MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	description	Filtered	Rank	Network Comparison Type	green	red	Value Type	network_comparison	Interaction Map

Results: HTML CSV LaTeX

Showing element 1 to 50 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Filtered	Rank	green	red	Value Type	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	0	37	934.348	334.401	Measured	2.79409
			1034.13	101.05	Squared	10.2338
		53	18.0183	11.844	Rooted	1.5213
		242	13895.8	15260.6	Ranked	1.09822
	1	18	245.247	185.678		1.32082
		60	2765.82	4489.19	Measured	1.6231
		64	47.2654	63.8686	Rooted	1.35128
		245	6768.05	8875.01	Squared	1.31131
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]		295	39351.7	30807.7		1.27733
		509	8630.06	7551.8	Measured	1.14278
		805	79.1513	74.3557	Rooted	1.0645
		1038	181.041	186.741	Ranked	1.03148
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]		294	39383.9	30826.5	Squared	1.2776
		508	8636.87	7556.75	Measured	1.14293
		804	79.1931	74.3877	Rooted	1.0646
		1032	180.943	186.664	Ranked	1.03162
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]		311	38866.5	30566.4	Squared	1.27154
		514	8532.02	7477	Measured	1.1411
		822	78.5795	73.8577	Rooted	1.06393
		1048	182.308	187.96	Ranked	1.031
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]		308	38919.9	30596.2	Squared	1.27205
		513	8543.66	7485.08	Measured	1.14143
		811	78.6514	73.9102	Rooted	1.06415
		1043	182.137	187.834	Ranked	1.03128
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]		3126	0.00001	0.00001	Measured	1
					Ranked
					Squared
					Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]		588	27879.3	23526.4	Squared	1.18502
		1136	6303.92	5790.65	Measured	1.08864
		1907	65.2789	63.4353	Rooted	1.02906
		1963	213.703	211.633	Ranked	1.00978
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]		2922	0.00001	0.00001	Measured	1
					Ranked
					Squared
					Rooted
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]		1143	32561.8	28551.5	Squared	1.14046
		1411	6262.07	5812.02	Measured	1.07743
		1943	63.0838	61.3337	Rooted	1.02853
		2439	221.425	220.681	Ranked	1.00337
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]		3088	0.00001	0.00001	Measured	1
					Ranked
					Squared
					Rooted
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]		1135	32641.7	28600.9	Squared	1.14128
		1415	6265.44	5815.33	Measured	1.0774
		1961	63.0743	61.3419	Rooted	1.02824
		2396	221.51	220.683	Ranked	1.00375
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]		921	29768.2	25739.7	Squared	1.15651
		1600	6788.96	6336.22	Measured	1.07145

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.