MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	green	Interaction Map	Value Type	network_comparison	red	Gene	Rank	Network Comparison Type	description

Results: HTML CSV LaTeX

Showing element 451 to 500 of 77072 in total

Filtered  : 0

green	Interaction Map	Value Type	network_comparison	red	Rank	Network Comparison Type	description
3.87298	High confidence	Rooted	2.87298	1	192	Subtracted	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]
			3.87298		23	Divided
3.99932		Squared	3.12701	0.872309	427	Subtracted	adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377]
			4.58475		51	Divided
4.11238	Low confidence		1.61589	2.49649	800	Subtracted	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]
			1.64726		142	Divided
4.17869			0.68559	3.4931	811	Subtracted	phenol-sulfating phenol sulfotransferase 1 (ec 2.8.2.1) (p-pst) (thermostable phenol sulfotransferase) (ts-pst) (hast1/hast2) (st1a3). [swissprot;acc:p50225]
			1.19627		280	Divided
4.1804			0.68915	3.49125	809	Subtracted	phenol-sulfating phenol sulfotransferase 2 (ec 2.8.2.1) (p-pst) (st1a2). [swissprot;acc:p50226]
					810		monoamine-sulfating phenol sulfotransferase (ec 2.8.2.1) (sulfotransferase, monoamine-preferring) (m-pst) (thermolabile phenol sulfotransferase) (tl-pst) (placental estrogen sulfotransferase) (catecholamine-sulfating phenol sulfotransferase) (hast3). [swissprot;acc:p50224]
			1.19739		276	Divided	phenol-sulfating phenol sulfotransferase 2 (ec 2.8.2.1) (p-pst) (st1a2). [swissprot;acc:p50226]
					277		monoamine-sulfating phenol sulfotransferase (ec 2.8.2.1) (sulfotransferase, monoamine-preferring) (m-pst) (thermolabile phenol sulfotransferase) (tl-pst) (placental estrogen sulfotransferase) (catecholamine-sulfating phenol sulfotransferase) (hast3). [swissprot;acc:p50224]
4.24264	High confidence	Rooted	4.24264	0	116	Subtracted	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]
			424264	0.00001	14	Divided
4.3589			0.43693	4.79583	445	Subtracted	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]
			1.10024		263	Divided
	Low confidence		0.43693		722	Subtracted
			1.10024		359	Divided
			2.28266	9.94987	18		camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]
			5.59097		50	Subtracted
4.57302	High confidence	Squared	16.8159	76.8994	32	Divided	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]
					33		beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]
			72.3264		303	Subtracted	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]
					304		beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]
	Low confidence		16.8159		21	Divided
			72.3264		628	Subtracted
4.58258	High confidence	Rooted	1.44749	6.63325	61	Divided	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]
			2.05067		274	Subtracted
4.6274			1.1455	3.4819	352		lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]
			1.32899		88	Divided
	Low confidence		1.1455		544	Subtracted
			1.32899		93	Divided
4.74982	High confidence	Squared	1.71779	8.15919	146		ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]
			3.40937		424	Subtracted
4.90793			1.68639	8.27669	149	Divided	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]
			2.0736	2.36686	105		dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]
			2.54107		433	Subtracted
			3.36876	8.27669	425		putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]
5.11062	Low confidence		4.17059	21.3143	60	Divided	fos39347_1. [sptrembl;acc:o75863]
			16.2037		736	Subtracted
5.12693	High confidence	Rooted	3.47237	17.8026	27	Divided	dystrophin. [swissprot;acc:p11532]
			12.6757		16	Subtracted
5.15101	Low confidence	Squared	4.12321	21.2387	62	Divided	dj254p11.1 (novel protein similar to rna polymerase ii elongation factor siii, subunit p15). [sptrembl;acc:q9h575]
			16.0877		738	Subtracted
5.24885	High confidence		1.67729	8.80383	152	Divided	40s ribosomal protein s26. [swissprot;acc:p02383]
			3.55498		423	Subtracted
5.33358			8.22384	43.8625	39	Divided	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]
			38.5289		343	Subtracted
5.38516	Low confidence	Rooted	1.28654	6.9282	102	Divided	abl-philin 2. [refseq;acc:nm_032327]
			1.54304		457	Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.