MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	Filtered	red	network_comparison	Interaction Map	Value Type	description	Network Comparison Type	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 3228 in total

Filtered  : 1
Interaction Map  : High confidence
Value Type  : Measured
Network Comparison Type  : Divided

Rank	red	network_comparison	description	green
1	450.5	5.31521	rad50-interacting protein 1. [refseq;acc:nm_021930]	2394.5
2			rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]
3	2597.5	3.71868	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	698.5
4			hbs1-like. [refseq;acc:nm_006620]
5	1153.5	3.39764	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	339.5
6			junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]
7			sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]
8			db83 protein. [swissprot;acc:p57088]
9	398.5	3.21581	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	1281.5
10			tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]
11			dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]
12			cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]
13			cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]
14			ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]
15	2671	3.06659	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	871
16			protein x 0004. [refseq;acc:nm_016301]
17	460	2.96739	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	1365
18	677.5	2.75351	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	1865.5
19			microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]
20			protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]
21			ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]
22			protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]
23	699.76	2.7072	gbp protein isoform a. [refseq;acc:nm_017870]	1894.39
24	950.561	2.21818	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	2108.52
25	1833.01	2.0534	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	892.67
26			guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]
27	1834.33	2.04922	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	895.134
28	1834.36	2.04912	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	895.194
29	1834.52	2.04858	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	895.507
30	1834.59	2.04837	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	895.633
31	1834.63	2.04827	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	895.697
32	1834.73	2.04793	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	895.893
33	1835.3	2.04611	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	896.972
34	1836.71	2.02382	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	907.546
35		2.02378	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	907.564
36	1836.76	2.02344	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	907.741
37		2.02339	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	907.763
38		2.02337	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	907.774
39	1836.8	2.02312	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	907.903
40	1836.81	2.02297	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	907.978
41			guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]
42	1857.32	1.93827	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	958.237
43	1881.02	1.83093	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	1027.36
44	1931.34	1.82652	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	1057.39
45	1926.69	1.82448	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	1056.02
46	779.167	1.78438	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	1390.33
47			chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]
48			doc-1 related protein (doc-1r). [swissprot;acc:o75956]
49			neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]
50			neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.