MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	Gene	description	Value Type	Rank	Network Comparison Type	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 38536 in total

Filtered  : 0
Network Comparison Type  : Divided

description	Value Type	Rank	Interaction Map	red	green	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Measured	37	High confidence	334.401	934.348	2.79409
		131	Low confidence	645.504	851.77	1.31954
	Ranked	242	High confidence	15260.6	13895.8	1.09822
		629	Low confidence	13205.3	13590.3	1.02915
	Squared	37	High confidence	101.05	1034.13	10.2338
		146	Low confidence	775.72	1268.51	1.63527
	Rooted	53	High confidence	11.844	18.0183	1.5213
		537	Low confidence	16.298	17.0804	1.04801
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	Measured	778		4825.89	4869.42	1.00902
	Ranked	627		10347.7	10050.9	1.02953
	Squared	815		40270.8	40451	1.00447
	Rooted	768		39.0982	39.5126	1.0106
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Measured	19	High confidence	305.45	26.1599	11.6763
		171	Low confidence	222.779	181.734	1.22585
	Ranked	47	High confidence	12941.7	18499.2	1.42943
		384	Low confidence	13533.1	14695.2	1.08587
	Squared	26	High confidence	44.3683	0.344399	128.828
		697	Low confidence	307.765	296.481	1.03806
	Rooted	26	High confidence	13.7805	3.80565	3.62106
		131	Low confidence	11.365	9.42485	1.20585
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	Measured	451	High confidence	2683.61	2642.79	1.01545
		771	Low confidence	1593.68	1609.88	1.01017
	Ranked	379	High confidence	11228.4	10806	1.03909
		825	Low confidence	11832.8	11854.2	1.00181
	Squared	316	High confidence	8620.27	7355.46	1.17196
		763	Low confidence	6603.33	6490.54	1.01738
	Rooted	370	High confidence	30.7424	32.0298	1.04188
		793	Low confidence	23.11	23.2445	1.00582
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	Measured	474	High confidence	2281.12	2263.85	1.00763
		785	Low confidence	2349.9	2331.31	1.00797
	Ranked	495	High confidence	11725.2	11748.1	1.00195
		665	Low confidence	11801.6	11538	1.02285
	Squared	328	High confidence	6747.71	5878.56	1.14785
		591	Low confidence	15800.9	14694	1.07533
	Rooted	458	High confidence	28.0847	28.5146	1.01531
		728	Low confidence	26.1642	26.5693	1.01548
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	Measured	492	High confidence	5038.33	5046.33	1.00159
		822	Low confidence
	Ranked	299	High confidence	12338.7	11512.3	1.07178
		453	Low confidence
	Squared	493	High confidence	17901.1	17901.1	1
		836	Low confidence
	Rooted	438	High confidence	43.8864	44.9836	1.025
		662	Low confidence
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	Measured	438	High confidence	2925.57	2853.65	1.0252
		581	Low confidence	2015.65	1932.95	1.04278
	Ranked	327	High confidence	9897.29	10466.5	1.05751
		501	Low confidence	10721.7	11352.1	1.0588
	Squared	477	High confidence	18353.1	18218.3	1.0074
		703	Low confidence	10851.4	10485.1	1.03494

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.