Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Filtered Gene Value Type network_comparison Rank description green Interaction Map Network Comparison Type red
Results: HTML CSV LaTeX Showing element 501 to 550 of 29840 in total
Filtered  : 0
Value Type  : Measured
Interaction Map  : High confidence
network_comparison
Rank
description
green
Network Comparison Type
red
3.04255 34 glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] 47 Divided 143
3.072 466 sprouty homolog 4 (spry-4). [swissprot;acc:q9c004] 796.85 Subtracted 793.778
3.15402 33 lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 39.8063 Divided 12.6208
3.25 32 cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336] 184 598
3.82335 30 dystrophin. [swissprot;acc:p11532] 111.739 427.217
3.901 465 alpha-nac protein. [sptrembl;acc:q9h009] 151.122 Subtracted 147.221
3.90833 29 potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 434.911 Divided 111.278
4 464 adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559] 19 Subtracted 23
4.087 463 nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594] 150.709 146.622
4.10072 27 phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] 139 Divided 570
28 beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]
4.3268 26 fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] 662 153
4.687 462 survival motor neuron protein (component of gems 1) (gemin1). [swissprot;acc:q16637] 701.071 Subtracted 705.758
5.015 461 transcription initiation factor tfiid 20/15 kda subunits (tafii- 20/tafii-15) (tafii20/tafii15). [swissprot;acc:q16514] 604.911 599.896
5.22297 25 potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110] 773 Divided 148
5.26667 24 ptd016 protein. [refseq;acc:nm_016125] 158 30
5.3334 460 4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404] 14.3333 Subtracted 19.6667
5.5 459 testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562] 206.5 201
6.73106 21 syntaxin 10 (syn10). [swissprot;acc:o60499] 17.6611 Divided 118.878
7.7 458 adenylosuccinate synthase-like 1. [refseq;acc:nm_152328] 1310.67 Subtracted 1318.37
8 457 3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8] 5046.33 5038.33
8.1 456 glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410] 226.81 218.71
8.112 455 glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409] 227.143 219.031
8.118 454 glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189] 227.308 219.19
8.821 453 protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237] 533.236 524.415
9.32 452 60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] 219.891 229.211
9.76 451 dead/h (asp-glu-ala-asp/his) box polypeptide 11; dead/h box-11 (chl1-related helicase gene-1); yeast chl1 homolog. [refseq;acc:nm_030655] 1372.31 1362.55
11.6763 18 60s ribosomal protein l37a. [swissprot;acc:p12751] 26.1599 Divided 305.45
19 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]
12 450 methyltransferase like 2. [refseq;acc:nm_018396] 43 Subtracted 31
13.333 449 protein c20orf45 (cgi-107). [swissprot;acc:q9y3b1] 546 532.667
13.498 448 syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623] 156.3 142.802
13.501 447 tbp-associated factor 9l; neuronal cell death-related protein; taf9-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 31 kd; neuronal cell death-related gene in neuron-7; transcription associated factor tafii31l; transcription initiation factor iid, 31kd subunit. [refseq;acc:nm_015975] 485.852 472.351
13.8767 446 suppressor of actin 1. [refseq;acc:nm_014016] 37.4843 23.6076
14 442 maspin precursor (protease inhibitor 5). [swissprot;acc:p36952] 56 42
443 protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992] 15 1
444 serpin b11. [swissprot;acc:q96p15] 56 42
445 cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
14.077 440 forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488] 149.371 135.294
441 interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]
14.51 439 dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374] 1248.14 1262.65
14.553 438 dead (asp-glu-ala-asp) box polypeptide 47; hqp0256 protein. [refseq;acc:nm_016355] 161.091 175.644
14.8103 17 mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849] 58 Divided 859
15 16 protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992] 15 1
15.287 437 importin 4. [refseq;acc:nm_024658] 476.639 Subtracted 491.926
15.6 15 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521] 156 Divided 10
15.88 436 ischemia/reperfusion inducible protein. [refseq;acc:nm_024640] 1483.62 Subtracted 1467.74
16.74 435 alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652] 2335.98 2319.24
17.27 434 26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232] 2263.85 2281.12
17.465 433 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] 359.98 377.445

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/