MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Rank	Gene	Filtered	Interaction Map	Network Comparison Type	Value Type	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 14920 in total

Interaction Map  : High confidence
Network Comparison Type  : Divided

description	Rank	Filtered	Value Type	network_comparison	red	green
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	18	1	Ranked	1.32082	185.678	245.247
	37	0	Measured	2.79409	334.401	934.348
			Squared	10.2338	101.05	1034.13
	53		Rooted	1.5213	11.844	18.0183
	60	1	Measured	1.6231	4489.19	2765.82
	64		Rooted	1.35128	63.8686	47.2654
	242	0	Ranked	1.09822	15260.6	13895.8
	245	1	Squared	1.31131	8875.01	6768.05
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	295			1.27733	30807.7	39351.7
	509		Measured	1.14278	7551.8	8630.06
	805		Rooted	1.0645	74.3557	79.1513
	1038		Ranked	1.03148	186.741	181.041
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	294		Squared	1.2776	30826.5	39383.9
	508		Measured	1.14293	7556.75	8636.87
	804		Rooted	1.0646	74.3877	79.1931
	1032		Ranked	1.03162	186.664	180.943
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	311		Squared	1.27154	30566.4	38866.5
	514		Measured	1.1411	7477	8532.02
	822		Rooted	1.06393	73.8577	78.5795
	1048		Ranked	1.031	187.96	182.308
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	308		Squared	1.27205	30596.2	38919.9
	513		Measured	1.14143	7485.08	8543.66
	811		Rooted	1.06415	73.9102	78.6514
	1043		Ranked	1.03128	187.834	182.137
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	3126		Measured	1	0.00001	0.00001
			Ranked
			Squared
			Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	588		Squared	1.18502	23526.4	27879.3
	1136		Measured	1.08864	5790.65	6303.92
	1907		Rooted	1.02906	63.4353	65.2789
	1963		Ranked	1.00978	211.633	213.703
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	2922		Measured	1	0.00001	0.00001
			Ranked
			Squared
			Rooted
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	1143		Squared	1.14046	28551.5	32561.8
	1411		Measured	1.07743	5812.02	6262.07
	1943		Rooted	1.02853	61.3337	63.0838
	2439		Ranked	1.00337	220.681	221.425
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	3088		Measured	1	0.00001	0.00001
			Ranked
			Squared
			Rooted
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	1135		Squared	1.14128	28600.9	32641.7
	1415		Measured	1.0774	5815.33	6265.44
	1961		Rooted	1.02824	61.3419	63.0743
	2396		Ranked	1.00375	220.683	221.51
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	921		Squared	1.15651	25739.7	29768.2
	1600		Measured	1.07145	6336.22	6788.96

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.