MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Filtered	Interaction Map	Gene	Value Type	green	Rank	red	network_comparison	Network Comparison Type

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Showing element 1 to 50 of 38536 in total

Network Comparison Type  : Divided

description	Filtered	Interaction Map	Value Type	green	Rank	red	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	0	High confidence	Measured	934.348	37	334.401	2.79409
			Ranked	13895.8	242	15260.6	1.09822
			Squared	1034.13	37	101.05	10.2338
			Rooted	18.0183	53	11.844	1.5213
		Low confidence	Measured	851.77	131	645.504	1.31954
			Ranked	13590.3	629	13205.3	1.02915
			Squared	1268.51	146	775.72	1.63527
			Rooted	17.0804	537	16.298	1.04801
	1	High confidence	Measured	2765.82	60	4489.19	1.6231
			Ranked	245.247	18	185.678	1.32082
			Squared	6768.05	245	8875.01	1.31131
			Rooted	47.2654	64	63.8686	1.35128
		Low confidence	Measured	7900.54	4914	7853.62	1.00597
			Ranked	201.5	4130	199.383	1.01062
			Squared	41688.5	1119	43628.5	1.04654
			Rooted	72.6287	4914	71.9496	1.00944
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]		High confidence	Measured	8630.06	509	7551.8	1.14278
			Ranked	181.041	1038	186.741	1.03148
			Squared	39351.7	295	30807.7	1.27733
			Rooted	79.1513	805	74.3557	1.0645
		Low confidence	Measured	8585.64	885	8255.95	1.03993
			Ranked	194.038	1328	198.342	1.02218
			Squared	45736	4562	46617.7	1.01928
			Rooted	76.3375	1092	73.5001	1.0386
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]		High confidence	Measured	8636.87	508	7556.75	1.14293
			Ranked	180.943	1032	186.664	1.03162
			Squared	39383.9	294	30826.5	1.2776
			Rooted	79.1931	804	74.3877	1.0646
		Low confidence	Measured	8587.03	880	8256.68	1.04001
			Ranked	194.014	1322	198.322	1.0222
			Squared	45740.5	4569	46616.1	1.01914
			Rooted	76.3467	1084	73.5068	1.03863
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]		High confidence	Measured	8532.02	514	7477	1.1411
			Ranked	182.308	1048	187.96	1.031
			Squared	38866.5	311	30566.4	1.27154
			Rooted	78.5795	822	73.8577	1.06393
		Low confidence	Measured	9081.29	237	8530.51	1.06457
			Ranked	185.859	588	191.507	1.03039
			Squared	47372.8	4138	46138.2	1.02676
			Rooted	79.5804	378	75.8843	1.04871
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]		High confidence	Measured	8543.66	513	7485.08	1.14143
			Ranked	182.137	1043	187.834	1.03128
			Squared	38919.9	308	30596.2	1.27205
			Rooted	78.6514	811	73.9102	1.06415
		Low confidence	Measured	9018.94	252	8492.92	1.06194
			Ranked	186.751	637	192.166	1.029
			Squared	47088.3	4418	46049.4	1.02256
			Rooted	79.1997	427	75.6219	1.04731
1-aminocyclopropane-1-carboxylate synthase. [refseq;acc:nm_032592]			Measured	8323.04	2035	8065.05	1.03199
			Ranked	196.707	3423	199.702	1.01523

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.