MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Filtered	green	Value Type	Rank	Gene	description	Network Comparison Type	network_comparison	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 451 to 500 of 77072 in total

Filtered  : 0

green	Value Type	Rank	description	Network Comparison Type	network_comparison	Interaction Map	red
3.87298	Rooted	23	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	Divided	3.87298	High confidence	1
		192		Subtracted	2.87298
3.99932	Squared	51	adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377]	Divided	4.58475		0.872309
		427		Subtracted	3.12701
4.11238		142	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	Divided	1.64726	Low confidence	2.49649
		800		Subtracted	1.61589
4.17869		280	phenol-sulfating phenol sulfotransferase 1 (ec 2.8.2.1) (p-pst) (thermostable phenol sulfotransferase) (ts-pst) (hast1/hast2) (st1a3). [swissprot;acc:p50225]	Divided	1.19627		3.4931
		811		Subtracted	0.68559
4.1804		276	phenol-sulfating phenol sulfotransferase 2 (ec 2.8.2.1) (p-pst) (st1a2). [swissprot;acc:p50226]	Divided	1.19739		3.49125
		277	monoamine-sulfating phenol sulfotransferase (ec 2.8.2.1) (sulfotransferase, monoamine-preferring) (m-pst) (thermolabile phenol sulfotransferase) (tl-pst) (placental estrogen sulfotransferase) (catecholamine-sulfating phenol sulfotransferase) (hast3). [swissprot;acc:p50224]
		809	phenol-sulfating phenol sulfotransferase 2 (ec 2.8.2.1) (p-pst) (st1a2). [swissprot;acc:p50226]	Subtracted	0.68915
		810	monoamine-sulfating phenol sulfotransferase (ec 2.8.2.1) (sulfotransferase, monoamine-preferring) (m-pst) (thermolabile phenol sulfotransferase) (tl-pst) (placental estrogen sulfotransferase) (catecholamine-sulfating phenol sulfotransferase) (hast3). [swissprot;acc:p50224]
4.24264	Rooted	14	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	Divided	424264	High confidence	0.00001
		116		Subtracted	4.24264		0
4.3589		18	camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]	Divided	2.28266	Low confidence	9.94987
		50		Subtracted	5.59097
		263	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	Divided	1.10024	High confidence	4.79583
		359				Low confidence
		445		Subtracted	0.43693	High confidence
		722				Low confidence
4.57302	Squared	21	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	Divided	16.8159		76.8994
		32	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]			High confidence
		33	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]
		303	phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	Subtracted	72.3264
		304	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]
		628				Low confidence
4.58258	Rooted	61	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]	Divided	1.44749	High confidence	6.63325
		274		Subtracted	2.05067
4.6274		88	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	Divided	1.32899		3.4819
		93				Low confidence
		352		Subtracted	1.1455	High confidence
		544				Low confidence
4.74982	Squared	146	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Divided	1.71779	High confidence	8.15919
		424		Subtracted	3.40937
4.90793		105	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	Divided	2.0736		2.36686
		149	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]		1.68639		8.27669
		425		Subtracted	3.36876
		433	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]		2.54107		2.36686
5.11062		60	fos39347_1. [sptrembl;acc:o75863]	Divided	4.17059	Low confidence	21.3143
		736		Subtracted	16.2037
5.12693	Rooted	16	dystrophin. [swissprot;acc:p11532]		12.6757	High confidence	17.8026
		27		Divided	3.47237
5.15101	Squared	62	dj254p11.1 (novel protein similar to rna polymerase ii elongation factor siii, subunit p15). [sptrembl;acc:q9h575]		4.12321	Low confidence	21.2387
		738		Subtracted	16.0877
5.24885		152	40s ribosomal protein s26. [swissprot;acc:p02383]	Divided	1.67729	High confidence	8.80383
		423		Subtracted	3.55498
5.33358		39	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	Divided	8.22384		43.8625
		343		Subtracted	38.5289
5.38516	Rooted	102	abl-philin 2. [refseq;acc:nm_032327]	Divided	1.28654	Low confidence	6.9282
		457		Subtracted	1.54304

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.