MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	Value Type	green	Network Comparison Type	Interaction Map	red	description	network_comparison	Filtered

Results: HTML CSV LaTeX

Showing element 2008 to 2057 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	green	red	description	network_comparison
2008	222.969	225.019	receptor protein-tyrosine kinase erbb-3 precursor (ec 2.7.1.112) (c-erbb3) (tyrosine kinase-type cell surface receptor her3). [swissprot;acc:p21860]	1.00919
2009	214.245	216.201	proteasome subunit beta type 10 precursor (ec 3.4.25.1) (proteasome mecl-1) (macropain subunit mecl-1) (multicatalytic endopeptidase complex subunit mecl-1). [swissprot;acc:p40306]	1.00913
2010	191.766	193.517	tubulin-specific chaperone c (tubulin-folding cofactor c) (cfc). [swissprot;acc:q15814]
2011			putative acyl-coa thioester hydrolase cgi-16 (ec 3.1.2.-). [swissprot;acc:q9y305]
2012			dead-box protein. [refseq;acc:nm_018665]
2013	215.693	217.662	protein phosphatase 1, regulatory (inhibitor) subunit 12b isoform a; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2. [refseq;acc:nm_002481]
2014	215.709	217.676	protein phosphatase 1, regulatory (inhibitor) subunit 12a; myosin phosphatase, target subunit 1. [refseq;acc:nm_002480]	1.00912
2015	215.979	217.941	dna topoisomerase iii alpha (ec 5.99.1.2). [swissprot;acc:q13472]	1.00908
2016	197.301	199.092	electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134]
2017	128.553	127.397	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	1.00907
2018			serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]
2019	213.865	215.799	acyl-coa dehydrogenase, short/branched chain specific, mitochondrial precursor (ec 1.3.99.-) (sbcad) (2-methyl branched chain acyl-coa dehydrogenase) (2-mebcad) (2-methylbutyryl-coenzyme a dehydrogenase) (2-methylbutyryl-coa dehydrogenase). [swissprot;acc:p45954]	1.00904
2020	221.176	223.168	putative eukaryotic translation initiation factor 3 subunit (eif-3) (fragment). [swissprot;acc:o75153]	1.00901
2021	210.464	208.601	hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor (ec 2.1.1.114) (dihydroxyhexaprenylbenzoate methyltransferase) (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (dhhb methyltransferase) (dhhb-mt) (dhhb-mtase). [swissprot;acc:q9nzj6]	1.00893
2022			atp synthase coupling factor b, mitochondrial precursor. [swissprot;acc:q99766]
2023			guanine deaminase (ec 3.5.4.3) (guanase) (guanine aminase) (guanine aminohydrolase) (gah) (p51-nedasin). [swissprot;acc:q9y2t3]
2024	213.663	215.553	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	1.00885
2025	191.668	189.987	alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298]
2026	213.663	215.553	vacuolar protein sorting 11 (hvps11) (pp3476). [swissprot;acc:q9h270]
2027	223.041	225.015	lin-7 homolog c; lin-7 protein 3. [refseq;acc:nm_018362]
2028	213.663	215.553	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]
2029	191.677	189.999	cytoplasmic cysteine conjugate-beta lyase; glutamine-phenylpyruvate aminotransferase. [refseq;acc:nm_004059]	1.00883
2030			alanine aminotransferase 2; glutamic-pyruvate transaminase 2. [refseq;acc:nm_133443]
2031	216.562	218.466	traf and tnf receptor-associated protein; ets1-associated protein 2. [refseq;acc:nm_016614]	1.00879
2032	213.46	215.322	f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	1.00872
2033			f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]
2034	220.812	218.919	centaurin beta 5 (cnt-b5). [swissprot;acc:q96p50]	1.00865
2035			centaurin beta 2 (cnt-b2). [swissprot;acc:q15057]
2036	220.813		lamin b1. [swissprot;acc:p20700]
2037	220.812		centaurin beta 1 (cnt-b1). [swissprot;acc:q15027]
2038	220.811	218.92	lamin a/c (70 kda lamin). [swissprot;acc:p02545]	1.00864
2039	192.191	190.551	acetyl-coenzyme a synthetase, cytoplasmic (ec 6.2.1.1) (acetate--coa ligase) (acyl-activating enzyme) (acetyl-coa synthetase) (acs) (acecs). [swissprot;acc:q9nr19]	1.00861
2040	208.803	210.586	brachyury protein (t protein). [swissprot;acc:o15178]	1.00854
2041	195.141	196.808	ataxin-1 ubiquitin-like interacting protein. [refseq;acc:nm_020131]
2042	208.803	210.586	t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]
2043	195.173	196.837	ubiquilin 1 isoform 1. [refseq;acc:nm_013438]	1.00853
2044	198.24	199.928	adapter-related protein complex 3 beta 1 subunit (beta-adaptin 3a) (ap-3 complex beta-3a subunit) (beta-3a-adaptin). [swissprot;acc:o00203]	1.00851
2045			ny-ren-24 antigen (fragment). [sptrembl;acc:q9y5a4]
2046			adapter-related protein complex 3 beta 2 subunit (beta-adaptin 3b) (ap-3 complex beta-3b subunit) (beta-3b-adaptin) (neuron-specific vesicle coat protein beta-nap). [swissprot;acc:q13367]
2047	226.003	224.124	solute carrier family 2, facilitated glucose transporter, member 6 (glucose transporter type 6) (glucose transporter type 9). [swissprot;acc:q9ugq3]	1.00838
2048			solute carrier family 2, facilitated glucose transporter, member 8 (glucose transporter type 8) (glucose transporter type x1). [swissprot;acc:q9ny64]
2049	222.634	220.787	translation initiation factor eif-2b beta subunit (eif-2b gdp-gtp exchange factor) (s20i15) (s20iii15). [swissprot;acc:p49770]	1.00837
2050	216.981	218.79	sh3 domain-binding glutamic acid-rich protein (sh3bgr protein) (21- glutamic acid-rich protein) (21-garp). [swissprot;acc:p55822]	1.00834
2051			oxidation resistance 1. [refseq;acc:nm_181354]
2052	205.95	207.667	ornithine decarboxylase antizyme inhibitor. [swissprot;acc:o14977]
2053	216.981	218.79	lats, large tumor suppressor, homolog 2; lats (large tumor suppressor, drosophila) homolog 2. [refseq;acc:nm_014572]
2054	205.948	207.665	ornithine decarboxylase-like protein (ec 4.1.1.17) (odc-paralogue) (odc-p). [swissprot;acc:q96a70]
2055	216.981	218.79	dymeclin. [refseq;acc:nm_017653]
2056			sh3 domain-binding glutamic acid-rich-like protein. [swissprot;acc:o75368]
2057			lats homolog 1. [refseq;acc:nm_004690]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.