/3 complex subunit 3). [swissprot;acc:o15145]	2632	224.891	1.00135	225.195

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.