Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Interaction Map Filtered red Network Comparison Type network_comparison green
Results: HTML CSV LaTeX Showing element 182 to 231 of 3228 in total 
Value Type	Ranked
Interaction Map	High confidence
Filtered	1
Network Comparison Type	Divided

Rank	description	red	network_comparison	green	
182	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [source:swissprot;acc:o14929]	277.546	1.15422	240.461	
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [source:swissprot;acc:p52298]	228.306	1.153	198.011	
184	odd-skipped related 1; odz (odd oz/ten-m) related 1. [source:refseq;acc:nm_145260]	274.027	1.15239	237.79	
185	adiponectin receptor 2. [source:refseq;acc:nm_024551]	281.582	1.14292	246.371	
186	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [source:refseq;acc:nm_001457]	226.582	1.14179	198.444	
187	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [source:refseq;acc:nm_016316]	226.582	1.14179	198.444	
188	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [source:swissprot;acc:q99873]	226.582	1.14179	198.444	
189	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [source:swissprot;acc:q9nr22]	226.582	1.14179	198.444	
190	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [source:swissprot;acc:p08621]	226.582	1.14179	198.444	
191	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [source:swissprot;acc:p21333]	226.582	1.14179	198.444	
192	musashi 2 isoform a. [source:refseq;acc:nm_138962]	227.491	1.14055	199.458	
193	musashi 1. [source:refseq;acc:nm_002442]	227.491	1.14055	199.458	
194	nuclear protein ukp68. [source:refseq;acc:nm_024824]	227.491	1.14055	199.458	
195	huntingtin interacting protein c. [source:refseq;acc:nm_012272]	227.971	1.13748	200.417	
196	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [source:refseq;acc:nm_138457]	263.215	1.13745	231.407	
197	forkhead box protein p1 (hspc215). [source:swissprot;acc:q9h334]	263.215	1.13745	231.407	
198	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [source:swissprot;acc:q9bzs1]	263.191	1.13741	231.394	
199	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [source:swissprot;acc:q9umr5]	242.735	1.13729	276.059	
200	egf-like-domain, multiple 7; neu1 protein. [source:refseq;acc:nm_016215]	242.718	1.1372	276.018	
201	splicing factor 4 isoform b; rna-binding protein. [source:refseq;acc:nm_021164]	240.133	1.13601	211.382	
202	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [source:swissprot;acc:q9ubn4]	201.478	1.13553	228.784	
203	ebp50-pdz interactor of 64 kda (epi64 protein). [source:swissprot;acc:q9bxi6]	201.515	1.13516	228.752	
204	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [source:swissprot;acc:q9ul62]	201.515	1.13516	228.752	
205	luc7-like 2; cgi-74 protein; cgi-59 protein. [source:refseq;acc:nm_016019]	228.1	1.13501	200.968	
206	luc7-like; sarcoplasmic reticulum protein luc7b1. [source:refseq;acc:nm_018032]	228.085	1.13472	201.006	
207	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [source:swissprot;acc:p49810]	285.684	1.13261	252.234	
208	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [source:swissprot;acc:p34991]	285.684	1.13261	252.234	
209	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [source:refseq;acc:nm_018315]	285.684	1.13261	252.234	
210	cullin homolog 2 (cul-2). [source:swissprot;acc:q13617]	285.684	1.13261	252.234	
211	presenilin 1 (ps-1) (s182 protein). [source:swissprot;acc:p49768]	285.684	1.13261	252.234	
212	cullin homolog 1 (cul-1). [source:swissprot;acc:q13616]	285.684	1.13261	252.234	
213	pallidin; pallid (mouse) homolog, pallidin. [source:refseq;acc:nm_012388]	210.693	1.127	186.95	
214	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [source:refseq;acc:nm_022075]	191.644	1.12605	170.192	
215	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [source:swissprot;acc:p13533]	112	1.125	126	
216	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [source:swissprot;acc:q9y623]	112	1.125	126	
217	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [source:swissprot;acc:p13535]	112	1.125	126	
218	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [source:swissprot;acc:q9ukx2]	112	1.125	126	
219	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [source:swissprot;acc:p11055]	112	1.125	126	
220	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [source:swissprot;acc:p12882]	112	1.125	126	
221	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [source:swissprot;acc:p12883]	112	1.125	126	
222	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [source:sptrembl;acc:q9h430]	112	1.125	126	
223	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [source:swissprot;acc:q9ukx3]	112	1.125	126	
224	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [source:swissprot;acc:q16348]	185.969	1.12285	165.623	
225	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [source:swissprot;acc:p43330]	226.471	1.12243	201.769	
226	cartilage oligomeric matrix protein precursor (comp). [source:swissprot;acc:p49747]	239.991	1.12187	269.238	
227	thrombospondin 3 precursor. [source:swissprot;acc:p49746]	239.99	1.12186	269.234	
228	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [source:refseq;acc:nm_005489]	226.411	1.12036	202.088	
229	breast cancer antiestrogen resistance 3. [source:refseq;acc:nm_003567]	226.401	1.12028	202.094	
230	cysteine-rich protein 1 (crp1) (crp). [source:swissprot;acc:p21291]	239.35	1.11934	267.915	
231	likely ortholog of mouse shc sh2-domain binding protein 1. [source:refseq;acc:nm_024745]	239.336	1.11927	267.881	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/