MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	Value Type	description	Filtered	green	Network Comparison Type	Interaction Map	network_comparison	red

Results: HTML CSV LaTeX

Showing element 501 to 550 of 38536 in total

Network Comparison Type  : Divided

Rank	Value Type	description	Filtered	green	Interaction Map	network_comparison	red
32	Ranked	importin 9. [refseq;acc:nm_018085]	0	8691.76	High confidence	1.52929	13292.2
		myoglobin. [swissprot;acc:p02144]		15983.3	Low confidence	1.39162	11485.4
		protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	1	232.49		1.17505	273.188
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]		243.673	High confidence	1.29985	187.462
	Squared	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		25146.6		2.53372	9924.76
		melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		61881.5	Low confidence	1.33073	82347.8
		melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	0	0.355148		9.62112	3.41692
		phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]		4.57302	High confidence	16.8159	76.8994
	Rooted	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	1	43.1914		1.65937	26.0288
		melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	0	5.80678	Low confidence	1.69589	9.84765
		mitochondrial solute carrier protein. [refseq;acc:nm_145305]	1	168.796		1.1597	145.551
		ubiquitin protein ligase. [refseq;acc:nm_130466]	0	11.258	High confidence	2.13529	24.0391
33	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	1	896.972		2.04611	1835.3
		lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	0	39.8063		3.15402	12.6208
		melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		35.5	Low confidence	2.97183	105.5
		vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	1	43368.8		1.19275	36360.3
	Ranked	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]		246.125		1.17068	210.241
		fk506-binding protein 6 (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (36 kda fk506 binding protein) (fkbp- 36) (immunophilin fkbp36). [swissprot;acc:o75344]	0	14746.1		1.37827	20324.1
		nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]		8691.76	High confidence	1.52929	13292.2
		serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	1	242.742		1.28647	188.688
	Squared	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	0	4.57302		16.8159	76.8994
		hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	1	61881.5	Low confidence	1.33073	82347.8
		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	0	0.355148		9.62112	3.41692
		spermatogenesis associated 6. [refseq;acc:nm_019073]	1	25146.6	High confidence	2.53372	9924.76
	Rooted	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	0	25.7294		2.0801	12.3693
		melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]		5.80678	Low confidence	1.69589	9.84765
		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	1	43.1914	High confidence	1.65937	26.0288
		retinoblastoma-associated factor 600. [refseq;acc:nm_020765]		88.6244	Low confidence	1.15738	76.5734
34	Measured	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	0	47	High confidence	3.04255	143
		guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	1	907.546		2.02382	1836.71
		melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	0	35.5	Low confidence	2.97183	105.5
		protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	1	6352.4		1.1897	5339.5
	Ranked	fibrillin 3. [refseq;acc:nm_032447]	0	7506.66		1.37724	5450.5
		microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]		17173.8	High confidence	1.52196	11284
		putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	1	133.876	Low confidence	1.16197	155.56
		serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]		242.453	High confidence	1.28235	189.07
	Squared	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]		25146.6		2.53372	9924.76
		lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	0	0.697197		15.9968	0.0435834
		melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	1	61881.5	Low confidence	1.33073	82347.8
		melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	0	0.355148		9.62112	3.41692
	Rooted	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	1	24.3678	High confidence	1.65305	40.2812
		melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	0	5.80678	Low confidence	1.69589	9.84765
		phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]		11.7898	High confidence	2.02503	23.8747
		putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	1	56.755	Low confidence	1.15698	49.0544
35	Measured	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	0	1377	High confidence	2.99674	459.5
		deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	1	39358.1	Low confidence	1.18866	33111.4
		guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]		907.564	High confidence	2.02378	1836.71
		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	0	35.5	Low confidence	2.97183	105.5
	Ranked	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		4871.6	High confidence	1.5182	3208.8
		nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	1	204.309		1.27519	260.532

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.