Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank Filtered green Interaction Map network_comparison description Value Type red Network Comparison Type
Results: HTML CSV LaTeX Showing element 501 to 550 of 38536 in total
Network Comparison Type  : Divided
Rank
Filtered
green
Interaction Map
network_comparison
description
Value Type
red
32 0 35.5 Low confidence 2.97183 melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] Measured 105.5
184 High confidence 3.25 cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336] 598
8691.76 1.52929 importin 9. [refseq;acc:nm_018085] Ranked 13292.2
15983.3 Low confidence 1.39162 myoglobin. [swissprot;acc:p02144] 11485.4
1 43.1914 High confidence 1.65937 ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485] Rooted 26.0288
168.796 Low confidence 1.1597 mitochondrial solute carrier protein. [refseq;acc:nm_145305] 145.551
232.49 1.17505 protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690] Ranked 273.188
243.673 High confidence 1.29985 serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4] 187.462
895.893 2.04793 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] Measured 1834.73
25146.6 2.53372 beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] Squared 9924.76
43368.8 Low confidence 1.19275 nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] Measured 36360.3
61881.5 1.33073 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] Squared 82347.8
33 0 0.355148 9.62112 melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] 3.41692
4.57302 High confidence 16.8159 beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938] 76.8994
5.80678 Low confidence 1.69589 melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] Rooted 9.84765
25.7294 High confidence 2.0801 fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] 12.3693
35.5 Low confidence 2.97183 melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] Measured 105.5
39.8063 High confidence 3.15402 lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 12.6208
8691.76 1.52929 nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733] Ranked 13292.2
14746.1 Low confidence 1.37827 fk506-binding protein 6 (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (36 kda fk506 binding protein) (fkbp- 36) (immunophilin fkbp36). [swissprot;acc:o75344] 20324.1
1 43.1914 High confidence 1.65937 protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949] Rooted 26.0288
88.6244 Low confidence 1.15738 retinoblastoma-associated factor 600. [refseq;acc:nm_020765] 76.5734
242.742 High confidence 1.28647 serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154] Ranked 188.688
246.125 Low confidence 1.17068 dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985] 210.241
896.972 High confidence 2.04611 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152] Measured 1835.3
25146.6 2.53372 spermatogenesis associated 6. [refseq;acc:nm_019073] Squared 9924.76
43368.8 Low confidence 1.19275 vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682] Measured 36360.3
61881.5 1.33073 hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] Squared 82347.8
34 0 0.355148 9.62112 melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 3.41692
0.697197 High confidence 15.9968 lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 0.0435834
5.80678 Low confidence 1.69589 melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] Rooted 9.84765
11.7898 High confidence 2.02503 phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] 23.8747
35.5 Low confidence 2.97183 melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] Measured 105.5
47 High confidence 3.04255 glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] 143
7506.66 Low confidence 1.37724 fibrillin 3. [refseq;acc:nm_032447] Ranked 5450.5
17173.8 High confidence 1.52196 microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268] 11284
1 24.3678 1.65305 guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992] Rooted 40.2812
56.755 Low confidence 1.15698 putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580] 49.0544
133.876 1.16197 putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] Ranked 155.56
242.453 High confidence 1.28235 serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153] 189.07
907.546 2.02382 guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992] Measured 1836.71
6352.4 Low confidence 1.1897 protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8] 5339.5
25146.6 High confidence 2.53372 amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] Squared 9924.76
61881.5 Low confidence 1.33073 melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 82347.8
35 0 0.355148 9.62112 melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] 3.41692
5.80678 1.69589 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] Rooted 9.84765
11.7898 High confidence 2.02503 beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938] 23.8747
35.5 Low confidence 2.97183 melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] Measured 105.5
647.816 High confidence 12.7767 adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236] Squared 50.7031
1377 2.99674 Measured 459.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/