MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Network Comparison Type	Value Type	green	Gene	description	Rank	network_comparison	red	Filtered	Interaction Map

Results: HTML CSV LaTeX

Showing element 2163 to 2212 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

green	description	Rank	network_comparison	red
218.72	rho-gtpase-activating protein 1 (gtpase-activating protein rhoogap) (rho-related small gtpase protein activator) (cdc42 gtpase-activating protein) (p50-rhogap). [swissprot;acc:q07960]	2480	1.00287	218.093
	rho-gtpase-activating protein 8. [swissprot;acc:q9nsg0]	2479
	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	2486
218.792	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	602	1.06069	206.274
	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	601
218.802	myb-related protein a (a-myb). [swissprot;acc:p10243]	1548	1.01696	222.512
218.823	myb-related protein b (b-myb). [swissprot;acc:p10244]	1547	1.01699	222.541
218.837	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	450	1.07815	235.94
218.878	pdz/coiled-coil domain binding partner for the rho-family gtpase tc10; fused in glioblastoma; golgi associated pdz and coiled-coil motif containing protein; cftr-associated ligand. [refseq;acc:nm_020399]	914	1.03801	210.863
	prip-interacting protein pipmt; prip-interacting protein with methyltransferase domain. [refseq;acc:nm_024831]	913
218.893	dna repair protein rad51 homolog 1 (hrad51) (hsrad51). [swissprot;acc:q06609]	2345	1.0045	219.878
	kccr13l. [refseq;acc:nm_139179]	2344
218.92	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	1541	1.01714	222.672
218.925	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	458	1.07764	235.922
218.982	ammecr1 protein. [refseq;acc:nm_015365]	1577	1.01645	222.585
	mrna-associated protein mrnp 41 (rae1 protein homolog). [swissprot;acc:p78406]	1578
	nuclear pore complex protein nup98 (nucleoporin nup98) (98 kda nucleoporin). [swissprot;acc:p52948]	1576
	scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680]	1575
	tata element modulatory factor (tmf). [swissprot;acc:p82094]	1574
218.984	antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]	2418	1.00359	218.2
	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	2415
	megsin (tp55) (serpin b7). [swissprot;acc:o75635]	2414
	oxysterols receptor lxr-alpha (liver x receptor alpha) (nuclear orphan receptor lxr-alpha). [swissprot;acc:q13133]	2422
	oxysterols receptor lxr-beta (liver x receptor beta) (nuclear orphan receptor lxr-beta) (ubiquitously-expressed nuclear receptor) (nuclear receptor ner). [swissprot;acc:p55055]	2416
	serpin b12. [swissprot;acc:q96p63]	2413
	squamous cell carcinoma antigen 1 (scca-1) (protein t4-a). [swissprot;acc:p29508]	2420
	translation initiation factor eif-2b alpha subunit (eif-2b gdp-gtp exchange factor). [swissprot;acc:q14232]	2419
	upf0183 protein. [swissprot;acc:q9bsu1]	2417
218.991	brca1-associated ring domain protein 1 (bard-1). [swissprot;acc:q99728]	1752	1.01258	216.271
219.001	l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	881	1.03928	227.604
219.008	n-myc proto-oncogene protein. [swissprot;acc:p04198]	882	1.03924	227.601
219.014	26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	2395	1.00377	218.192
219.017	ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]	883	1.03917	227.596
	ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]	884
	nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217]	885
219.018	elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]	886
219.024	atp-dependent dna helicase q5 (recq protein-like 5) (recq5). [swissprot;acc:o94762]	1703	1.01363	216.079
	dna-repair protein xrcc3 (x-ray repair cross-complementing protein 3). [swissprot;acc:o43542]	1702
	glucose-6-phosphate 1-dehydrogenase (ec 1.1.1.49) (g6pd). [swissprot;acc:p11413]	1701
219.037	myc proto-oncogene protein (c-myc). [swissprot;acc:p01106]	893	1.03903	227.585
219.05	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	2326	1.00468	220.076
219.081	nucleolar protein family a, member 2; component of the h/aca snornp. [refseq;acc:nm_017838]	1734	1.01296	221.921
	transcription initiation factor iif, alpha subunit (tfiif-alpha) (transcription initiation factor rap74). [swissprot;acc:p35269]	1736
219.09	megf6 (fragment). [sptrembl;acc:o75095]	1756	1.01242	221.811
219.157	cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]	1426	1.02068	214.717
	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	1425
	sodium/potassium-transporting atpase alpha-1 chain precursor (ec 3.6.3.9) (sodium pump 1) (na+/k+ atpase 1). [swissprot;acc:p05023]	1424
	sodium/potassium-transporting atpase alpha-2 chain precursor (ec 3.6.3.9) (sodium pump 2) (na+/k+ atpase 2). [swissprot;acc:p50993]	1428
	sodium/potassium-transporting atpase alpha-3 chain (ec 3.6.3.9) (sodium pump 3) (na+/k+ atpase 3) (alpha(iii)). [swissprot;acc:p13637]	1427
219.195	brain protein 16. [refseq;acc:nm_016458]	1847	1.011	216.811

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.