Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 763 to 812 of 25824 in total 
Interaction Map	High confidence
Filtered	1

Rank	description	Value Type	Network Comparison Type	red	green	network_comparison	
96	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [source:swissprot;acc:p04899]	Rooted	Subtracted	40.28	24.37	15.91	
96	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [source:refseq;acc:nm_022075]	Measured	Divided	4110.14	5694.99	1.3856	
96	melanoma-associated antigen 8 (mage-8 antigen). [source:swissprot;acc:p43361]	Ranked	Divided	88.2482	110.265	1.24949	
96	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [source:swissprot;acc:q96t37]	Rooted	Divided	47.6504	36.9304	1.29028	
96	septin-like protein kiaa0202 (fragment). [source:swissprot;acc:q92599]	Measured	Subtracted	16177.9	19235.4	3057.5	
96	septin-like protein kiaa0202 (fragment). [source:swissprot;acc:q92599]	Squared	Subtracted	90226	126939	36713	
97	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [source:swissprot;acc:q02410]	Measured	Divided	2820.51	3897.1	1.3817	
97	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [source:swissprot;acc:q02410]	Ranked	Subtracted	271.752	225.68	46.072	
97	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [source:refseq;acc:nm_006693]	Squared	Divided	227160	146079	1.55505	
97	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [source:swissprot;acc:p33240]	Squared	Subtracted	126408	89940.5	36467.5	
97	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [source:swissprot;acc:p04898]	Rooted	Subtracted	40.2797	24.3705	15.9092	
97	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [source:swissprot;acc:o60732]	Ranked	Divided	88.2482	110.265	1.24949	
97	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [source:swissprot;acc:o76081]	Rooted	Divided	47.6504	36.9304	1.29028	
97	septin 10 isoform 1. [source:refseq;acc:nm_144710]	Measured	Subtracted	16067.4	19094.4	3027	
98	brain protein 44. [source:swissprot;acc:o95563]	Measured	Subtracted	15999.1	19007.1	3008	
98	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [source:swissprot;acc:p08754]	Rooted	Subtracted	40.2797	24.3705	15.9092	
98	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [source:swissprot;acc:p43365]	Ranked	Divided	88.2482	110.265	1.24949	
98	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [source:swissprot;acc:p49810]	Measured	Divided	2353.63	3225.65	1.3705	
98	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [source:swissprot;acc:p01100]	Ranked	Subtracted	204.641	160.957	43.684	
98	septin 10 isoform 1. [source:refseq;acc:nm_144710]	Squared	Subtracted	89578.7	125883	36304.3	
98	transcription factor lbx1. [source:swissprot;acc:p52954]	Rooted	Divided	47.6504	36.9304	1.29028	
98	trs85 homolog. [source:swissprot;acc:q9y2l5]	Squared	Divided	227160	146079	1.55505	
99	brain protein 44. [source:swissprot;acc:o95563]	Squared	Subtracted	89182.8	125229	36046.2	
99	jun dimerization protein. [source:refseq;acc:nm_130469]	Ranked	Subtracted	204.641	160.957	43.684	
99	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [source:swissprot;acc:p43355]	Ranked	Divided	88.2482	110.265	1.24949	
99	mosaic protein lgn. [source:swissprot;acc:p81274]	Rooted	Divided	47.6504	36.9304	1.29028	
99	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [source:swissprot;acc:p34991]	Measured	Divided	2353.63	3225.65	1.3705	
99	septin 7 (cdc10 protein homolog). [source:swissprot;acc:q16181]	Measured	Subtracted	15999.1	19007.1	3008	
99	tob2 protein (transducer of erbb-2 2). [source:swissprot;acc:q14106]	Rooted	Subtracted	19.9625	35.798	15.8355	
99	wd-repeat protein wdc146. [source:swissprot;acc:q9c0j8]	Squared	Divided	226186	145568	1.55382	
100	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [source:swissprot;acc:q10570]	Squared	Divided	226186	145568	1.55382	
100	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [source:refseq;acc:nm_018315]	Measured	Divided	2353.63	3225.65	1.3705	
100	fos-related antigen 2. [source:swissprot;acc:p15408]	Ranked	Subtracted	204.641	161.046	43.595	
100	melanoma-associated antigen 10 (mage-10 antigen). [source:swissprot;acc:p43363]	Ranked	Divided	88.2482	110.265	1.24949	
100	regulator of g-protein signaling 17 (rgs17). [source:swissprot;acc:q9ugc6]	Rooted	Divided	47.6504	36.9304	1.29028	
100	septin 6. [source:swissprot;acc:q14141]	Measured	Subtracted	15959.9	18957.1	2997.2	
100	septin 7 (cdc10 protein homolog). [source:swissprot;acc:q16181]	Squared	Subtracted	89182.8	125229	36046.2	
100	tob1 protein (transducer of erbb-2 1). [source:swissprot;acc:p50616]	Rooted	Subtracted	19.9625	35.798	15.8355	
101	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [source:swissprot;acc:q9p2i0]	Squared	Divided	222655	143584	1.5507	
101	cullin homolog 2 (cul-2). [source:swissprot;acc:q13617]	Measured	Divided	2353.63	3225.65	1.3705	
101	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [source:refseq;acc:nm_032552]	Rooted	Subtracted	19.9625	35.798	15.8355	
101	guanine nucleotide-binding protein g(o), alpha subunit 1. [source:swissprot;acc:p09471]	Rooted	Divided	47.6504	36.9304	1.29028	
101	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [source:swissprot;acc:p43366]	Ranked	Divided	88.2482	110.265	1.24949	
101	protein fosb (g0/g1 switch regulatory protein 3). [source:swissprot;acc:p53539]	Ranked	Subtracted	204.641	161.051	43.59	
101	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [source:swissprot;acc:o43236]	Measured	Subtracted	14924.4	17655.2	2730.8	
101	septin 6. [source:swissprot;acc:q14141]	Squared	Subtracted	88953.6	124854	35900.4	
102	associated molecule with the sh3 domain of stam (amsh) like protein. [source:refseq;acc:nm_020799]	Measured	Subtracted	11068	8508.5	2559.5	
102	cytoplasmic polyadenylation element binding protein 4. [source:refseq;acc:nm_030627]	Rooted	Subtracted	19.9625	35.798	15.8355	
102	fip1-like 1; rearranged in hypereosinophilia. [source:refseq;acc:nm_030917]	Squared	Divided	214143	138337	1.54798	
102	fos-related antigen 1 (fra-1). [source:swissprot;acc:p15407]	Ranked	Subtracted	204.642	161.068	43.574	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/