MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	description	green	Filtered	Interaction Map	network_comparison	red	Gene	Rank	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 51 to 100 of 77072 in total

Value Type  : Measured

description	green	Filtered	Interaction Map	network_comparison	red	Rank	Network Comparison Type
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	8956.98	1	Low confidence	1.04562	8566.17	591	Divided
				390.81		498	Subtracted
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	6788.96		High confidence	1.07145	6336.22	1600	Divided
				452.74		1404	Subtracted
	8288.57		Low confidence	1.03829	7982.87	993	Divided
				305.7		997	Subtracted
15 kda selenoprotein precursor. [swissprot;acc:o60613]	6933.36		High confidence	1.09283	6344.41	1043	Divided
				588.95		865	Subtracted
	8083.96		Low confidence	1.02563	7881.96	3577	Divided
				202		3582	Subtracted
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	0		High confidence	0	0	2855
	0.00001			1	0.00001		Divided
	8425.81		Low confidence	1.03184	8165.8	2067
				260.01		1863	Subtracted
16.7kd protein. [refseq;acc:nm_016139]	8483.17			1.02235	8297.71	4005	Divided
				185.46		3907	Subtracted
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	6113.96		High confidence	1.02511	5964.17	2521	Divided
				149.79		2496	Subtracted
	8498.04		Low confidence	1.0377	8189.31	1051	Divided
				308.73		975	Subtracted
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	4869.42	0		1.00902	4825.89	778	Divided
				43.53		627	Subtracted
	8689.28	1		1.04487	8316.12	631	Divided
				373.16		562	Subtracted
2,4-dienoyl coa reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-coa reductase. [refseq;acc:nm_020664]	8354			1.01654	8218.07	4609	Divided
				135.93		4587	Subtracted
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor (ec 2.4.1.45) (udp-galactose-ceramide galactosyltransferase) (ceramide udp-galactosyltransferase) (cerebroside synthase). [swissprot;acc:q16880]	7708.55			1.03048	7480.51	2443	Divided
				228.04		2870	Subtracted
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	6192.72		High confidence	1.07824	5743.36	1393	Divided
				449.36		1426	Subtracted
	7938.52		Low confidence	1.03229	7690.22	1973	Divided
				248.3		2251	Subtracted
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	6362.25		High confidence	1.0261	6200.39	2506	Divided
				161.86		2455	Subtracted
	8332.97		Low confidence	1.03784	8029.13	1032	Divided
				303.84		1019	Subtracted
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	6957.34		High confidence	1.03268	6737.15	2451	Divided
				220.19		2344	Subtracted
	8054.46		Low confidence	1.02623	7848.62	3458	Divided
				205.84		3506	Subtracted
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	6048.94		High confidence	1.04585	5783.76	2288	Divided
				265.18		2239	Subtracted
	8033.99		Low confidence	1.02067	7871.26	4165	Divided
				162.73		4352	Subtracted
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	5843.51		High confidence	1.36977	4266.04	107	Divided
				1577.47		179	Subtracted
	8143.47		Low confidence	1.06489	7647.22	234	Divided
				496.25		269	Subtracted
25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811]	8007.43			1.04033	7697.01	863	Divided
				310.42		951	Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.