Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank description Gene Network Comparison Type Value Type Hugo Interaction Map red Filtered green network_comparison
Results: HTML CSV LaTeX Showing element 2130 to 2179 of 16578 in total
Value Type  : Ranked
Filtered  : 1
Rank
description
Network Comparison Type
Hugo
Interaction Map
red
green
network_comparison
533 membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9] Divided SLC45A2 High confidence 250.942 235.004 1.06782
selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903] Subtracted SEPHS1 Low confidence 206.406 200.027 6.379
solute carrier family 2, facilitated glucose transporter, member 1 (glucose transporter type 1, erythrocyte/brain) (hepg2 glucose transporter). [swissprot;acc:p11166] Divided SLC2A1 205.533 199.112 1.03225
534 guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915] no value High confidence 250.942 235.004 1.06782
inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566] Subtracted INPP4A Low confidence 206.406 200.027 6.379
pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] PANK1 High confidence 58 44 14
zinc finger protein 216. [swissprot;acc:o76080] Divided ZFAND5 Low confidence 184.361 178.613 1.03218
535 dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434] POLR2H High confidence 236.662 252.708 1.0678
hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500] Subtracted HTATSF1 Low confidence 209.347 202.978 6.369
myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623] MYH4 High confidence 112 126 14
protein associated with prk1. [refseq;acc:nm_019006] Divided ZFAND6 Low confidence 184.361 178.613 1.03218
536 lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455] SSB High confidence 242.531 227.136 1.06778
myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535] Subtracted MYH8 112 126 14
ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493] Divided RANBP9 Low confidence 203.519 197.195 1.03207
ring finger protein 7; sensitive to apoptosis gene. [refseq;acc:nm_014245] Subtracted RNF7 203.162 196.796 6.366
537 megf11 protein. [refseq;acc:nm_032445] Divided MEGF11 207.951 201.517 1.03193
potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110] Subtracted ATP9A 202.845 209.189 6.344
putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] UBAC1 High confidence 10 24 14
putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143] Divided DHX15 229.803 215.301 1.06736
538 dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436] POLR2L 237.627 253.604 1.06724
megf10 protein. [refseq;acc:nm_032446] MEGF10 Low confidence 207.949 201.517 1.03192
pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23] Subtracted PANK2 High confidence 58 44 14
ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493] RANBP9 Low confidence 203.519 197.195 6.324
539 myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2] MYH2 High confidence 112 126 14
preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387] MOBKL3 Low confidence 206.737 200.417 6.32
protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316] Divided MEMO1P High confidence 236.964 252.86 1.06708
protein x 0001. [refseq;acc:nm_016302] CRBN Low confidence 199.661 193.489 1.0319
540 dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4] Subtracted DNAJB11 206.737 200.417 6.32
pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999] PANK3 High confidence 58 44 14
selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611] Divided SEPHS2 222.156 208.201 1.06703
Low confidence 206.406 200.027 1.03189
541 adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5] Subtracted AP1M2 205.768 199.453 6.315
flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632] Divided MICAL2 High confidence 222.156 208.201 1.06703
Low confidence 206.406 200.027 1.03189
myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055] Subtracted MYH3 High confidence 112 126 14
542 inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866] Divided INPP4B 222.156 208.201 1.06703
Low confidence 206.406 200.027 1.03189
myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882] Subtracted MYH1 High confidence 112 126 14
squamous cell carcinoma antigen recognized by t cells 1; u4/u6.u5 tri-snrnp-associated 110 kda protein; ige autoantigen; sart1(259) protein; sart1(800) protein. [refseq;acc:nm_005146] SART1 Low confidence 200.271 193.957 6.314
543 adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5] AP1M1 205.75 199.452 6.298
myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883] no value High confidence 112 126 14
selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903] Divided SEPHS1 222.156 208.201 1.06703
Low confidence 206.406 200.027 1.03189
544 dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430] Subtracted MYH7B High confidence 112 126 14
inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566] Divided INPP4A 222.156 208.201 1.06703
Low confidence 206.406 200.027 1.03189
nuclear transport factor 2 (ntf-2) (placental protein 15) (pp15). [swissprot;acc:p13662] Subtracted NUTF2 205.57 199.279 6.291
545 c18b11 homolog (44.9kd). [refseq;acc:nm_152260] Divided RPUSD2 202.949 196.678 1.03188
eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537] EIF6 High confidence 248.866 233.287 1.06678
mitochondrial solute carrier protein. [refseq;acc:nm_145305] Subtracted SLC25A43 58 44 14

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/