MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Hugo	Rank	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 601 to 650 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Hugo	Rank	description	green	red	network_comparison
BRD1	3139	bromodomain-containing protein 1 (br140-like protein). [swissprot;acc:o95696]	0.00001	0.00001	1
BRD2	2241	bromodomain-containing protein 2 (ring3 protein) (o27.1.1). [swissprot;acc:p25440]	224.338	222.96	1.00618
BRD3	2237	bromodomain-containing protein 3 (ring3-like protein). [swissprot;acc:q15059]	224.343	222.965
BRD4	2238	bromodomain-containing protein 4 (hunk1 protein). [swissprot;acc:o60885]	224.337	222.959
BRD7	2747	bromodomain containing 7; bromodomain protein; bromodomain-containing 7. [refseq;acc:nm_013263]	201.514	201.477	1.00018
BRDT	2239	testis-specific bromodomain protein. [refseq;acc:nm_001726]	224.336	222.958	1.00618
BRF1	478	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994]	212.321	228.051	1.07409
BRP44	742	brain protein 44. [swissprot;acc:o95563]	120.078	126.215	1.05111
BRPF1	2543	tubulin tyrosine ligase-like protein hottl (hqp0207). [swissprot;acc:q9y4r7]	225.164	224.726	1.00195
BRPF3	3149	bromodomain and phd finger-containing protein 3 (fragment). [swissprot;acc:q9uld4]	0.00001	0.00001	1
BTAF1	2595	tbp-associated factor 172 (taf-172) (taf(ii)170). [swissprot;acc:o14981]	219.696	220.02	1.00147
BTBD14B	2872	transcriptional repressor nac1. [refseq;acc:nm_052876]	0.00001	0.00001	1
BTF3	865	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	203.814	211.961	1.03997
BUB1B	1707	mitotic checkpoint serine/threonine-protein kinase bub1 beta (ec 2.7.1.-) (hbubr1) (mad3/bub1-related protein kinase) (mitotic checkpoint kinase mad3l). [swissprot;acc:o60566]	218.334	221.283	1.01351
BUB3	1632	mitotic checkpoint protein bub3. [swissprot;acc:o43684]	218.658	221.934	1.01498
BYSL	1149	bystin. [swissprot;acc:q13895]	233.185	239.505	1.0271
C10orf118	2846	ctcl tumor antigen l14-2. [refseq;acc:nm_018017]	0.00001	0.00001	1
C10orf137	3095	erythroid differentiation-related factor 1. [refseq;acc:nm_015608]
C10orf83	2506	44050 protein. [refseq;acc:nm_178832]	151.009	151.386	1.0025
C11orf2	1211	chromosome 11 open reading frame2; chromosome 11 open reading frame2. [refseq;acc:nm_013265]	219.759	214.364	1.02517
C13orf1	3028	clll6 protein. [refseq;acc:nm_020456]	0.00001	0.00001	1
C14orf122	1819	protein c14orf122 (cgi-112). [swissprot;acc:q9y3b6]	217.926	220.462	1.01164
C14orf124	3138	hcdi protein. [refseq;acc:nm_020195]	0.00001	0.00001	1
C15orf15	1998	ribosomal protein l24-like; 60s ribosomal protein l30 isolog; my024 protein; homolog of yeast ribosomal like protein 24. [refseq;acc:nm_016304]	198.37	200.219	1.00932
C16orf35	644	cgthba protein (-14 gene protein). [swissprot;acc:q12980]	230.596	217.67	1.05938
C16orf42	1506	c316g12.2 (novel protein similar to predicted yeast, worm and archae- bacterial proteins) (similar to und313) (s. cervisiae) (hypothetical protein). [sptrembl;acc:q9ujk0]	208.339	212.103	1.01807
C16orf70	2417	upf0183 protein. [swissprot;acc:q9bsu1]	218.984	218.2	1.00359
C16orf80	823	transcription factor iib. [refseq;acc:nm_013242]	197.471	206.068	1.04354
C19orf2	2371	rna polymerase ii subunit 5-mediating protein (rpb5-mediating protein). [swissprot;acc:o94763]	219.434	218.555	1.00402
C19orf29	2045	ny-ren-24 antigen (fragment). [sptrembl;acc:q9y5a4]	198.24	199.928	1.00851
C19orf56	3102	protein cgi-140 (protein ptd008) (my006 protein). [swissprot;acc:q9y284]	0.00001	0.00001	1
C1orf179	1782	hyporthetical protein mgc27169. [refseq;acc:nm_176782]	203.874	206.332	1.01206
C1QBP	2730	complement component 1, q subcomponent binding protein, mitochondrial precursor (glycoprotein gc1qbp) (gc1q-r protein) (hyaluronan-binding protein 1) (p32) (p33). [swissprot;acc:q07021]	212.985	212.922	1.0003
C20orf118	2060	dj132f21.2 (contains a novel protein similar to the l82e from drosophila) (fragment). [sptrembl;acc:q9h125]	216.981	218.79	1.00834
C20orf24	3131	protein c20orf24 (rab5-interacting protein) (rip5) (pnas-11). [swissprot;acc:q9buv8]	0.00001	0.00001	1
C20orf3	813	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	221.785	212.386	1.04425
C20orf4	1587	protein c20orf4 (protein cgi-23) (pro0225). [swissprot;acc:q9y312]	216.598	220.129	1.0163
C20orf43	3206	protein c20orf43 (hspc164/hspc169) (ad-007) (cda05). [swissprot;acc:q9by42]	0.00001	0.00001	1
C21orf2	2874	protein c21orf2 (c21orf-humf09g8.5) (yf5/a2). [swissprot;acc:o43822]
C21orf55	1942	j domain protein c21orf55. [swissprot;acc:q9nx36]	196.319	198.257	1.00987
C21orf66	2539	gc-rich sequence dna-binding factor homolog. [swissprot;acc:q9y5b6]	216.699	217.144	1.00205
C3orf37	2774	dc12 protein. [refseq;acc:nm_020187]	0.00001	0.00001	1
C3orf60	803	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]	221.785	212.386	1.04425
C6	3199	complement component c6 precursor. [swissprot;acc:p13671]	0.00001	0.00001	1
C6orf35	3030	uncharacterized bone marrow protein bm033. [refseq;acc:nm_018452]
C7	3064	complement component c7 precursor. [swissprot;acc:p10643]
C8A	2886	complement component c8 alpha chain precursor. [swissprot;acc:p07357]
C8B	3207	complement component c8 beta chain precursor. [swissprot;acc:p07358]
C9	3057	complement component c9 precursor. [swissprot;acc:p02748]
CAB39	2976	mo25 protein (cgi-66). [swissprot;acc:q9y376]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.