MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Network Comparison Type	Gene	Hugo	Value Type	description	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 644 to 693 of 2060 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
red  : 0
network_comparison  : 0
green  : 0

Rank	Hugo	Value Type	description
2916	PRPS1L1	Rooted	ribose-phosphate pyrophosphokinase i (ec 2.7.6.1) (phosphoribosyl pyrophosphate synthetase i) (ppribp) (prs-i). [swissprot;acc:p09329]
2917	CCT6A	Measured	t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227]
		Ranked
		Squared
		Rooted
2918	GBAS	Measured	nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323]
		Ranked
		Squared
		Rooted
2919	GLRA1	Measured	glycine receptor alpha-1 chain precursor (glycine receptor 48 kda subunit) (strychnine binding subunit). [swissprot;acc:p23415]
		Ranked
		Squared
		Rooted
2920	GLRA3	Measured	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]
		Ranked
		Squared
		Rooted
2921	EAF2	Measured	ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456]
		Ranked
		Squared
		Rooted
2922	ALDH1L1	Measured	10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]
		Ranked
		Squared
		Rooted
2923	TMEM4	Measured	transmembrane protein 4. [refseq;acc:nm_014255]
		Ranked
		Squared
		Rooted
2924	RQCD1	Measured	rcd1 required for cell differentiation1 homolog; protein involved in sexual development; rcd1 (required for cell differentiation, s.pombe) homolog 1. [refseq;acc:nm_005444]
		Ranked
		Squared
		Rooted
2925	RALB	Measured	ras-related protein ral-b. [swissprot;acc:p11234]
		Ranked
		Squared
		Rooted
2926	DUSP11	Measured	dual specificity protein phosphatase 11 (ec 3.1.3.48) (rna/rnp complex-intereracting phosphatase) (phosphatase that interacts with rna/rnp complex 1). [swissprot;acc:o75319]
		Ranked
		Squared
		Rooted
2927	CIAO1	Measured	wd-repeat containing protein ciao 1. [swissprot;acc:o76071]
		Ranked
		Squared
		Rooted
2928	no value	Measured	calmodulin. [swissprot;acc:p02593]
		Ranked
		Squared
		Rooted
2929	LYST	Measured	lysosomal trafficking regulator (beige homolog). [swissprot;acc:q99698]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.