Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type description Interaction Map Rank Network Comparison Type red Gene Filtered green network_comparison
Results: HTML CSV LaTeX Showing element 975 to 1024 of 3228 in total 
Value Type	Measured
Interaction Map	High confidence
Network Comparison Type	Divided
Filtered	1

description	Rank	red	green	network_comparison	
eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [source:swissprot;acc:o15371]	1597	5665.34	6070.32	1.07148	
eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [source:swissprot;acc:q99613]	923	4057.54	4457.66	1.09861	
eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [source:swissprot;acc:p55884]	684	4359.82	4880.99	1.11954	
eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [source:swissprot;acc:q04637]	186	4071.1	5251.75	1.29001	
eukaryotic translation initiation factor 4 gamma, 3. [source:refseq;acc:nm_003760]	181	4068.56	5252.6	1.29102	
eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [source:swissprot;acc:p06730]	393	4490.28	5222.25	1.16301	
eukaryotic translation initiation factor 5 (eif-5). [source:swissprot;acc:p55010]	273	3199.4	3870.8	1.20985	
eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [source:swissprot;acc:p10159]	1612	6212.98	6655.12	1.07116	
eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [source:swissprot;acc:p56537]	506	3893.85	4450.98	1.14308	
evolutionarily conserved g-patch domain containing. [source:refseq;acc:nm_018025]	1652	5944.24	6358.1	1.06962	
evolutionarily conserved signaling intermediate in toll pathway; ecsit. [source:refseq;acc:nm_016581]	1537	6184.27	6637.44	1.07328	
exocyst complex component exo70. [source:swissprot;acc:q9upt5]	2781	0.00001	0.00001	1	
exocyst complex component sec10 (hsec10). [source:swissprot;acc:o00471]	1438	6721.25	7238.34	1.07693	
exocyst complex component sec15a. [source:swissprot;acc:q8tag9]	1068	6201.54	6774.35	1.09237	
exocyst complex component sec15b. [source:swissprot;acc:q9y2d4]	1083	6213.51	6785.04	1.09198	
exocyst complex component sec3 (bm-012). [source:swissprot;acc:q9nv70]	2048	6036.68	6379.44	1.05678	
exocyst complex component sec5. [source:swissprot;acc:q96kp1]	286	23316	19288.8	1.20878	
exocyst complex component sec6. [source:swissprot;acc:o60645]	2135	7387.42	7785.45	1.05388	
exocyst complex component sec8. [source:swissprot;acc:q96a65]	1311	6221.22	6727.77	1.08142	
exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [source:refseq;acc:nm_006027]	2170	5825.61	6126.74	1.05169	
exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [source:swissprot;acc:q13868]	2594	4921.84	5005.06	1.01691	
exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [source:swissprot;acc:q9nqt5]	2595	4921.84	5005.06	1.01691	
exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [source:swissprot;acc:q9npd3]	2593	4921.84	5005.06	1.01691	
exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [source:swissprot;acc:q9nqt4]	2596	4921.84	5005.06	1.01691	
exportin 1; exportin-1 (required for chromosome region maintenance); exportin 1 (crm1, yeast, homolog); crm1, yeast, homolog. [source:refseq;acc:nm_003400]	826	5195.58	5750.34	1.10678	
eyes absent homolog 1. [source:swissprot;acc:q99502]	2268	5785.08	6051.03	1.04597	
eyes absent homolog 2. [source:swissprot;acc:o00167]	2299	5786.15	6050.71	1.04572	
eyes absent homolog 3. [source:swissprot;acc:q99504]	2274	5779.66	6044.78	1.04587	
eyes absent homolog 4. [source:swissprot;acc:o95677]	2296	5784.9	6049.99	1.04582	
ezrin-binding partner pace-1 isoform 1. [source:refseq;acc:nm_020423]	3228	0.00001	0.00001	1	
f-actin capping protein alpha-1 subunit (capz alpha-1). [source:swissprot;acc:p52907]	1490	6340.5	6815.41	1.0749	
f-actin capping protein alpha-2 subunit (capz alpha-2). [source:swissprot;acc:p47755]	1497	6339.08	6812.45	1.07467	
f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [source:swissprot;acc:q96kx2]	1681	6304.74	6740.66	1.06914	
f-actin capping protein beta subunit (capz beta). [source:swissprot;acc:p47756]	1682	6304.74	6740.66	1.06914	
f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [source:refseq;acc:nm_018315]	100	2353.63	3225.65	1.3705	
fad synthetase. [source:refseq;acc:nm_025207]	1841	3591.95	3375.34	1.06417	
far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [source:refseq;acc:nm_003902]	2092	5817.41	6138.8	1.05525	
farnesyl pyrophosphate synthetase (fpp synthetase) (fps) (farnesyl diphosphate synthetase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10)]. [source:swissprot;acc:p14324]	1180	4392.63	4776.19	1.08732	
fas apoptotic inhibitory molecule. [source:refseq;acc:nm_018147]	2307	5666.91	5923.48	1.04528	
fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [source:refseq;acc:nm_013402]	2370	5265.95	5492.28	1.04298	
fatty acid desaturase 2; linoleoyl-coa desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase. [source:refseq;acc:nm_004265]	2369	5265.95	5492.28	1.04298	
fatty acid desaturase 3; linoleoyl-coa desaturase (delta-6-desaturase)-like 3; delta-6 fatty acid desaturase. [source:refseq;acc:nm_021727]	2367	5265.95	5492.28	1.04298	
fatty acid hydroxylase domain containing 1. [source:refseq;acc:nm_024306]	2204	5076.73	5326.29	1.04916	
fatty acid-binding protein, adipocyte (afabp) (adipocyte lipid-binding protein) (albp) (a-fabp). [source:swissprot;acc:p15090]	1665	5791.14	6193.02	1.0694	
fatty acid-binding protein, brain (b-fabp) (brain lipid-binding protein) (blbp) (mammary derived growth inhibitor related). [source:swissprot;acc:o15540]	1667	5791.14	6193.02	1.0694	
fatty acid-binding protein, epidermal (e-fabp) (psoriasis-associated fatty acid-binding protein homolog) (pa-fabp). [source:swissprot;acc:q01469]	1666	5791.14	6193.02	1.0694	
fatty acid-binding protein, heart (h-fabp) (muscle fatty acid-binding protein) (m-fabp) (mammary-derived growth inhibitor) (mdgi). [source:swissprot;acc:p05413]	1674	5791.14	6193.02	1.0694	
fatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldh class 3). [source:swissprot;acc:p51648]	3181	0.00001	0.00001	1	
fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [source:swissprot;acc:o00519]	1951	5888.32	6245.89	1.06073	
fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [source:refseq;acc:nm_015322]	403	5201.41	4479.76	1.16109	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/