MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Network Comparison Type	Rank	Value Type	green	description	Interaction Map	red	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 25824 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	green	description	red	network_comparison
13	Squared	388.696	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	37.5863	10.3414
	Rooted	35.798		19.9625	1.79326
14	Measured	1281.5	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	398.5	3.21581
	Ranked	75.3531	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	56.6768	1.32952
	Squared	388.696	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	37.5863	10.3414
	Rooted	35.798		19.9625	1.79326
15	Measured	871	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	2671	3.06659
	Ranked	75.3948	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	56.7244	1.32914
	Squared	179.56	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	1688.58	9.40399
	Rooted	42.4773	gbp protein isoform a. [refseq;acc:nm_017870]	23.9771	1.77158
16	Measured	871	protein x 0004. [refseq;acc:nm_016301]	2671	3.06659
	Ranked	75.3954	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	56.7252	1.32913
	Squared	179.56	protein x 0004. [refseq;acc:nm_016301]	1688.58	9.40399
	Rooted	29.5127	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	51.6817	1.75117
17	Measured	1365	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	460	2.96739
	Ranked	75.447	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	56.7841	1.32866
	Squared	441	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	50.0828	8.80542
	Rooted	29.5127	protein x 0004. [refseq;acc:nm_016301]	51.6817	1.75117
18	Measured	1865.5	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	677.5	2.75351
	Ranked	245.247	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	185.678	1.32082
	Squared	823.69	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	108.641	7.58176
	Rooted	36.9459	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	21.4476	1.72261
19	Measured	1865.5	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	677.5	2.75351
	Ranked	245.247	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	185.678	1.32082
	Squared	823.69	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	108.641	7.58176
	Rooted	43.561	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	25.6987	1.69507
20	Measured	1865.5	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	677.5	2.75351
	Ranked	245.247	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	185.678	1.32082
	Squared	823.69	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	108.641	7.58176
	Rooted	24.2744	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	40.3337	1.66157
21	Measured	1865.5	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	677.5	2.75351
	Ranked	245.247	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	185.678	1.32082
	Squared	823.69	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	108.641	7.58176
	Rooted	24.2744	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	40.3337	1.66157
22	Measured	1865.5	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	677.5	2.75351
	Ranked	245.247	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	185.678	1.32082
	Squared	823.69	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	108.641	7.58176
	Rooted	24.2915	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	40.3357	1.66049
23	Measured	1894.39	gbp protein isoform a. [refseq;acc:nm_017870]	699.76	2.7072
	Ranked	44	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	58	1.31818
	Squared	457.521	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	143.692	3.18404
	Rooted	24.2919	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	40.3358	1.66046
24	Measured	2108.52	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	950.561	2.21818
	Ranked	44	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	58	1.31818
	Squared	457.521	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	143.692	3.18404
	Rooted	24.2941	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	40.336	1.66032
25	Measured	892.67	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	1833.01	2.0534
	Ranked	44	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	58	1.31818
	Squared	457.521	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	143.692	3.18404
	Rooted	24.295	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	40.3361	1.66026

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.