Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Network Comparison Type Value Type Interaction Map red Filtered network_comparison green
Results: HTML CSV LaTeX Showing element 3180 to 3229 of 16578 in total
Value Type  : Ranked
Filtered  : 1
Rank
description
Network Comparison Type
Interaction Map
red
network_comparison
green
795 ubiquitin-conjugating enzyme e2-32 kda complementing (ec 6.3.2.19) (ubiquitin-protein ligase) (ubiquitin carrier protein) (e2-cdc34). [swissprot;acc:p49427] Subtracted Low confidence 199.792 5.219 194.573
796 beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115] High confidence 212.386 9.399 221.785
grancalcin. [swissprot;acc:p28676] Divided Low confidence 202.524 1.02644 197.308
placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237] High confidence 224.244 1.04578 234.511
rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640] Subtracted Low confidence 202.755 5.219 197.536
797 asc-1 complex subunit p100. [refseq;acc:nm_032204] Divided 211.636 1.02644 206.184
calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632] Subtracted 202.525 5.217 197.308
cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452] Divided High confidence 224.244 1.04578 234.511
syntaxin 16 (syn16). [swissprot;acc:o14662] Subtracted 212.386 9.399 221.785
798 27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]
grancalcin. [swissprot;acc:p28676] Low confidence 202.524 5.216 197.308
leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740] Divided High confidence 224.244 1.04578 234.511
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] Low confidence 202.524 1.02644 197.308
799 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643] Subtracted 206.243 5.216 201.027
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] Divided 201.294 1.02643 196.11
sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900] High confidence 221.965 1.04501 212.404
syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623] Subtracted 212.386 9.399 221.785
800 alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]
dopachrome tautomerase precursor (ec 5.3.3.12) (dt) (dct) (dopachrome delta-isomerase) (tyrosinase-related protein 2) (trp-2) (trp2). [swissprot;acc:p40126] Low confidence 206.244 5.216 201.028
nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307] Divided High confidence 221.965 1.04501 212.404
rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640] Low confidence 202.755 1.02642 197.536
801 adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9] Subtracted High confidence 212.386 9.399 221.785
beta-catenin (pro2286). [swissprot;acc:p35222] Divided 224.445 1.04445 214.894
programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340] Low confidence 202.522 1.02641 197.311
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] Subtracted 202.524 5.216 197.308
802 dc12 protein. [refseq;acc:nm_020187] Divided 203.345 1.02639 198.117
synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721] Subtracted High confidence 212.386 9.399 221.785
testis-specific protein tex28. [swissprot;acc:o15482] Divided 1.04425
xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7] Subtracted Low confidence 201.338 5.212 196.126
803 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kda subunit precursor (ec 2.4.1.119) (ribophorin i) (rpn-i). [swissprot;acc:p04843] Divided 199.573 1.02639 194.441
olf-1/ebf associated zinc finger protein; smad- and olf-interacting zinc finger protein. [refseq;acc:nm_015069] Subtracted 204.922 5.211 199.711
similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61] Divided High confidence 212.386 1.04425 221.785
syntaxin 1b. [swissprot;acc:q15531] Subtracted 9.399
804 a kindred of iglon. [refseq;acc:nm_173808] Divided 1.04425
elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897] Low confidence 204.519 1.02636 199.267
melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084] Subtracted High confidence 212.386 9.399 221.785
programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340] Low confidence 202.522 5.211 197.311
805 ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1] Divided High confidence 212.386 1.04425 221.785
dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593] Subtracted 9.399
early hematopoietic zinc finger. [refseq;acc:nm_015461] Low confidence 204.914 5.208 199.706
synaptojanin 1 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1). [swissprot;acc:o43426] Divided 198.496 1.02635 193.399
806 inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370] High confidence 212.386 1.04425 221.785
maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708] Subtracted 267.447 9.326 276.773
mosaic protein lgn. [swissprot;acc:p81274] Low confidence 207.56 5.205 202.355
vacuolar atp synthase subunit c (ec 3.6.3.14) (v-atpase c subunit) (vacuolar proton pump c subunit). [swissprot;acc:p21283] Divided 202.369 1.02635 197.173
807 myofibrillogenesis regulator 1; trans-activated by hepatitis c virus core protein 2; likely ortholog of mouse brain protein 17. [refseq;acc:nm_022572] 200.782 1.02633 195.631
nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208] Subtracted 203.907 5.201 198.706
palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897] Divided High confidence 212.386 1.04425 221.785
trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102] Subtracted 218.521 9.275 227.796
808 60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993] 223.186 9.274 213.912

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/