MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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green	Filtered	Value Type	network_comparison	Gene	Interaction Map	Rank	red	description	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 1 to 50 of 77072 in total

green  : 0
Filtered  : 0
Network Comparison Type  : Subtracted

Value Type	network_comparison	Interaction Map	Rank	red	description
Measured	0	High confidence	494	0	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]
			495		histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]
			496		mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]
			497		histone h2a; h2a histone family, member r. [refseq;acc:nm_170745]
			498		translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]
			499		homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
			500		rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]
			501		h2a histone family, member j isoform 1. [refseq;acc:nm_018267]
			502		brca1 associated protein. [refseq;acc:nm_006768]
		Low confidence	837		gamma-glutamyltranspeptidase 2 (ec 2.3.2.2) (gamma-glutamyltransferase 2) (fragment). [swissprot;acc:p36268]
			838		gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [refseq;acc:nm_080920]
			839		cobw-like protein. [refseq;acc:nm_018491]
			840		translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]
			841		gamma-glutamyltransferase. [sptrembl;acc:q14390]
			842		gamma-glutamyltranspeptidase 1 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 1) (cd224 antigen). [swissprot;acc:p19440]
			843		gamma-glutamyltranspeptidase 5 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 5) (ggt-rel). [swissprot;acc:p36269]
	2.31962		822	2.31962	tbc1 domain family, member 8 (with gram domain); vascular rab-gap/tbc-containing. [refseq;acc:nm_007063]
	13		777	13	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
	18	High confidence	429	18	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]
	35		386	35	dok-like protein. [refseq;acc:nm_024872]
	37	Low confidence	648	37	carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [refseq;acc:nm_021615]
			649		carbohydrate (n-acetylglucosamine-6-o) sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 2. [refseq;acc:nm_004267]
	60	High confidence	338	60	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]
	82		316	82	ero1-like. [refseq;acc:nm_014584]
	154		206	154	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]
			207		transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]
	286	Low confidence	200	286	neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531]
			201		neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]
	364	High confidence	88	364	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]
		Low confidence	170
Ranked	0	High confidence	501	0	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
			502		brca1 associated protein. [refseq;acc:nm_006768]
		Low confidence	837		gamma-glutamyltranspeptidase 2 (ec 2.3.2.2) (gamma-glutamyltransferase 2) (fragment). [swissprot;acc:p36268]
			838		gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [refseq;acc:nm_080920]
			839		cobw-like protein. [refseq;acc:nm_018491]
			841		gamma-glutamyltransferase. [sptrembl;acc:q14390]
			842		gamma-glutamyltranspeptidase 1 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 1) (cd224 antigen). [swissprot;acc:p19440]
			843		gamma-glutamyltranspeptidase 5 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 5) (ggt-rel). [swissprot;acc:p36269]
Squared		High confidence	494		histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]
			495		histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]
			496		mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]
			497		histone h2a; h2a histone family, member r. [refseq;acc:nm_170745]
			498		translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]
			499		homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
			500		rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]
			501		h2a histone family, member j isoform 1. [refseq;acc:nm_018267]
			502		brca1 associated protein. [refseq;acc:nm_006768]
		Low confidence	837		gamma-glutamyltranspeptidase 2 (ec 2.3.2.2) (gamma-glutamyltransferase 2) (fragment). [swissprot;acc:p36268]
			838		gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [refseq;acc:nm_080920]
			839		cobw-like protein. [refseq;acc:nm_018491]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.