MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	Rank	network_comparison	Interaction Map	description	red	green	Filtered

Results: HTML CSV LaTeX

Showing element 1130 to 1179 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	description	red	green
1130	1.08864	similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]	5790.65	6303.92
1131		aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]
1132		alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]
1133		golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]
1134		alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]
1135		methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252]	5790.67	6303.95
1136		10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	5790.65	6303.92
1137		rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]
1138		oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8]
1139		choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329]	5790.66	6303.95
1140		voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [swissprot;acc:q13303]	5790.65	6303.93
1141		aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]
1142	1.0886	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294]	5789.07	6302.01
1143	1.08858	homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]	6281.21	6837.61
1144		cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]
1145		40s ribosomal protein s30. [swissprot;acc:q05472]	5893.97	6416.07
1146		activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]	6281.21	6837.61
1147		cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]
1148		hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]
1149	1.08857	transducin-like enhancer protein 3 (esg3). [swissprot;acc:q04726]	6280.74	6837.01
1150	1.08841	mstp028 protein. [refseq;acc:nm_031954]	5838.87	6355.06
1151	1.08838	alpha-centractin (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). [swissprot;acc:p42024]	5322.74	5793.15
1152		beta-centractin (actin-related protein 1b) (arp1b). [swissprot;acc:p42025]
1153	1.08828	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily b member 1 (integrase interactor 1 protein) (hsnf5) (baf47). [swissprot;acc:q12824]	5840.01	6355.56
1154	1.08821	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	5840.65	6355.84
1155	1.0882	transducin-like enhancer protein 4. [swissprot;acc:q04727]	6270.67	6823.73
1156	1.08819	polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]	5840.77	6355.89
1157	1.08801	serine hydroxymethyltransferase, cytosolic (ec 2.1.2.1) (serine methylase) (glycine hydroxymethyltransferase) (shmt). [swissprot;acc:p34896]	5418.33	5895.2
1158	1.08797	delta-aminolevulinic acid dehydratase (ec 4.2.1.24) (porphobilinogen synthase) (aladh). [swissprot;acc:p13716]	5489.18	5972.09
1159	1.08787	kccr13l. [refseq;acc:nm_139179]	5538.8	6025.51
1160		dna repair protein rad51 homolog 1 (hrad51) (hsrad51). [swissprot;acc:q06609]
1161	1.08783	n-acetyltransferase 5 (ec 2.3.1.-). [swissprot;acc:q9y6d2]	5315.76	5782.63
1162	1.0877	nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231]	5832.13	6343.59
1163		elks protein. [refseq;acc:nm_015064]
1164	1.08764	sodium/iodide cotransporter (na(+)/i(-) cotransporter) (sodium-iodide symporter) (na+/i-symporter). [swissprot;acc:q92911]	6600.36	7178.84
1165	1.08761	kidney and liver proline oxidase 1. [refseq;acc:nm_021232]	6604.44	7183.07
1166	1.0876	solute carrier family 5 (iodide transporter), member 8; apical iodide transporter. [refseq;acc:nm_145913]	6606.3	7185.01
1167	1.08759	sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289]	6607.68	7186.45
1168	1.08757	mitotic checkpoint protein bub3. [swissprot;acc:o43684]	5470.44	5949.49
1169		zinc finger protein 207. [swissprot;acc:o43670]
1170	1.08747	ubiquitin-like protein smt3a. [swissprot;acc:p55854]	5826.34	6335.98
1171		ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	5826.29	6335.93
1172		acrc protein; putative nuclear protein. [refseq;acc:nm_052957]	5826.32	6335.95
1173	1.08735	chaperone-activity of bc1 complex-like, mitochondrial precursor (chaperone-abc1-like). [swissprot;acc:q8ni60]	5799.35	6305.95
1174		cda11 protein. [refseq;acc:nm_032026]	5874.11	6387.23
1175		aarf domain containing kinase 2; putative ubiquinone biosynthesis protein aarf. [refseq;acc:nm_052853]	5799.35	6305.95
1176		aarf domain containing kinase 4. [refseq;acc:nm_024876]
1177		aarf domain containing kinase 1. [refseq;acc:nm_020421]
1178	1.08732	pepsin a precursor (ec 3.4.23.1). [swissprot;acc:p00790]	4392.63	4776.19
1179		solute carrier family 20 (phosphate transporter), member 2; glvr-2; pit-2; gibbon ape leukemia virus receptor 2; murine leukemia virus, amphotropic; receptor. [refseq;acc:nm_006749]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.