Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Value Type Gene Interaction Map red description green Network Comparison Type Filtered network_comparison
Results: HTML CSV LaTeX Showing element 51 to 100 of 3730 in total
Value Type  : Measured
Interaction Map  : High confidence
Network Comparison Type  : Divided
Rank
red
description
green
Filtered
network_comparison
26 153 fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] 662 0 4.3268
1833.01 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6] 892.67 1 2.0534
27 570 phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] 139 0 4.10072
1834.33 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] 895.134 1 2.04922
28 570 beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938] 139 0 4.10072
1834.36 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798] 895.194 1 2.04912
29 111.278 potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 434.911 0 3.90833
1834.52 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08] 895.507 1 2.04858
30 427.217 dystrophin. [swissprot;acc:p11532] 111.739 0 3.82335
1834.59 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670] 895.633 1 2.04837
31 35 dok-like protein. [refseq;acc:nm_024872] 0.00001 0 3500000
1834.63 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151] 895.697 1 2.04827
32 598 cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336] 184 0 3.25
1834.73 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] 895.893 1 2.04793
33 12.6208 lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 39.8063 0 3.15402
1835.3 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152] 896.972 1 2.04611
34 143 glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] 47 0 3.04255
1836.71 guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992] 907.546 1 2.02382
35 459.5 adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236] 1377 0 2.99674
1836.71 guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148] 907.564 1 2.02378
36 157 heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174] 56 0 2.80357
1836.76 guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086] 907.741 1 2.02344
37 334.401 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 934.348 0 2.79409
1836.76 guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488] 907.763 1 2.02339
38 320.012 zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623] 120.429 0 2.65727
1836.76 guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087] 907.774 1 2.02337
39 482.426 microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268] 192.295 0 2.50878
1836.8 guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899] 907.903 1 2.02312
40 377 nanos (fragment). [sptrembl;acc:q8wy41] 151 0 2.49669
1836.81 guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898] 907.978 1 2.02297
41 266 nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718] 645 0 2.42481
1836.81 guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754] 907.978 1 2.02297
42 205.439 presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341] 86.9525 0 2.36266
1857.32 guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775] 958.237 1 1.93827
43 263.66 elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897] 587.988 0 2.2301
1881.02 guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520] 1027.36 1 1.83093
44 45.4292 acyl-coa dehydrogenase, short/branched chain specific, mitochondrial precursor (ec 1.3.99.-) (sbcad) (2-methyl branched chain acyl-coa dehydrogenase) (2-mebcad) (2-methylbutyryl-coenzyme a dehydrogenase) (2-methylbutyryl-coa dehydrogenase). [swissprot;acc:p45954] 98.5074 0 2.16837
1931.34 guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901] 1057.39 1 1.82652
45 202.374 tigger transposable element derived 6. [refseq;acc:nm_030953] 438.605 0 2.1673
1926.69 guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0] 1056.02 1 1.82448
46 202.163 tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208] 438.035 0 2.16674
779.167 neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784] 1390.33 1 1.78438
47 202.156 tigger transposable element derived 1; jerky (mouse) homolog-like. [refseq;acc:nm_145702] 438.016 0 2.16672
779.167 chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873] 1390.33 1 1.78438
48 doc-1 related protein (doc-1r). [swissprot;acc:o75956]
870.482 deltex homolog 1; hdx-1. [refseq;acc:nm_004416] 403.196 0 2.15895
49 72 selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611] 151 2.09722
779.167 neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8] 1390.33 1 1.78438
50 44 transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884] 21 0 2.09524
779.167 neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562] 1390.33 1 1.78438

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/