Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Value Type Network Comparison Type green Rank Interaction Map description red Filtered network_comparison
Results: HTML CSV LaTeX Showing element 501 to 550 of 12912 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
green
Rank
description
red
network_comparison
1056.02 45 guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0] 1926.69 1.82448
1057.39 44 guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901] 1931.34 1.82652
1281.5 9 tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106] 398.5 3.21581
10 tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]
11 dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]
12 cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]
13 cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]
14 ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]
1365 17 dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8] 460 2.96739
1390.33 46 neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784] 779.167 1.78438
47 chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]
48 doc-1 related protein (doc-1r). [swissprot;acc:o75956]
49 neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]
50 neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]
51 neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]
52 chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]
53 cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]
1695.45 88 potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 2411.93 1.42259
1698.12 89 cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929] 2414.22 1.4217
1698.75 90 potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980] 2414.77 1.4215
1700.8 91 potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979] 2416.53 1.42082
1865.5 18 protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256] 677.5 2.75351
19 microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]
20 protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]
21 ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]
22 protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]
1894.39 23 gbp protein isoform a. [refseq;acc:nm_017870] 699.76 2.7072
2094.3 138 kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] 2755.15 1.31555
2099.49 139 potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] 2759.61 1.31442
2100.27 140 kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] 2760.28 1.31425
2108.52 24 protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690] 950.561 2.21818
2394.5 1 rad50-interacting protein 1. [refseq;acc:nm_021930] 450.5 5.31521
2 rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]
2579.49 274 chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286] 3119.98 1.20953
275 regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]
276 putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]
277 regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]
278 transcription factor lbx1. [swissprot;acc:p52954]
279 mosaic protein lgn. [swissprot;acc:p81274]
280 regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]
281 guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]
282 rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]
2651.88 54 deltex 2. [refseq;acc:nm_020892] 1618.84 1.63814
2662.12 55 deltex homolog 1; hdx-1. [refseq;acc:nm_004416] 1629.21 1.63399
2664.55 56 t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492] 1631.67 1.63302
57 kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]
58 kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]
59 kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]
2690.25 65 neuralized-like. [refseq;acc:nm_004210] 1657.68 1.6229
2765.82 60 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 4489.19 1.6231

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/