Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Rank Gene Hugo description Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1163 to 1212 of 12912 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
red
green
network_comparison
1163 ERC1 elks protein. [refseq;acc:nm_015064] 5832.13 6343.59 1.0877
1164 SLC5A5 sodium/iodide cotransporter (na(+)/i(-) cotransporter) (sodium-iodide symporter) (na+/i-symporter). [swissprot;acc:q92911] 6600.36 7178.84 1.08764
1165 PRODH2 kidney and liver proline oxidase 1. [refseq;acc:nm_021232] 6604.44 7183.07 1.08761
1166 SLC5A8 solute carrier family 5 (iodide transporter), member 8; apical iodide transporter. [refseq;acc:nm_145913] 6606.3 7185.01 1.0876
1167 SLC5A6 sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289] 6607.68 7186.45 1.08759
1168 BUB3 mitotic checkpoint protein bub3. [swissprot;acc:o43684] 5470.44 5949.49 1.08757
1169 ZNF207 zinc finger protein 207. [swissprot;acc:o43670]
1170 SUMO3 ubiquitin-like protein smt3a. [swissprot;acc:p55854] 5826.34 6335.98 1.08747
1171 no value ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855] 5826.29 6335.93
1172 ACRC acrc protein; putative nuclear protein. [refseq;acc:nm_052957] 5826.32 6335.95
1173 CABC1 chaperone-activity of bc1 complex-like, mitochondrial precursor (chaperone-abc1-like). [swissprot;acc:q8ni60] 5799.35 6305.95 1.08735
1174 TATDN1 cda11 protein. [refseq;acc:nm_032026] 5874.11 6387.23
1175 ADCK2 aarf domain containing kinase 2; putative ubiquinone biosynthesis protein aarf. [refseq;acc:nm_052853] 5799.35 6305.95
1176 ADCK4 aarf domain containing kinase 4. [refseq;acc:nm_024876]
1177 ADCK1 aarf domain containing kinase 1. [refseq;acc:nm_020421]
1178 no value pepsin a precursor (ec 3.4.23.1). [swissprot;acc:p00790] 4392.63 4776.19 1.08732
1179 SLC20A2 solute carrier family 20 (phosphate transporter), member 2; glvr-2; pit-2; gibbon ape leukemia virus receptor 2; murine leukemia virus, amphotropic; receptor. [refseq;acc:nm_006749]
1180 FDPS farnesyl pyrophosphate synthetase (fpp synthetase) (fps) (farnesyl diphosphate synthetase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10)]. [swissprot;acc:p14324]
1181 PCDH15 protocadherin 15 precursor. [swissprot;acc:q96qu1]
1182 SLC20A1 solute carrier family 20 (phosphate transporter), member 1; glvr-1; pit-1; gibbon ape leukemia virus receptor 1. [refseq;acc:nm_005415]
1183 LMBR1L lipocalin-interacting membrane receptor. [refseq;acc:nm_018113]
1184 GLI1 zinc finger protein gli1 (glioma-associated oncogene) (oncogene gli). [swissprot;acc:p08151]
1185 SUFU suppressor of fused. [refseq;acc:nm_016169]
1186 GLI3 zinc finger protein gli3. [swissprot;acc:p10071]
1187 LMBR1 limb region 1 protein; limb region 1. [refseq;acc:nm_022458]
1188 PGC gastricsin precursor (ec 3.4.23.3) (pepsinogen c). [swissprot;acc:p20142]
1189 GLI2 zinc finger protein gli2 (tax helper protein). [swissprot;acc:p10070]
1190 MAD2L1 mitotic spindle assembly checkpoint protein mad2a (mad2-like 1) (hsmad2). [swissprot;acc:q13257] 6599.84 7174.29 1.08704
1191 ATP13A2 probable cation-transporting atpase 1 (ec 3.6.1.-). [swissprot;acc:q9nq11]
1192 TBP tata box binding protein (transcription initiation factor tfiid) (tata-box factor) (tata sequence-binding protein) (tbp). [swissprot;acc:p20226]
1193 KIAA0664 putative eukaryotic translation initiation factor 3 subunit (eif-3) (fragment). [swissprot;acc:o75153] 5464.9 5940.16 1.08697
1194 CCT5 t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643] 8425.35 7751.57 1.08692
1195 PARS2 similar to trna synthetase class ii. [refseq;acc:nm_152268] 5439.56 5911.24 1.08671
1196 no value kappa b-ras 1. [refseq;acc:nm_020345] 5721.19 6217.2 1.0867
1197 NKIRAS2 i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]
1198 SNAPAP snare associated protein snapin. [refseq;acc:nm_012437]
1199 SHMT2 serine hydroxymethyltransferase, mitochondrial precursor (ec 2.1.2.1) (serine methylase) (glycine hydroxymethyltransferase) (shmt). [swissprot;acc:p34897] 5449.48 5921.77 1.08667
1200 XYLB xylulokinase homolog; xylulokinase (h. influenzae) homolog. [refseq;acc:nm_005108] 5950.27 6465.72 1.08663
1201 DTYMK thymidylate kinase (ec 2.7.4.9) (dtmp kinase). [swissprot;acc:p23919] 6042.31 6565.03 1.08651
1202 HMBS porphobilinogen deaminase (ec 4.3.1.8) (hydroxymethylbilane synthase) (hmbs) (pre-uroporphyrinogen synthase) (pbg-d). [swissprot;acc:p08397] 4913.07 5337.95 1.08648
1203 GGPS1 geranylgeranyl pyrophosphate synthetase (ggpp synthetase) (ggppsase) (geranylgeranyl diphosphate synthase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10); farnesyltranstransferase (ec 2.5.1.29)]. [swissprot;acc:o95749] 4322.65 4696.04 1.08638
1204 SOCS1 suppressor of cytokine signaling 1 (socs-1) (jak-binding protein) (jab) (stat induced stat inhibitor 1) (ssi-1) (tec-interacting protein 3) (tip-3). [swissprot;acc:o15524] 5946.33 6459.79 1.08635
1205 GMFG glia maturation factor gamma (gmf-gamma). [swissprot;acc:o60234]
1206 ASCC2 asc-1 complex subunit p100. [refseq;acc:nm_032204]
1207 FKBP1A fk506-binding protein 1a (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (12 kda fkbp) (fkbp-12) (immunophilin fkbp12). [swissprot;acc:p20071]
1208 DMC1 meiotic recombination protein dmc1/lim15 homolog. [swissprot;acc:q14565] 5913.73 6423.98 1.08628
1209 EPRS bifunctional aminoacyl-trna synthetase [includes: glutamyl-trna synthetase (ec 6.1.1.17) (glutamate--trna ligase); prolyl-trna synthetase (ec 6.1.1.15) (proline--trna ligase)]. [swissprot;acc:p07814] 5420.87 5887.53 1.08609
1210 TMLHE trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6] 6410.73 6962.22 1.08603
1211 ERAL1 gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]
1212 KRR1 hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043] 4077.89 4428.28 1.08592

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/