Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Value Type Rank network_comparison green description Filtered Network Comparison Type Interaction Map red
Results: HTML CSV LaTeX Showing element 551 to 600 of 19268 in total
Value Type  : Measured
Rank
network_comparison
green
description
Filtered
Network Comparison Type
Interaction Map
red
69 1023.94 3007.85 trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477] 1 Subtracted Low confidence 1983.91
3742.9 13995.6 cyclin g1 (cyclin g). [swissprot;acc:p51959] High confidence 17738.5
70 1.12253 7848.45 y+l amino acid transporter 1 (y(+)l-type amino acid transporter 1) (y+lat-1) (y+lat1) (monocyte amino acid permease 2) (mop-2). [swissprot;acc:q9um01] Divided Low confidence 6991.78
1.59177 10307.5 amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] High confidence 6475.5
1.75947 1068 importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [swissprot;acc:p52292] 0 607
1.82368 305.886 synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] Low confidence 167.73
383.13 1971.17 zinc finger imprinted 3. [swissprot;acc:q96pe6] Subtracted 2354.3
431 139 beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938] High confidence 570
1016.8 11515.8 septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6] 1 Low confidence 10499
3742.8 13995.7 serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537] High confidence 17738.5
71 1.12253 7848.45 cystine/glutamate transporter (amino acid transport system xc-) (xct) (calcium channel blocker resistance protein ccbr1). [swissprot;acc:q9upy5] Divided Low confidence 6991.78
1.54716 2945.26 serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007] High confidence 4556.78
1.75762 352.75 ubiquitin protein ligase. [refseq;acc:nm_130466] 0 620
1.80287 150.001 zona pellucida sperm-binding protein 3 precursor (zona pellucida glycoprotein zp3) (zona pellucida protein c) (sperm receptor) (zp3a/zp3b). [swissprot;acc:p21754] Low confidence 270.432
383.11 1970.95 zinc finger protein 233. [refseq;acc:nm_181756] Subtracted 2354.06
430.7 4228.27 tubby protein homolog. [swissprot;acc:p50607] High confidence 3797.57
1012.9 6352.4 protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8] 1 Low confidence 5339.5
3742.8 13995.7 serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172] High confidence 17738.5
72 1.12253 7848.45 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6. [refseq;acc:nm_003983] Divided Low confidence 6991.78
1.54715 2945.28 uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48] High confidence 4556.79
1.73441 992.083 60s ribosomal protein l21. [swissprot;acc:p46778] 0 572
1.79562 150.995 b24o18.3 (pom121 membrane glycoprotein (rat homolog)-like 2). [sptrembl;acc:q96kw2] Low confidence 271.129
383.11 1970.91 zinc finger protein 334. [swissprot;acc:q9hcz1] Subtracted 2354.02
427.431 1106.88 rab gdp dissociation inhibitor alpha (rab gdi alpha) (gdi-1) (xap-4) (oligophrenin 2). [swissprot;acc:p31150] High confidence 679.449
1001.53 10633 serine/threonine-protein kinase mak (ec 2.7.1.-) (male germ cell- associated kinase). [swissprot;acc:p20794] 1 Low confidence 9631.47
3733.2 13977.7 b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056] High confidence 17710.9
73 1.12253 7848.45 eukaryotic translation initiation factor 4b (eif-4b). [swissprot;acc:p23588] Divided Low confidence 6991.78
1.54711 2945.38 serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005] High confidence 4556.83
1.73233 37.693 protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 0 65.2968
1.78524 385.626 soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825] Low confidence 688.436
383.1 1970.8 krab zinc finger protein hzf26 (fragment). [sptrembl;acc:q9bze6] Subtracted 2353.9
424.22 2389.69 sal-like protein 4 (zinc finger protein sall4). [swissprot;acc:q9ujq4] High confidence 1965.47
997.75 10621.3 intestinal cell kinase isoform a; mak-related kinase; serine/threonine protein kinase. [refseq;acc:nm_014920] 1 Low confidence 9623.55
3708.4 18560.4 serine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g). [swissprot;acc:p36873] High confidence 22268.8
74 1.12253 7848.45 b(0,+)-type amino acid transporter 1 (b(0,+)at) (glycoprotein- associated amino acid transporter b0,+at1). [swissprot;acc:p82251] Divided Low confidence 6991.78
1.54694 2945.8 serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4] High confidence 4556.99
1.71473 859.34 bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820] 0 501.151
1.78378 37 arf gtpase-activating protein. [refseq;acc:nm_133446] Low confidence 66
383.1 1970.76 zinc finger protein 195. [swissprot;acc:o14628] Subtracted 2353.86
421.3 14688.8 glycogenin-2 (ec 2.4.1.186) (gn-2) (gn2). [swissprot;acc:o15488] High confidence 14267.5
966.8 10318.5 melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 1 Low confidence 11285.3
3690.3 24136.4 homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017] High confidence 20446.1
75 1.11418 12942.3 septin 7 (cdc10 protein homolog). [swissprot;acc:q16181] Divided Low confidence 11616
1.5137 2907.43 nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181] High confidence 1920.75
1.71412 925.298 oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977] 0 1586.07
1.78378 37 up-regulated in liver cancer 1; similar to development- and differentiation-enhancing factor 2. [refseq;acc:nm_017707] Low confidence 66
383.09 1970.7 zinc finger protein 230 (zinc finger protein fdzf2). [swissprot;acc:q9uie0] Subtracted 2353.79
420.083 992.083 60s ribosomal protein l21. [swissprot;acc:p46778] High confidence 572
966.8 10318.5 hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703] 1 Low confidence 11285.3
3690.3 24136.4 homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483] High confidence 20446.1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/