Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene Rank description Network Comparison Type Value Type Interaction Map Filtered red network_comparison green

Results: HTML CSV LaTeX

Showing element 101 to 150 of 9634 in total

Network Comparison Type

: Divided
Value Type

: Measured

Rank	description	Interaction Map	Filtered	red	network_comparison	green
26	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	High confidence	0	153	4.3268	662
	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Low confidence	0	143	3.04255	47
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	High confidence	1	1833.01	2.0534	892.67
	sperm associated antigen 7. [refseq;acc:nm_004890]	Low confidence		23318	1.20939	19280.8
27	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	High confidence		1834.33	2.04922	895.134
	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Low confidence	0	105.5	2.97183	35.5
	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	High confidence	0	570	4.10072	139
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Low confidence	1	3840.85	1.20152	4614.87
28	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	High confidence	0	570	4.10072	139
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	High confidence	1	1834.36	2.04912	895.194
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Low confidence	0	105.5	2.97183	35.5
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Low confidence	1	3098.94	1.2003	3719.66
29	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	High confidence	1	1834.52	2.04858	895.507
	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Low confidence	0	105.5	2.97183	35.5
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	High confidence	0	111.278	3.90833	434.911
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Low confidence	1	3121.28	1.19818	3739.84
30	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Low confidence	1	36474.3	1.19288	43509.4
	dystrophin. [swissprot;acc:p11532]	High confidence	0	427.217	3.82335	111.739
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	High confidence	1	1834.59	2.04837	895.633
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Low confidence	0	105.5	2.97183	35.5
31	dok-like protein. [refseq;acc:nm_024872]	High confidence	0	35	3500000	0.00001
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	High confidence	1	1834.63	2.04827	895.697
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Low confidence	0	105.5	2.97183	35.5
	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Low confidence	1	36469.3	1.19287	43503.3
32	cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	High confidence	0	598	3.25	184
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	High confidence	1	1834.73	2.04793	895.893
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Low confidence	0	105.5	2.97183	35.5
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Low confidence	1	36360.3	1.19275	43368.8
33	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	High confidence	1	1835.3	2.04611	896.972
	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	High confidence	0	12.6208	3.15402	39.8063
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Low confidence	0	105.5	2.97183	35.5
	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	Low confidence	1	36360.3	1.19275	43368.8
34	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	High confidence	0	143	3.04255	47
	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	High confidence	1	1836.71	2.02382	907.546
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Low confidence	0	105.5	2.97183	35.5
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Low confidence	1	5339.5	1.1897	6352.4
35	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	High confidence	0	459.5	2.99674	1377
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Low confidence	1	33111.4	1.18866	39358.1
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	High confidence	1	1836.71	2.02378	907.564
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Low confidence	0	105.5	2.97183	35.5
36	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	High confidence	1	1836.76	2.02344	907.741
	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	High confidence	0	157	2.80357	56
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Low confidence	0	105.5	2.97183	35.5
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Low confidence	1	6462.09	1.17513	7593.77
37	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	High confidence	0	334.401	2.79409	934.348
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	High confidence	1	1836.76	2.02339	907.763
	jun dimerization protein. [refseq;acc:nm_130469]	Low confidence	1	6462.09	1.17513	7593.77
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Low confidence	0	105.5	2.97183	35.5
38	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	High confidence	1	1836.76	2.02337	907.774
38	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Low confidence	0	105.5	2.97183	35.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/