MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Rank	Interaction Map	Gene	green	description	network_comparison	red	Filtered

Results: HTML CSV LaTeX

Showing element 501 to 550 of 77072 in total

Network Comparison Type  : Divided
Value Type  : Measured

Rank	Interaction Map	green	description	network_comparison	red	Filtered
126	High confidence	635.875	calcyphosine. [swissprot;acc:q13938]	1.3457	472.524	0
		18164.9	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	1.33499	24250	1
	Low confidence	2407.27	fos-related antigen 2. [swissprot;acc:p15408]	1.33179	3205.98	0
		10318.5	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	1.0937	11285.3	1
127	High confidence	64	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	1.34375	86	0
		7523.39	transcription factor jun-d. [swissprot;acc:p17535]	1.33436	5638.2	1
	Low confidence	511.5	ubiquinol-cytochrome c reductase complex 7.2 kda protein (ec 1.10.2.2) (cytochrome c1, nonheme 7 kda protein) (complex iii subunit x) (7.2 kda cytochrome c1-associated protein subunit) (hspc119). [swissprot;acc:q9udw1]	1.3304	680.5	0
		10318.5	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	1.0937	11285.3	1
128	High confidence	60.8613	mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]	1.33918	81.504	0
		5810.82	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	1.3341	4355.61	1
	Low confidence	391	double-stranded rna-specific editase 1 (ec 3.5.-.-) (dsrna adenosine deaminase) (rna editing deaminase 1) (rna editing enzyme 1). [swissprot;acc:p78563]	1.32993	294	0
		10318.5	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	1.0937	11285.3	1
129	High confidence	454.837	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	1.33341	606.485	0
		5811.49	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	1.33348	4358.13	1
	Low confidence	194.326	amiloride-sensitive sodium channel delta-subunit (epithelial na+ channel delta subunit) (delta enac) (nonvoltage-gated sodium channel 1 delta subunit) (scned) (delta nach). [swissprot;acc:p51172]	1.32901	146.219	0
		10318.5	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	1.0937	11285.3	1
130	High confidence	56	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	1.33333	42	0
		2978.53	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	1.33287	2234.68	1
	Low confidence	937.501	phosphatidylinositol 4-kinase alpha (ec 2.7.1.67) (pi4-kinase) (ptdins-4-kinase) (pi4k-alpha). [swissprot;acc:p42356]	1.32453	707.801	0
		10318.5	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	1.0937	11285.3	1
131	High confidence	56	serpin b11. [swissprot;acc:q96p15]	1.33333	42	0
		2978.57	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	1.33285	2234.73	1
	Low confidence	851.77	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	1.31954	645.504	0
		10318.5	trophinin. [swissprot;acc:q12816]	1.0937	11285.3	1
132	High confidence	56	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	1.33333	42	0
		2980.35	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	1.33253	2236.61	1
	Low confidence	191.971	wd-repeat protein 5 (wd-repeat protein big-3). [swissprot;acc:q9ugp9]	1.31242	251.947	0
		5441.83	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	1.09318	5948.88	1
133	High confidence	335	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	1.32937	252	0
		17580.4	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	1.33225	23421.5	1
	Low confidence	1139	cdc42-binding protein kinase beta; cdc42-binding protein kinase beta (dmpk-like); mrck beta; dmpk-like. [refseq;acc:nm_006035]	1.3032	874	0
		7662.77	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	1.09265	7013	1
134	High confidence	346.751	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	1.32862	260.986	0
		16426.1	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	1.32626	21785.2	1
	Low confidence	1139	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]	1.3032	874	0
		7286.66	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	1.09242	6670.21	1
135	High confidence	613.614	rna polymerase i transcription factor rrn3. [refseq;acc:nm_018427]	1.32736	814.485	0
		16426.1	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	1.32626	21785.2	1
	Low confidence	203.832	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	1.30261	265.513	0
		7916.96	high-mobility group 20a. [refseq;acc:nm_018200]	1.09226	7248.24	1
136	High confidence	1150.51	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	1.3267	1526.38	0
		4763.34	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	1.31556	3620.77	1
	Low confidence	154.324	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	1.30138	200.834	0
		7667.34	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	1.09214	7020.48	1
137	High confidence	1233.41	heat shock factor binding protein 1. [swissprot;acc:o75506]	1.3225	1631.18	0
		4763.34	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	1.31556	3620.77	1
	Low confidence	154.279	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	1.30127	200.759	0
		6699.58	t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]	1.09121	6139.6	1
138	High confidence	154.804	ubiquitin-conjugating enzyme e2-17 kda 3 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (e2(17)kb 3). [swissprot;acc:p47986]	1.32026	204.382	0
		2094.3	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	1.31555	2755.15	1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.